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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-08-2020 | Research Article

Performing IVIM-DWI using the multifunctional nanosystem for the evaluation of the antitumor microcirculation changes

Authors: Peng Gao, Yiyong Liu, Changzheng Shi, Yubao Liu, Liangping Luo

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 4/2020

Abstract

Objectives

There is a controversy about the D* and f values of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for mid- and long-term efficacy monitoring of tumor blood perfusion. To monitor the antitumor efficacy of the F/A-PLGA@DOX/SPIO nanosystem via IVIM-DWI and to explore the value of parameters pseudo-diffusion (D*) and fraction of pseudo-diffusion (f) for evaluating therapeutic effect in non-small cell lung cancer (NSCLC).

Materials and methods

Thirty-six A549 tumor-bearing mice were divided randomly into three groups (each n = 12). Group 1 (G1) was injected with saline (the control group). Group 2 (G2) and group 3(G3) were injected with DOX and F/A-PLGA@DOX/SPIO, respectively. Each group underwent IVIM-DWI scanning at baseline and 3, 14, 21, and 28 days after treatment. D* and f values were derived using GE AW 4.5 post-processing station. All mice were sacrificed for pathological examination.

Results

The D* value of all three groups showed an upward trend, with the highest increase in G1 and the lowest in G3. Conversely, the f value of all groups trended to decrease within 7 days, of which G3 showed the most significant decline. Immunohistochemical staining revealed that vascular endothelial growth factor (VEGF)-positive staining rate and the microvessel density (MVD) of the tumors in G3 were significantly lower than those of the other groups (P < 0.05). The D* and f values were significantly and positively correlated to CD31 (r = 0.654, P < 0.001; r = 0.712, P < 0.001) and VEGF (r = 0.694, P < 0.001; r = 0.664, P < 0.001).

Conclusion

IVIM-DWI-derived parameters D* and f are valuable indicators for the evaluation of the antitumor microcirculation changes of multifunctional nanosystem.

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Title: Performing IVIM-DWI using the multifunctional nanosystem for the evaluation of the antitumor microcirculation changes
Authors: Peng Gao
Yiyong Liu
Changzheng Shi
Yubao Liu
Liangping Luo
Publication date: 01-08-2020
Publisher: Springer International Publishing
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 4/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00814-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Performing IVIM-DWI using the multifunctional nanosystem for the evaluation of the antitumor microcirculation changes

Abstract

Objectives

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusion

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