Skip to main content
Top
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 1/2020

Open Access 01-02-2020 | Magnetic Resonance Imaging | Research Article

Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA

Authors: Iosif Mendichovszky, Pim Pullens, Ilona Dekkers, Fabio Nery, Octavia Bane, Andreas Pohlmann, Anneloes de Boer, Alexandra Ljimani, Aghogho Odudu, Charlotte Buchanan, Kanishka Sharma, Christoffer Laustsen, Anita Harteveld, Xavier Golay, Ivan Pedrosa, David Alsop, Sean Fain, Anna Caroli, Pottumarthi Prasad, Susan Francis, Eric Sigmund, Maria Fernández‐Seara, Steven Sourbron

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2020

Login to get access

Abstract

Purpose

The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on renal MRI.

Methods

A task force was formed in July 2018 focused on five methods. A draft process for attaining consensus was distributed publicly for consultation and finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between October 2018 and March 2019, discussed results and refined the surveys at a face-to-face meeting (Aarhus, March 2019) and completed a second round (May 2019).

Results

A seven-stage process was defined: (1) formation of expert panels; (2) definition of the context of use; (3) literature review; (4) collection and comparison of MRI protocols; (5) consensus generation by an approximate Delphi method; (6) reporting of results in vendor-neutral and vendor-specific terms; (7) ongoing review and updating. Application of the process resulted in 166 consensus statements.

Conclusion

The process generated meaningful technical recommendations across very different MRI methods, while allowing for improvement and refinement as open issues are resolved. The results are likely to be widely supported by the renal MRI community and thereby promote more harmonisation.
Literature
8.
go back to reference Caroli A, Pruijm M, Burnier M, Selby NM (2018) Functional magnetic resonance imaging of the kidneys: where do we stand? The perspective of the European COST Action PARENCHIMA. Nephrol Dial Transplant. 33:ii1PubMedPubMedCentralCrossRef Caroli A, Pruijm M, Burnier M, Selby NM (2018) Functional magnetic resonance imaging of the kidneys: where do we stand? The perspective of the European COST Action PARENCHIMA. Nephrol Dial Transplant. 33:ii1PubMedPubMedCentralCrossRef
9.
go back to reference Selby NM et al (2018) Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrol Dial Transplant 33:ii4–ii14PubMedPubMedCentralCrossRef Selby NM et al (2018) Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrol Dial Transplant 33:ii4–ii14PubMedPubMedCentralCrossRef
11.
go back to reference Pruijm M et al (2018) Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review. Nephrol Dial Transplant 33:ii22–ii28PubMedPubMedCentralCrossRef Pruijm M et al (2018) Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review. Nephrol Dial Transplant 33:ii22–ii28PubMedPubMedCentralCrossRef
12.
go back to reference Jerome NP et al (2018) Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper. Nephrol Dial Transplant 33:ii41–ii50PubMedPubMedCentralCrossRef Jerome NP et al (2018) Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper. Nephrol Dial Transplant 33:ii41–ii50PubMedPubMedCentralCrossRef
13.
go back to reference Odudu A et al (2018) Arterial spin labelling MRI to measure renal perfusion: a systematic review and statement paper. Nephrol Dial Transplant 33:ii15–ii21PubMedPubMedCentralCrossRef Odudu A et al (2018) Arterial spin labelling MRI to measure renal perfusion: a systematic review and statement paper. Nephrol Dial Transplant 33:ii15–ii21PubMedPubMedCentralCrossRef
14.
go back to reference Caroli A et al (2018) Diffusion-weighted magnetic resonance imaging to assess diffuse renal pathology: a systematic review and statement paper. Nephrol Dial Transplant 33:29–40CrossRef Caroli A et al (2018) Diffusion-weighted magnetic resonance imaging to assess diffuse renal pathology: a systematic review and statement paper. Nephrol Dial Transplant 33:29–40CrossRef
16.
go back to reference Alsop DC et al (2015) Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73:102–116PubMedCrossRef Alsop DC et al (2015) Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73:102–116PubMedCrossRef
17.
go back to reference Dalkey N, Helmer O (1963) An experimental application of the DELPHI method to the use of experts. Manage Sci 9:458–467CrossRef Dalkey N, Helmer O (1963) An experimental application of the DELPHI method to the use of experts. Manage Sci 9:458–467CrossRef
20.
go back to reference Muller BG et al (2014) Role of multiparametric magnetic resonance imaging (MRI) in focal therapy for prostate cancer: a Delphi consensus project. BJU Int 114:698–707PubMedCrossRef Muller BG et al (2014) Role of multiparametric magnetic resonance imaging (MRI) in focal therapy for prostate cancer: a Delphi consensus project. BJU Int 114:698–707PubMedCrossRef
21.
go back to reference Taylor SA et al (2017) The first joint ESGAR/ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging. Eur Radiol 27:2570–2582PubMedCrossRef Taylor SA et al (2017) The first joint ESGAR/ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging. Eur Radiol 27:2570–2582PubMedCrossRef
22.
go back to reference Meshkat B et al (2014) Using an e-Delphi technique in achieving consensus across disciplines for developing best practice in day surgery in Ireland. J Hosp Adm 3:1–8 Meshkat B et al (2014) Using an e-Delphi technique in achieving consensus across disciplines for developing best practice in day surgery in Ireland. J Hosp Adm 3:1–8
23.
go back to reference Litière S, Collette S, De Vries EGE, Seymour L, Bogaerts J (2017) RECIST–learning from the past to build the future. Nat Rev Clin Oncol 14:187PubMedCrossRef Litière S, Collette S, De Vries EGE, Seymour L, Bogaerts J (2017) RECIST–learning from the past to build the future. Nat Rev Clin Oncol 14:187PubMedCrossRef
25.
go back to reference Warach SJ et al (2016) Acute stroke imaging research roadmap III imaging selection and outcomes in acute stroke reperfusion clinical trials: consensus recommendations and further research priorities. Stroke 47:1389–1398PubMedPubMedCentralCrossRef Warach SJ et al (2016) Acute stroke imaging research roadmap III imaging selection and outcomes in acute stroke reperfusion clinical trials: consensus recommendations and further research priorities. Stroke 47:1389–1398PubMedPubMedCentralCrossRef
28.
go back to reference Sourbron SP, Michaely HJ, Reiser MF, Schoenberg SO (2008) MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model. Invest Radiol 43(1):40–48PubMedCrossRef Sourbron SP, Michaely HJ, Reiser MF, Schoenberg SO (2008) MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model. Invest Radiol 43(1):40–48PubMedCrossRef
29.
go back to reference Zhang JL et al (2014) New magnetic resonance imaging methods in nephrology. Kidney Int 85:768–778PubMedCrossRef Zhang JL et al (2014) New magnetic resonance imaging methods in nephrology. Kidney Int 85:768–778PubMedCrossRef
30.
go back to reference Bokacheva L, Rusinek H, Zhang JL, Lee VS (2008) Assessment of renal function with dynamic contrast-enhanced MR imaging. Magn Reson Imag Clin N Am. 16:597–611CrossRef Bokacheva L, Rusinek H, Zhang JL, Lee VS (2008) Assessment of renal function with dynamic contrast-enhanced MR imaging. Magn Reson Imag Clin N Am. 16:597–611CrossRef
31.
go back to reference Bokacheva L, Rusinek H, Zhang JL, Chen Q, Lee VS (2009) Estimates of glomerular filtration rate from MR renography and tracer kinetic models. J Magn Reson Imaging 29:371–382PubMedPubMedCentralCrossRef Bokacheva L, Rusinek H, Zhang JL, Chen Q, Lee VS (2009) Estimates of glomerular filtration rate from MR renography and tracer kinetic models. J Magn Reson Imaging 29:371–382PubMedPubMedCentralCrossRef
32.
go back to reference Vivier P-H et al (2011) Kidney function: glomerular filtration rate measurement with MR renography in patients with cirrhosis. Radiology 259:462–470PubMedCrossRef Vivier P-H et al (2011) Kidney function: glomerular filtration rate measurement with MR renography in patients with cirrhosis. Radiology 259:462–470PubMedCrossRef
33.
go back to reference Lim SW, Chrysochou C, Buckley DL, Kalra PA, Sourbron SP (2013) Prediction and assessment of responses to renal artery revascularization with dynamic contrast-enhanced magnetic resonance imaging: a pilot study. Am J Physiol Renal Physiol 305(5):672–678CrossRef Lim SW, Chrysochou C, Buckley DL, Kalra PA, Sourbron SP (2013) Prediction and assessment of responses to renal artery revascularization with dynamic contrast-enhanced magnetic resonance imaging: a pilot study. Am J Physiol Renal Physiol 305(5):672–678CrossRef
34.
go back to reference Basak S et al (2019) Analytical validation of single-kidney glomerular filtration rate and split renal function as measured with magnetic resonance renography. Magn Reson Imaging 59:53–60PubMedCrossRef Basak S et al (2019) Analytical validation of single-kidney glomerular filtration rate and split renal function as measured with magnetic resonance renography. Magn Reson Imaging 59:53–60PubMedCrossRef
35.
go back to reference Prowle JR, Molan MP, Hornsey E, Bellomo R (2012) Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Crit Care Med 40:1768–1776PubMedCrossRef Prowle JR, Molan MP, Hornsey E, Bellomo R (2012) Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Crit Care Med 40:1768–1776PubMedCrossRef
36.
go back to reference Debatin JF et al (2014) Renal artery blood flow: quantitation with phase-contrast MR imaging with and without breath holding. Radiology 190:371–378CrossRef Debatin JF et al (2014) Renal artery blood flow: quantitation with phase-contrast MR imaging with and without breath holding. Radiology 190:371–378CrossRef
37.
go back to reference Schoenberg SO et al (2014) Renal artery stenosis: grading of hemodynamic changes with cine phase-contrast MR blood flow measurements. Radiology 203:45–53CrossRef Schoenberg SO et al (2014) Renal artery stenosis: grading of hemodynamic changes with cine phase-contrast MR blood flow measurements. Radiology 203:45–53CrossRef
38.
go back to reference Khatir DS, Pedersen M, Jespersen B, Buus NH (2015) Evaluation of renal blood flow and oxygenation in CKD using magnetic resonance imaging. Am J Kidney Dis 66:402–411PubMedCrossRef Khatir DS, Pedersen M, Jespersen B, Buus NH (2015) Evaluation of renal blood flow and oxygenation in CKD using magnetic resonance imaging. Am J Kidney Dis 66:402–411PubMedCrossRef
39.
go back to reference Will S, Martirosian P, Würslin C, Schick F (2014) Automated segmentation and volumetric analysis of renal cortex, medulla, and pelvis based on non-contrast-enhanced T1- and T2-weighted MR images. Magn Reson Mater Phy 27:445–454CrossRef Will S, Martirosian P, Würslin C, Schick F (2014) Automated segmentation and volumetric analysis of renal cortex, medulla, and pelvis based on non-contrast-enhanced T1- and T2-weighted MR images. Magn Reson Mater Phy 27:445–454CrossRef
40.
go back to reference Rusinek H et al (2016) A semi-automated ‘blanket’ method for renal segmentation from non-contrast T1-weighted MR images. Magn Reson Mater Phys Biol Med 29:197–206CrossRef Rusinek H et al (2016) A semi-automated ‘blanket’ method for renal segmentation from non-contrast T1-weighted MR images. Magn Reson Mater Phys Biol Med 29:197–206CrossRef
41.
go back to reference Seuss H et al (2017) Development and evaluation of a semi-automated segmentation tool and a modified ellipsoid formula for volumetric analysis of the kidney in non-contrast T2-weighted MR images. J Digit Imaging 30:244–254PubMedCrossRef Seuss H et al (2017) Development and evaluation of a semi-automated segmentation tool and a modified ellipsoid formula for volumetric analysis of the kidney in non-contrast T2-weighted MR images. J Digit Imaging 30:244–254PubMedCrossRef
42.
go back to reference Christensen RH, Lundgren T, Stenvinkel P, Brismar TB (2017) Renal volumetry with magnetic resonance imaging. Acta Radiol Open 6:2058460117731120PubMedPubMedCentral Christensen RH, Lundgren T, Stenvinkel P, Brismar TB (2017) Renal volumetry with magnetic resonance imaging. Acta Radiol Open 6:2058460117731120PubMedPubMedCentral
43.
go back to reference Jiang K et al (2017) Noninvasive assessment of renal fibrosis with magnetization transfer MR imaging: validation and evaluation in murine renal artery stenosis. Radiology 283:77–86PubMedCrossRef Jiang K et al (2017) Noninvasive assessment of renal fibrosis with magnetization transfer MR imaging: validation and evaluation in murine renal artery stenosis. Radiology 283:77–86PubMedCrossRef
44.
go back to reference Wang H et al (2005) Validation of an accelerated ‘demons’ algorithm for deformable image registration in radiation therapy. Phys Med Biol 50(12):2887–2905PubMedCrossRef Wang H et al (2005) Validation of an accelerated ‘demons’ algorithm for deformable image registration in radiation therapy. Phys Med Biol 50(12):2887–2905PubMedCrossRef
45.
go back to reference Warner L et al (2011) Noninvasive in vivo assessment of renal tissue elasticity during graded renal ischemia using MR elastography. Invest Radiol 46:509PubMedPubMedCentralCrossRef Warner L et al (2011) Noninvasive in vivo assessment of renal tissue elasticity during graded renal ischemia using MR elastography. Invest Radiol 46:509PubMedPubMedCentralCrossRef
46.
go back to reference Rouvière O, Souchon R, Pagnoux G, Ménager JM, Chapelon JY (2011) Magnetic resonance elastography of the kidneys: feasibility and reproducibility in young healthy adults. J Magn Reson Imaging 34:880–886PubMedPubMedCentralCrossRef Rouvière O, Souchon R, Pagnoux G, Ménager JM, Chapelon JY (2011) Magnetic resonance elastography of the kidneys: feasibility and reproducibility in young healthy adults. J Magn Reson Imaging 34:880–886PubMedPubMedCentralCrossRef
48.
go back to reference Marticorena Garcia SR et al (2018) Tomoelastography of the native kidney: regional variation and physiological effects on in vivo renal stiffness. Magn. Reson. Med. 79:2126–2134PubMedCrossRef Marticorena Garcia SR et al (2018) Tomoelastography of the native kidney: regional variation and physiological effects on in vivo renal stiffness. Magn. Reson. Med. 79:2126–2134PubMedCrossRef
49.
go back to reference Jonker JT et al (2018) Metabolic imaging of fatty kidney in diabesity: validation and dietary intervention. Nephrol Dial Transplant 33:224–230PubMedCrossRef Jonker JT et al (2018) Metabolic imaging of fatty kidney in diabesity: validation and dietary intervention. Nephrol Dial Transplant 33:224–230PubMedCrossRef
50.
go back to reference Dekkers IA, de Heer P, Bizino MB, de Vries APJ, Lamb HJ (2018) 1H-MRS for the assessment of renal triglyceride content in humans at 3T: a primer and reproducibility study. J Magn Reson Imaging 48:507–513PubMedCrossRef Dekkers IA, de Heer P, Bizino MB, de Vries APJ, Lamb HJ (2018) 1H-MRS for the assessment of renal triglyceride content in humans at 3T: a primer and reproducibility study. J Magn Reson Imaging 48:507–513PubMedCrossRef
51.
go back to reference Brooks SA et al (2016) Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression. Clin Cancer Res 22:2950–2959PubMedPubMedCentralCrossRef Brooks SA et al (2016) Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression. Clin Cancer Res 22:2950–2959PubMedPubMedCentralCrossRef
52.
go back to reference Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S (2017) Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI. NMR Biomed. 30:e3720CrossRef Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S (2017) Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI. NMR Biomed. 30:e3720CrossRef
53.
go back to reference Li X, Auerbach EJ, Van de Moortele PF, Ugurbil K, Metzger GJ (2018) Quantitative single breath-hold renal arterial spin labeling imaging at 7T. Magn Reson Med 79:815–825PubMedCrossRef Li X, Auerbach EJ, Van de Moortele PF, Ugurbil K, Metzger GJ (2018) Quantitative single breath-hold renal arterial spin labeling imaging at 7T. Magn Reson Med 79:815–825PubMedCrossRef
54.
go back to reference Budjan J et al (2016) Renal denervation in patients with resistant hypertension-assessment by 3T renal 23Na-MRI: preliminary results. Vivo (Brooklyn) 30:657–662 Budjan J et al (2016) Renal denervation in patients with resistant hypertension-assessment by 3T renal 23Na-MRI: preliminary results. Vivo (Brooklyn) 30:657–662
57.
go back to reference Gorgolewski KJ et al (2016) The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments. Sci Data 3:160044PubMedPubMedCentralCrossRef Gorgolewski KJ et al (2016) The brain imaging data structure, a format for organizing and describing outputs of neuroimaging experiments. Sci Data 3:160044PubMedPubMedCentralCrossRef
Metadata
Title
Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA
Authors
Iosif Mendichovszky
Pim Pullens
Ilona Dekkers
Fabio Nery
Octavia Bane
Andreas Pohlmann
Anneloes de Boer
Alexandra Ljimani
Aghogho Odudu
Charlotte Buchanan
Kanishka Sharma
Christoffer Laustsen
Anita Harteveld
Xavier Golay
Ivan Pedrosa
David Alsop
Sean Fain
Anna Caroli
Pottumarthi Prasad
Susan Francis
Eric Sigmund
Maria Fernández‐Seara
Steven Sourbron
Publication date
01-02-2020
Publisher
Springer International Publishing
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-019-00784-w

Other articles of this Issue 1/2020

Magnetic Resonance Materials in Physics, Biology and Medicine 1/2020 Go to the issue