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Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 1/2020

01-02-2020 | Magnetic Resonance Imaging | Review

Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality

Authors: Michael Pedersen, Stephan Ursprung, Jens Dam Jensen, Bente Jespersen, Ferdia Gallagher, Christoffer Laustsen

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2020

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Abstract

Magnetic resonance imaging (MRI) is a well-established modality for assessing renal morphology and function, as well as changes that occur during disease. However, the significant metabolic changes associated with renal disease are more challenging to assess with MRI. Hyperpolarized carbon-13 MRI is an emerging technique which provides an opportunity to probe metabolic alterations at high sensitivity by providing an increase in the signal-to-noise ratio of 20,000-fold or more. This review will highlight the current status of hyperpolarised 13C-MRI and its translation into the clinic and how it compares to metabolic measurements provided by competing technologies such as positron emission tomography (PET).
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Metadata
Title
Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality
Authors
Michael Pedersen
Stephan Ursprung
Jens Dam Jensen
Bente Jespersen
Ferdia Gallagher
Christoffer Laustsen
Publication date
01-02-2020
Publisher
Springer International Publishing
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-019-00801-y

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