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Published in: The Journal of Headache and Pain 2/2011

Open Access 01-04-2011 | Original Article

Self-medication of migraine and tension-type headache: summary of the evidence-based recommendations of the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG), the Deutsche Gesellschaft für Neurologie (DGN), the Österreichische Kopfschmerzgesellschaft (ÖKSG) and the Schweizerische Kopfwehgesellschaft (SKG)

Authors: Gunther Haag, Hans-Christoph Diener, Arne May, Christian Meyer, Hartmut Morck, Andreas Straube, Peter Wessely, Stefan Evers

Published in: The Journal of Headache and Pain | Issue 2/2011

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Abstract

The current evidence-based guideline on self-medication in migraine and tension-type headache of the German, Austrian and Swiss headache societies and the German Society of Neurology is addressed to physicians engaged in primary care as well as pharmacists and patients. The guideline is especially concerned with the description of the methodology used, the selection process of the literature used and which evidence the recommendations are based upon. The following recommendations about self-medication in migraine attacks can be made: The efficacy of the fixed-dose combination of acetaminophen, acetylsalicylic acid and caffeine and the monotherapies with ibuprofen or naratriptan or acetaminophen or phenazone are scientifically proven and recommended as first-line therapy. None of the substances used in self-medication in migraine prophylaxis can be seen as effective. Concerning the self-medication in tension-type headache, the following therapies can be recommended as first-line therapy: the fixed-dose combination of acetaminophen, acetylsalicylic acid and caffeine as well as the fixed combination of acetaminophen and caffeine as well as the monotherapies with ibuprofen or acetylsalicylic acid or diclofenac. The four scientific societies hope that this guideline will help to improve the treatment of headaches which largely is initiated by the patients themselves without any consultation with their physicians.
Literature
1.
go back to reference Haag G, Evers S, May A, Neu IS, Vivell W, Ziegler A (2004) Selbstmedikation bei Migräne und Kopfschmerz vom Spannungstyp. Evidenzbasierte Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft (DMKG) [Self medication in migraine and tension-type headache—evidence-based treatment recommendations of the German Migraine and Headache Society]. Nervenheilkunde 23:415–430 Haag G, Evers S, May A, Neu IS, Vivell W, Ziegler A (2004) Selbstmedikation bei Migräne und Kopfschmerz vom Spannungstyp. Evidenzbasierte Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft (DMKG) [Self medication in migraine and tension-type headache—evidence-based treatment recommendations of the German Migraine and Headache Society]. Nervenheilkunde 23:415–430
2.
go back to reference Headache Classification Subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd edition (ICHD-II). Cephalalgia 24:S9–S160CrossRef Headache Classification Subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd edition (ICHD-II). Cephalalgia 24:S9–S160CrossRef
5.
go back to reference Grimshaw J, Eccles M, Russell I (1995) Developing clinically valid practice guidelines. J Eval Clin Pract 1:37–48, 9238556, 1:STN:280:DyaK2szotFahtg%3D%3DPubMedCrossRef Grimshaw J, Eccles M, Russell I (1995) Developing clinically valid practice guidelines. J Eval Clin Pract 1:37–48, 9238556, 1:STN:280:DyaK2szotFahtg%3D%3DPubMedCrossRef
7.
go back to reference Sackett DL, Straus SE, Richardson WS, Rosenberg W, Haynes RB (2000) Evidence-based medicine—how to practice and teach EBM. Churchill Livingstone, Edinburgh Sackett DL, Straus SE, Richardson WS, Rosenberg W, Haynes RB (2000) Evidence-based medicine—how to practice and teach EBM. Churchill Livingstone, Edinburgh
9.
go back to reference McDonald S, Antes G, Galandi D, Gøtzsche P, Hammarquist C, Haugh M, Jensen KL, Kleijnen J, Loep M, Pistotti V, Rüther A (2002) The contribution of handsearching European general health care journals to the Cochrane Controlled Trials Register. Eval Health Prof 25:65–75, 11868446PubMedCrossRef McDonald S, Antes G, Galandi D, Gøtzsche P, Hammarquist C, Haugh M, Jensen KL, Kleijnen J, Loep M, Pistotti V, Rüther A (2002) The contribution of handsearching European general health care journals to the Cochrane Controlled Trials Register. Eval Health Prof 25:65–75, 11868446PubMedCrossRef
10.
go back to reference Bickley SR, Harrison JE (2003) How to … find the evidence. J Orthodontics 30:72–78, 1:STN:280:DC%2BD3s7jtVansQ%3D%3DCrossRef Bickley SR, Harrison JE (2003) How to … find the evidence. J Orthodontics 30:72–78, 1:STN:280:DC%2BD3s7jtVansQ%3D%3DCrossRef
11.
go back to reference Shekelle PG, Morton SC, Suttorp MJ, Buscemi N, Friesen C (2005) Challenges in systematic reviews of complementary and alternative medicine topics. Ann Intern Med 142:1042–1047, 15968028PubMedCrossRef Shekelle PG, Morton SC, Suttorp MJ, Buscemi N, Friesen C (2005) Challenges in systematic reviews of complementary and alternative medicine topics. Ann Intern Med 142:1042–1047, 15968028PubMedCrossRef
12.
go back to reference Berger VW, Christophi CA (2003) Randomization technique, allocation concealment, masking, and susceptibility of trials to selection bias. J Mod Appl Stat Methods 2:80–86 Berger VW, Christophi CA (2003) Randomization technique, allocation concealment, masking, and susceptibility of trials to selection bias. J Mod Appl Stat Methods 2:80–86
13.
go back to reference European Agency for the Evaluation of Medicinal Products (EMEA) (1998) ICH Topic E 9 Statistical Principles for Clinical Trials. Step 5. Note for guidance on statistical principles for clinical trials. CPMP/ICH/363/96, Sep 1998 European Agency for the Evaluation of Medicinal Products (EMEA) (1998) ICH Topic E 9 Statistical Principles for Clinical Trials. Step 5. Note for guidance on statistical principles for clinical trials. CPMP/ICH/363/96, Sep 1998
14.
go back to reference Juhl RP (1998) Prescription to over-the-counter switch: a regulatory perspective. Clin Therap 20(Suppl C):C111–C117 Juhl RP (1998) Prescription to over-the-counter switch: a regulatory perspective. Clin Therap 20(Suppl C):C111–C117
15.
go back to reference Berger VW, Weinstein S (2004) Ensuring the comparability of comparison groups: is randomization enough? Control Clin Trials 25:515–524, 15465620PubMedCrossRef Berger VW, Weinstein S (2004) Ensuring the comparability of comparison groups: is randomization enough? Control Clin Trials 25:515–524, 15465620PubMedCrossRef
17.
go back to reference Hamunen K, Kalso E (2005) A systematic review of trial methodology, using the placebo groups of randomized controlled trials in paediatric postoperative pain. Pain 116:146–158, 15936888PubMedCrossRef Hamunen K, Kalso E (2005) A systematic review of trial methodology, using the placebo groups of randomized controlled trials in paediatric postoperative pain. Pain 116:146–158, 15936888PubMedCrossRef
18.
go back to reference Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12, 8721797, 1:STN:280:DyaK28zgvVCmug%3D%3DPubMedCrossRef Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12, 8721797, 1:STN:280:DyaK28zgvVCmug%3D%3DPubMedCrossRef
19.
go back to reference Kendall JM (2003) Designing a research project: randomised controlled trials and their principles. Emerg Med J 20:164–168, 12642531, 1:STN:280:DC%2BD3s7isl2nsw%3D%3DPubMedCentralPubMedCrossRef Kendall JM (2003) Designing a research project: randomised controlled trials and their principles. Emerg Med J 20:164–168, 12642531, 1:STN:280:DC%2BD3s7isl2nsw%3D%3DPubMedCentralPubMedCrossRef
20.
go back to reference Reeves BC (2003) Principles of research: limitations of non-randomized studies. Surgery 21:129–133 Reeves BC (2003) Principles of research: limitations of non-randomized studies. Surgery 21:129–133
21.
go back to reference Schulz KF, Grimes DA (2005) Multiplicity in randomised trials I: endpoints and treatments. Lancet 365:1591–1595, 15866314PubMedCrossRef Schulz KF, Grimes DA (2005) Multiplicity in randomised trials I: endpoints and treatments. Lancet 365:1591–1595, 15866314PubMedCrossRef
22.
go back to reference Macedo A, Farré M, Baños JE (2006) A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials. Eur J Clin Pharmacol 62:161–172, 16402240PubMedCrossRef Macedo A, Farré M, Baños JE (2006) A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials. Eur J Clin Pharmacol 62:161–172, 16402240PubMedCrossRef
23.
go back to reference Deeks JJ, Altman DG (1998) Inadequate reporting of controlled trials as short reports. Lancet 352:1908, 9863796, 1:STN:280:DyaK1M%2FnvFGjsg%3D%3DPubMedCrossRef Deeks JJ, Altman DG (1998) Inadequate reporting of controlled trials as short reports. Lancet 352:1908, 9863796, 1:STN:280:DyaK1M%2FnvFGjsg%3D%3DPubMedCrossRef
24.
go back to reference Rosmarakis ES, Soteriades ES, Vergidis PI, Kasiakou SK, Falagas ME (2005) From conference abstract to full paper: differences between data presented in conferences and journals. FASEB J 19:673–680, 15857882, 1:CAS:528:DC%2BD2MXktVKmu74%3DPubMedCrossRef Rosmarakis ES, Soteriades ES, Vergidis PI, Kasiakou SK, Falagas ME (2005) From conference abstract to full paper: differences between data presented in conferences and journals. FASEB J 19:673–680, 15857882, 1:CAS:528:DC%2BD2MXktVKmu74%3DPubMedCrossRef
25.
go back to reference Evans M, Pollock A (1985) A score system for evaluating random control clinical trials of prophylaxis of abdominal surgical wound infection. Br J Surg 72:256–260, 3986472, 1:STN:280:DyaL2M7nsFOksw%3D%3DPubMedCrossRef Evans M, Pollock A (1985) A score system for evaluating random control clinical trials of prophylaxis of abdominal surgical wound infection. Br J Surg 72:256–260, 3986472, 1:STN:280:DyaL2M7nsFOksw%3D%3DPubMedCrossRef
26.
go back to reference Snow V, Weiss K, Wall EM, Mottur-Pilson C (2002) Pharmacologic management of acute attacks of migraine and prevention of migraine headache. Ann Intern Med 137:840–849, 12435222, 1:CAS:528:DC%2BD38Xptlajur0%3DPubMedCrossRef Snow V, Weiss K, Wall EM, Mottur-Pilson C (2002) Pharmacologic management of acute attacks of migraine and prevention of migraine headache. Ann Intern Med 137:840–849, 12435222, 1:CAS:528:DC%2BD38Xptlajur0%3DPubMedCrossRef
27.
go back to reference Silberstein SD, Rosenberg J (2000) Multispeciality consensus on diagnosis and treatment of headache. Neurology 54:1553, 10762491, 1:STN:280:DC%2BD3c3islymtw%3D%3DPubMedCrossRef Silberstein SD, Rosenberg J (2000) Multispeciality consensus on diagnosis and treatment of headache. Neurology 54:1553, 10762491, 1:STN:280:DC%2BD3c3islymtw%3D%3DPubMedCrossRef
28.
go back to reference Berman NG, Parker RA (2002) Meta-analysis: Neither quick nor easy. BMC Medical Res Methodol 2:(10)1–9 Berman NG, Parker RA (2002) Meta-analysis: Neither quick nor easy. BMC Medical Res Methodol 2:(10)1–9
29.
go back to reference Kjaergard LL, Villumsen J, Gluud C (2001) Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135:982–989, 11730399, 1:STN:280:DC%2BD3MnovVygsg%3D%3DPubMedCrossRef Kjaergard LL, Villumsen J, Gluud C (2001) Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135:982–989, 11730399, 1:STN:280:DC%2BD3MnovVygsg%3D%3DPubMedCrossRef
30.
go back to reference European Agency for the Evaluation of Medicinal Products (EMEA): points to consider on switching between superiority and non-inferiority. London, CPMP/EWP/482/99, July 2000 European Agency for the Evaluation of Medicinal Products (EMEA): points to consider on switching between superiority and non-inferiority. London, CPMP/EWP/482/99, July 2000
31.
go back to reference European Medicines Agency (EMEA): guideline on the choice of the non-inferiority margin. London, EMEA/CPMP/EWP/2158/99, July 2005 European Medicines Agency (EMEA): guideline on the choice of the non-inferiority margin. London, EMEA/CPMP/EWP/2158/99, July 2005
32.
go back to reference Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B, Lipton RB (2009) Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics. Cephalalgia 29:188–193, 18823361PubMedCrossRef Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B, Lipton RB (2009) Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics. Cephalalgia 29:188–193, 18823361PubMedCrossRef
33.
go back to reference Bigal ME, Bordini CA, Speciali JG (2002) Efficacy of three drugs in the treatment of migrainous aura: a randomized placebo-controlled study. Arqu Neuro-psiquiatr 60(2-B):406–409 Bigal ME, Bordini CA, Speciali JG (2002) Efficacy of three drugs in the treatment of migrainous aura: a randomized placebo-controlled study. Arqu Neuro-psiquiatr 60(2-B):406–409
34.
go back to reference Bomhof M, Paz J, Legg N, Allen C, Vandormael K, Patel K (1999) Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine. Eur Neurol 42:173–179, 10529545, 1:CAS:528:DyaK1MXnvVGgs7k%3DPubMedCrossRef Bomhof M, Paz J, Legg N, Allen C, Vandormael K, Patel K (1999) Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine. Eur Neurol 42:173–179, 10529545, 1:CAS:528:DyaK1MXnvVGgs7k%3DPubMedCrossRef
35.
go back to reference Danesch U, Rittinghausen R (2003) Safety of a patented special butterbur root extract for migraine prevention. Headache 43:76–78, 12864764PubMedCrossRef Danesch U, Rittinghausen R (2003) Safety of a patented special butterbur root extract for migraine prevention. Headache 43:76–78, 12864764PubMedCrossRef
36.
go back to reference Diener HC, Rahlfs VW, Danesch U (2004) The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 51:89–97, 14752215, 1:STN:280:DC%2BD2c7htFWmug%3D%3DPubMedCrossRef Diener HC, Rahlfs VW, Danesch U (2004) The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 51:89–97, 14752215, 1:STN:280:DC%2BD2c7htFWmug%3D%3DPubMedCrossRef
37.
go back to reference Diener HC, Bussone G, de Liano H, Eikermann A, Englert R, Floeter T, Gallai V, Göbel H, Hartung E, Jimenez MD, Lange R, Manzoni GC, Mueller-Schwefe G, Nappi G, Pinessi L, Prat J, Puca FM, Titus F, Voelker M (2004) EMSASI Study Group. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia 24:947–954, 15482357, 1:STN:280:DC%2BD2crht1Ciuw%3D%3DPubMedCrossRef Diener HC, Bussone G, de Liano H, Eikermann A, Englert R, Floeter T, Gallai V, Göbel H, Hartung E, Jimenez MD, Lange R, Manzoni GC, Mueller-Schwefe G, Nappi G, Pinessi L, Prat J, Puca FM, Titus F, Voelker M (2004) EMSASI Study Group. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks. Cephalalgia 24:947–954, 15482357, 1:STN:280:DC%2BD2crht1Ciuw%3D%3DPubMedCrossRef
38.
go back to reference Diener HC, Eikermann A, Gessner U, Göbel H, Haag G, Lange R, May A, Müller-Schwefe G, Voelker M (2004) Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms. Eur Neurol 52:50–56, 15240983, 1:CAS:528:DC%2BD2cXmsV2itrw%3DPubMedCrossRef Diener HC, Eikermann A, Gessner U, Göbel H, Haag G, Lange R, May A, Müller-Schwefe G, Voelker M (2004) Efficacy of 1,000 mg effervescent acetylsalicylic acid and sumatriptan in treating associated migraine symptoms. Eur Neurol 52:50–56, 15240983, 1:CAS:528:DC%2BD2cXmsV2itrw%3DPubMedCrossRef
39.
go back to reference Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B (2005) The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 25:776–787, 16162254, 1:STN:280:DC%2BD2MvptFGqtg%3D%3DPubMedCrossRef Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B (2005) The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study. Cephalalgia 25:776–787, 16162254, 1:STN:280:DC%2BD2MvptFGqtg%3D%3DPubMedCrossRef
40.
go back to reference Garcia-Ramos G, MacGregor EA, Hilliard B, Bordini CA, Leston J, Hettiarachchi J (2003) Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. Cephalalgia 23:869–876, 14616928, 1:STN:280:DC%2BD3srlsFegug%3D%3DPubMedCrossRef Garcia-Ramos G, MacGregor EA, Hilliard B, Bordini CA, Leston J, Hettiarachchi J (2003) Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. Cephalalgia 23:869–876, 14616928, 1:STN:280:DC%2BD3srlsFegug%3D%3DPubMedCrossRef
41.
go back to reference Göbel H, Heinze A, Dworschak M, Heinze-Kuhn K, Stolze H (2004) Oleum menthae piperitae in der Akuttherapie von Migräne und Kopfschmerz vom Spannungstyp. Z Phytother 25:129–139 Göbel H, Heinze A, Dworschak M, Heinze-Kuhn K, Stolze H (2004) Oleum menthae piperitae in der Akuttherapie von Migräne und Kopfschmerz vom Spannungstyp. Z Phytother 25:129–139
42.
go back to reference Göbel H, Heinze A, Niederberger U, Witt T, Zumbroich V (2004) Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study. Cephalalgia 24:888–893, 15377321PubMedCrossRef Göbel H, Heinze A, Niederberger U, Witt T, Zumbroich V (2004) Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study. Cephalalgia 24:888–893, 15377321PubMedCrossRef
43.
go back to reference Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J (2005) Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. Headache 45:973–982, 16109110PubMedCrossRef Goldstein J, Silberstein SD, Saper JR, Elkind AH, Smith TR, Gallagher RM, Battikha JP, Hoffman H, Baggish J (2005) Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial. Headache 45:973–982, 16109110PubMedCrossRef
44.
go back to reference Goldstein J, Silberstein SD, Saper JR, Ryan RE, Lipton RB (2006) Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 46:444–453, 16618262PubMedCrossRef Goldstein J, Silberstein SD, Saper JR, Ryan RE, Lipton RB (2006) Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 46:444–453, 16618262PubMedCrossRef
45.
go back to reference Grigorova NA, Leshchenko OK (2003) Current aspects of the treatment of migraine. Likarska Sprava 5–6:80–85 Grigorova NA, Leshchenko OK (2003) Current aspects of the treatment of migraine. Likarska Sprava 5–6:80–85
46.
go back to reference Haas DC, Sheehe PR (2004) Dextroamphetamine pilot crossover trials and n of 1 trials in patients with chronic tension-type and migraine headache. Headache 44:1029–1037, 15546268PubMedCrossRef Haas DC, Sheehe PR (2004) Dextroamphetamine pilot crossover trials and n of 1 trials in patients with chronic tension-type and migraine headache. Headache 44:1029–1037, 15546268PubMedCrossRef
47.
go back to reference Havanka H, Dahlöf C, Pop PH, Diener HC, Winter P, Whitehouse H, Hassani H (2000) Efficacy of naratriptan tablets in the acute treatment of migraine: a dose-ranging study. Naratriptan S2WB2004 Study Group. Clin Therap 22:970–980, 1:CAS:528:DC%2BD3cXmsFSqtLw%3DCrossRef Havanka H, Dahlöf C, Pop PH, Diener HC, Winter P, Whitehouse H, Hassani H (2000) Efficacy of naratriptan tablets in the acute treatment of migraine: a dose-ranging study. Naratriptan S2WB2004 Study Group. Clin Therap 22:970–980, 1:CAS:528:DC%2BD3cXmsFSqtLw%3DCrossRef
48.
go back to reference Klassen A, Elkind A, Asgharnejad M, Webster C, Laurenza A (1997) Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo-controlled, parallel-group study. Naratriptan S2WA3001 Study Group. Headache 37:640–645, 9439085, 1:STN:280:DyaK1c7gt1SksA%3D%3DPubMedCrossRef Klassen A, Elkind A, Asgharnejad M, Webster C, Laurenza A (1997) Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo-controlled, parallel-group study. Naratriptan S2WA3001 Study Group. Headache 37:640–645, 9439085, 1:STN:280:DyaK1c7gt1SksA%3D%3DPubMedCrossRef
49.
go back to reference Kubitzek F, Ziegler G, Gold ML, Liu JMH, Ionescu E (2003) Low-dose diclofenac potassium in the treatment of episodic tension-type headache. Eur J Pain 7:155–162, 12600797, 1:CAS:528:DC%2BD3sXhsFGgtLo%3DPubMedCrossRef Kubitzek F, Ziegler G, Gold ML, Liu JMH, Ionescu E (2003) Low-dose diclofenac potassium in the treatment of episodic tension-type headache. Eur J Pain 7:155–162, 12600797, 1:CAS:528:DC%2BD3sXhsFGgtLo%3DPubMedCrossRef
50.
go back to reference Lewis DW, Kellstein D, Dahl G, Burke B, Frank LM, Toor S, Northam RS, White LW, Lawson L (2002) Children’s ibuprofen suspension for the acute treatment of pediatric migraine. Headache 42:780–786, 12390641PubMedCrossRef Lewis DW, Kellstein D, Dahl G, Burke B, Frank LM, Toor S, Northam RS, White LW, Lawson L (2002) Children’s ibuprofen suspension for the acute treatment of pediatric migraine. Headache 42:780–786, 12390641PubMedCrossRef
51.
go back to reference Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 63:2240–2244, 15623680, 1:STN:280:DC%2BD2cnkslWjsw%3D%3DPubMedCrossRef Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A (2004) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 63:2240–2244, 15623680, 1:STN:280:DC%2BD2cnkslWjsw%3D%3DPubMedCrossRef
52.
go back to reference Lipton RB, Goldstein J, Baggish JS, Yataco AR, Sorrentino JV, Quiring JN (2005) Aspirin is efficacious for the treatment of acute migraine. Headache 45:283–292, 15836564PubMedCrossRef Lipton RB, Goldstein J, Baggish JS, Yataco AR, Sorrentino JV, Quiring JN (2005) Aspirin is efficacious for the treatment of acute migraine. Headache 45:283–292, 15836564PubMedCrossRef
53.
go back to reference MacGregor EA, Dowson A, Davies PT (2002) Mouth-dispersible aspirin in the treatment of migraine: a placebo-controlled study. Headache 42:249–255, 12010380PubMedCrossRef MacGregor EA, Dowson A, Davies PT (2002) Mouth-dispersible aspirin in the treatment of migraine: a placebo-controlled study. Headache 42:249–255, 12010380PubMedCrossRef
54.
go back to reference Massiou H, Jamin C, Hinzelin G, Bidaut-Mazel C (2005) The French Naramig Collaborative Study Group. Efficacy of oral Naratriptan in the treatment of menstrually related migraine. Eur J Neurol 12:774–781, 16190915, 1:STN:280:DC%2BD2MrhvVGhtA%3D%3DPubMedCrossRef Massiou H, Jamin C, Hinzelin G, Bidaut-Mazel C (2005) The French Naramig Collaborative Study Group. Efficacy of oral Naratriptan in the treatment of menstrually related migraine. Eur J Neurol 12:774–781, 16190915, 1:STN:280:DC%2BD2MrhvVGhtA%3D%3DPubMedCrossRef
55.
go back to reference Mathew NT, Asgharnejad M, Peykamian M, Laurenza A, Naratriptan is effective, well tolerated in the acute treatment of migraine (1997) Results of a double-blind, placebo-controlled, crossover study. The Naratriptan S2WA3003 Study Group. Neurology 49:1485–1490, 9409334, 1:CAS:528:DyaK1cXitVChuw%3D%3DPubMedCrossRef Mathew NT, Asgharnejad M, Peykamian M, Laurenza A, Naratriptan is effective, well tolerated in the acute treatment of migraine (1997) Results of a double-blind, placebo-controlled, crossover study. The Naratriptan S2WA3003 Study Group. Neurology 49:1485–1490, 9409334, 1:CAS:528:DyaK1cXitVChuw%3D%3DPubMedCrossRef
56.
go back to reference Migliardi JR, Armellino JJ, Friedman M, Gillings DB, Beaver WT (1994) Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 56:576–586, 7955822, 1:STN:280:DyaK2M%2FktlymtA%3D%3DPubMedCrossRef Migliardi JR, Armellino JJ, Friedman M, Gillings DB, Beaver WT (1994) Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 56:576–586, 7955822, 1:STN:280:DyaK2M%2FktlymtA%3D%3DPubMedCrossRef
57.
go back to reference Misra UK, Jose M, Kalita J (2004) Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial. Postgrad Med J 80:720–723, 15579612, 1:CAS:528:DC%2BD2MXktlGqsA%3D%3DPubMedCentralPubMedCrossRef Misra UK, Jose M, Kalita J (2004) Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial. Postgrad Med J 80:720–723, 15579612, 1:CAS:528:DC%2BD2MXktlGqsA%3D%3DPubMedCentralPubMedCrossRef
58.
go back to reference Philipp M (1977) Therapy of migraine. Clinical experience with Migraeflux, a new migraine drug. Fortschr Med 95:107–110, 832830, 1:STN:280:DyaE2s%2Fpt1KitQ%3D%3DPubMed Philipp M (1977) Therapy of migraine. Clinical experience with Migraeflux, a new migraine drug. Fortschr Med 95:107–110, 832830, 1:STN:280:DyaE2s%2Fpt1KitQ%3D%3DPubMed
59.
go back to reference Pothmann R, Danesch U (2005) Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache 45:196–203, 15836592PubMedCrossRef Pothmann R, Danesch U (2005) Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache 45:196–203, 15836592PubMedCrossRef
60.
go back to reference Saper J, Dahlöf C, So Y, Tfelt-Hansen P, Malbecq W, Loeys T, Barraclough E, Klipfel M, Lines C, Visser H, Reines S, Yuen E (2006) Rofecoxib Protocol 162 Study Group. Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial. Headache 46:264–275, 16492236PubMedCrossRef Saper J, Dahlöf C, So Y, Tfelt-Hansen P, Malbecq W, Loeys T, Barraclough E, Klipfel M, Lines C, Visser H, Reines S, Yuen E (2006) Rofecoxib Protocol 162 Study Group. Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial. Headache 46:264–275, 16492236PubMedCrossRef
61.
go back to reference Stark S, Spierings EL, McNeal S, Putnam GP, Bolden-Watson CP, O’Quinn S (2000) Naratriptan efficacy in migraineurs who respond poorly to oral sumatriptan. Headache 40:513–520, 10940089, 1:STN:280:DC%2BD3M%2Fls1ahtA%3D%3DPubMedCrossRef Stark S, Spierings EL, McNeal S, Putnam GP, Bolden-Watson CP, O’Quinn S (2000) Naratriptan efficacy in migraineurs who respond poorly to oral sumatriptan. Headache 40:513–520, 10940089, 1:STN:280:DC%2BD3M%2Fls1ahtA%3D%3DPubMedCrossRef
62.
go back to reference Steiner TJ, Lange R (1998) Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type headache: double-blind placebo-controlled comparison with acetaminophen (1,000 mg). Cephalalgia 18:38–43, 9601623, 1:STN:280:DyaK1c3mtl2huw%3D%3DPubMedCrossRef Steiner TJ, Lange R (1998) Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type headache: double-blind placebo-controlled comparison with acetaminophen (1,000 mg). Cephalalgia 18:38–43, 9601623, 1:STN:280:DyaK1c3mtl2huw%3D%3DPubMedCrossRef
63.
go back to reference Steiner TJ, Lange R, Voelker M (2003) Aspirin in episodic tension-type headache: placebo-controlled dose-ranging comparison with paracetamol. Cephalalgia 23:59–66, 12534583, 1:STN:280:DC%2BD3s%2FmvFensg%3D%3DPubMedCrossRef Steiner TJ, Lange R, Voelker M (2003) Aspirin in episodic tension-type headache: placebo-controlled dose-ranging comparison with paracetamol. Cephalalgia 23:59–66, 12534583, 1:STN:280:DC%2BD3s%2FmvFensg%3D%3DPubMedCrossRef
64.
go back to reference Suthisisang C, Poolsup N, Kittikulsuth W, Pudchakan P, Wiwatpanich P (2007) Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother 41:1782–1791, 17878396, 1:CAS:528:DC%2BD2sXhtlGrtb7PPubMedCrossRef Suthisisang C, Poolsup N, Kittikulsuth W, Pudchakan P, Wiwatpanich P (2007) Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. Ann Pharmacother 41:1782–1791, 17878396, 1:CAS:528:DC%2BD2sXhtlGrtb7PPubMedCrossRef
65.
go back to reference Wang F, Van Den Eeden SK, Ackerson LM, Salk SE, Reince RH, Elin RJ (2003) Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 43:601–610, 12786918PubMedCrossRef Wang F, Van Den Eeden SK, Ackerson LM, Salk SE, Reince RH, Elin RJ (2003) Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 43:601–610, 12786918PubMedCrossRef
66.
go back to reference Zukerman E, Negro MHS, Nothen MR (1990) Comparative study on the efficacy and tolerability of different formulations for Tonopan versus placebo in migraine. Rev Bras Neurol 26:57–60 Zukerman E, Negro MHS, Nothen MR (1990) Comparative study on the efficacy and tolerability of different formulations for Tonopan versus placebo in migraine. Rev Bras Neurol 26:57–60
67.
go back to reference Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gøtzsche PC, Lang T, for the CONSORT group (2002) The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134:663–694CrossRef Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gøtzsche PC, Lang T, for the CONSORT group (2002) The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134:663–694CrossRef
68.
go back to reference Chan AW, Hrobjartsson A, Haahr MT, Gøtzsche PC, Altman DG (2004) Empirical evidence for selective reporting of outcomes in randomized trials—comparison of protocols to published articles. JAMA 291:2457–2465, 15161896, 1:CAS:528:DC%2BD2cXksVegsL4%3DPubMedCrossRef Chan AW, Hrobjartsson A, Haahr MT, Gøtzsche PC, Altman DG (2004) Empirical evidence for selective reporting of outcomes in randomized trials—comparison of protocols to published articles. JAMA 291:2457–2465, 15161896, 1:CAS:528:DC%2BD2cXksVegsL4%3DPubMedCrossRef
70.
go back to reference Gracely E (2008) So, why do I have to correct for multiple comparisons? Concepts and commentary on Turk et al. Pain 139:481–482, 18838224PubMedCrossRef Gracely E (2008) So, why do I have to correct for multiple comparisons? Concepts and commentary on Turk et al. Pain 139:481–482, 18838224PubMedCrossRef
71.
go back to reference Turk DC, Dworkin RH, McDermott MP et al (2008) Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations. Pain 139:485–493, 18706763PubMedCrossRef Turk DC, Dworkin RH, McDermott MP et al (2008) Analyzing multiple endpoints in clinical trials of pain treatments: IMMPACT recommendations. Pain 139:485–493, 18706763PubMedCrossRef
72.
go back to reference Driscoll P, Lecky F, Crosby M (2000) An introduction to everyday statistics. Part 1. J Accid Emerg Med 17:205–211, 10819386, 1:STN:280:DC%2BD3czpt1Whug%3D%3DPubMedCrossRef Driscoll P, Lecky F, Crosby M (2000) An introduction to everyday statistics. Part 1. J Accid Emerg Med 17:205–211, 10819386, 1:STN:280:DC%2BD3czpt1Whug%3D%3DPubMedCrossRef
73.
go back to reference Moher D, Dulberg CS, Wells GA (1994) Statistical power, sample size, and their reporting in randomized controlled trials. JAMA 272:122–124, 8015121, 1:STN:280:DyaK2c3osFemtQ%3D%3DPubMedCrossRef Moher D, Dulberg CS, Wells GA (1994) Statistical power, sample size, and their reporting in randomized controlled trials. JAMA 272:122–124, 8015121, 1:STN:280:DyaK2c3osFemtQ%3D%3DPubMedCrossRef
74.
go back to reference Halpern SD, Karlawish JHT, Berlin JA (2002) The continuing unethical conduct of underpowered clinical trials. JAMA 288:358–362, 12117401PubMedCrossRef Halpern SD, Karlawish JHT, Berlin JA (2002) The continuing unethical conduct of underpowered clinical trials. JAMA 288:358–362, 12117401PubMedCrossRef
75.
go back to reference Gardner MJ, Altman DG (1986) Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J 292:746–750, 1:STN:280:DyaL287mtVOjug%3D%3DCrossRef Gardner MJ, Altman DG (1986) Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J 292:746–750, 1:STN:280:DyaL287mtVOjug%3D%3DCrossRef
76.
go back to reference Gehr BT, Weiss C, Porzsolt F (2006) The fading of reported effectiveness. A meta-analysis of randomised controlled trials. BMC Med Res Methodol 6:25. doi:10.1186/1471-2288-6-25 Gehr BT, Weiss C, Porzsolt F (2006) The fading of reported effectiveness. A meta-analysis of randomised controlled trials. BMC Med Res Methodol 6:25. doi:10.​1186/​1471-2288-6-25
77.
go back to reference Pray WS (2006) Nonprescription medications and self care. Ethical, scientific, and educational concerns with unproven medications. Am J Pharm Educ 70(141):1–13 Pray WS (2006) Nonprescription medications and self care. Ethical, scientific, and educational concerns with unproven medications. Am J Pharm Educ 70(141):1–13
79.
go back to reference Martelletti P, Farinelli I, Coloprisco G, Patacchioli FR (2007) Role of NSAIDs in acute treatment of headache. Drug Dev Res 68:276–281, 1:CAS:528:DC%2BD1cXhtFaqt7s%3DCrossRef Martelletti P, Farinelli I, Coloprisco G, Patacchioli FR (2007) Role of NSAIDs in acute treatment of headache. Drug Dev Res 68:276–281, 1:CAS:528:DC%2BD1cXhtFaqt7s%3DCrossRef
80.
go back to reference Tfelt-Hansen P, Bjarnason NH, Dahlöf C, Derry S, Loder E, Massiou H, Task force on adverse events in migraine trials of the subcommittee on clinical trial of the International Headache Society (2008) Evaluation and registration of adverse events in clinical drug trials in migraine. Cephalalgia 28:683–688, 18498392, 1:STN:280:DC%2BD1cznvVartA%3D%3DPubMedCrossRef Tfelt-Hansen P, Bjarnason NH, Dahlöf C, Derry S, Loder E, Massiou H, Task force on adverse events in migraine trials of the subcommittee on clinical trial of the International Headache Society (2008) Evaluation and registration of adverse events in clinical drug trials in migraine. Cephalalgia 28:683–688, 18498392, 1:STN:280:DC%2BD1cznvVartA%3D%3DPubMedCrossRef
81.
go back to reference Evers S, May A, Fritsche G, Kropp P, Lampl C, Limmroth V, Malzacher V, Sandor P, Straube A, Diener HC (2008) Akuttherapie und Prophylaxe der Migräne—Leitlinie der Deutschen Migräne-und Kopfschmerzgesellschaft und der Deutschen Gesellschaft für Neurologie. Nervenheilkunde 27:933–949 Evers S, May A, Fritsche G, Kropp P, Lampl C, Limmroth V, Malzacher V, Sandor P, Straube A, Diener HC (2008) Akuttherapie und Prophylaxe der Migräne—Leitlinie der Deutschen Migräne-und Kopfschmerzgesellschaft und der Deutschen Gesellschaft für Neurologie. Nervenheilkunde 27:933–949
82.
go back to reference Diener HC, Lampl C, Reimitz P, Voelker M (2006) Aspirin in the treatment of acute migraine attacks. Expert Rev Neurotherap 6:563–573, 1:CAS:528:DC%2BD28XkvFKhtL4%3DCrossRef Diener HC, Lampl C, Reimitz P, Voelker M (2006) Aspirin in the treatment of acute migraine attacks. Expert Rev Neurotherap 6:563–573, 1:CAS:528:DC%2BD28XkvFKhtL4%3DCrossRef
83.
go back to reference Pageler L, Diener HC, Pfaffenrath V, Peil H, Aicher B (2009) Clinical relevance of efficacy endpoints in OTC trials. Headache 49:646–654, 19472440PubMedCrossRef Pageler L, Diener HC, Pfaffenrath V, Peil H, Aicher B (2009) Clinical relevance of efficacy endpoints in OTC trials. Headache 49:646–654, 19472440PubMedCrossRef
84.
go back to reference Bergmann JF (2003) Self-medication: from European regulatory directives to therapeutic strategy. Fundam Clin Pharmacol 17:275–280, 12803567, 1:CAS:528:DC%2BD3sXltFamurY%3DPubMedCrossRef Bergmann JF (2003) Self-medication: from European regulatory directives to therapeutic strategy. Fundam Clin Pharmacol 17:275–280, 12803567, 1:CAS:528:DC%2BD3sXltFamurY%3DPubMedCrossRef
85.
go back to reference Grossman M, Schmidramsl H (2000) An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 38:430–435CrossRef Grossman M, Schmidramsl H (2000) An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Ther 38:430–435CrossRef
86.
go back to reference Packman B, Packman E, Doyle G, Cooper S, Ashraf E, Koronkiewicz K, Jayawardena S (2000) Solubilized ibuprofen: evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache. Headache 40:561–567, 10940094, 1:STN:280:DC%2BD3M%2Fls1agsw%3D%3DPubMedCrossRef Packman B, Packman E, Doyle G, Cooper S, Ashraf E, Koronkiewicz K, Jayawardena S (2000) Solubilized ibuprofen: evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache. Headache 40:561–567, 10940094, 1:STN:280:DC%2BD3M%2Fls1agsw%3D%3DPubMedCrossRef
87.
go back to reference Hofmann R (2008) More to be said on “Triptans vs other drugs for acute migraine. Are there differences in efficacy?”. Headache 49:312–313, 18783444PubMed Hofmann R (2008) More to be said on “Triptans vs other drugs for acute migraine. Are there differences in efficacy?”. Headache 49:312–313, 18783444PubMed
88.
go back to reference Glasser SP, Salas M, Delzell E (2007) Importance and challenges of studying marketed drugs: what is a phase IV study? Common clinical research designs, registries, and self-reporting systems. J Clin Pharmacol 47:1074–1086, 17766697PubMedCrossRef Glasser SP, Salas M, Delzell E (2007) Importance and challenges of studying marketed drugs: what is a phase IV study? Common clinical research designs, registries, and self-reporting systems. J Clin Pharmacol 47:1074–1086, 17766697PubMedCrossRef
89.
go back to reference Moore N, Van Ganse E, Le Parc JM, Wall R, Schneid H, Farhan M, Verirere F, Pelen F (1999) The PAIN study: paracetamol, aspirin and ibuprofen new tolerability study. Clin Drug Invest 18:89–98, 1:CAS:528:DyaK1MXlvVansrs%3DCrossRef Moore N, Van Ganse E, Le Parc JM, Wall R, Schneid H, Farhan M, Verirere F, Pelen F (1999) The PAIN study: paracetamol, aspirin and ibuprofen new tolerability study. Clin Drug Invest 18:89–98, 1:CAS:528:DyaK1MXlvVansrs%3DCrossRef
90.
go back to reference Andrade SE, Martinez C, Walker AM (1998) Comparative safety evaluation of non-narcotic analgesics. J Clin Epidemiol 51:1357–1365, 10086830, 1:STN:280:DyaK1M7osVKgtg%3D%3DPubMedCrossRef Andrade SE, Martinez C, Walker AM (1998) Comparative safety evaluation of non-narcotic analgesics. J Clin Epidemiol 51:1357–1365, 10086830, 1:STN:280:DyaK1M7osVKgtg%3D%3DPubMedCrossRef
91.
go back to reference Feleppa M, Apice G, D’Alessio A, Fucci S, Bigal ME (2008) Tolerability of acute migraine medications: influence of methods of assessment and relationship with headache attributes. Cephalalgia 28:1012–1016, 18727650, 1:STN:280:DC%2BD1cnjt1agsQ%3D%3DPubMedCrossRef Feleppa M, Apice G, D’Alessio A, Fucci S, Bigal ME (2008) Tolerability of acute migraine medications: influence of methods of assessment and relationship with headache attributes. Cephalalgia 28:1012–1016, 18727650, 1:STN:280:DC%2BD1cnjt1agsQ%3D%3DPubMedCrossRef
92.
go back to reference McQuay H, Moore A (1998) An evidence-based resource for pain relief. Oxford University Press, Oxford McQuay H, Moore A (1998) An evidence-based resource for pain relief. Oxford University Press, Oxford
93.
go back to reference West RR (2000) Evidence based medicine overviews, bulletins, guidelines, and the new consensus. Postgrad Med J 76:383–389, 10878193, 1:STN:280:DC%2BD3cvit1Cmug%3D%3DPubMedCentralPubMedCrossRef West RR (2000) Evidence based medicine overviews, bulletins, guidelines, and the new consensus. Postgrad Med J 76:383–389, 10878193, 1:STN:280:DC%2BD3cvit1Cmug%3D%3DPubMedCentralPubMedCrossRef
94.
go back to reference Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G (1991) Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 31:298–301, 1860787, 1:STN:280:DyaK3MzhslKmtw%3D%3DPubMedCrossRef Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G (1991) Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 31:298–301, 1860787, 1:STN:280:DyaK3MzhslKmtw%3D%3DPubMedCrossRef
95.
go back to reference Peikert A, Willimzig C, Kohne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 16:257–263, 8792038, 1:STN:280:DyaK28zosVWnsw%3D%3DPubMedCrossRef Peikert A, Willimzig C, Kohne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 16:257–263, 8792038, 1:STN:280:DyaK28zosVWnsw%3D%3DPubMedCrossRef
96.
go back to reference Pfaffenrath V, Wessely P, Meyer C, Isler H, Evers S, Grotemeyer KH, Taneri Z, Soyka D, Göbel H, Fischer M (1996) Magnesium in the prophylaxis of migraine. A double-blind, placebo-controlled study. Cephalalgia 16:436–440, 8902254, 1:STN:280:DyaK2s%2Flsl2htg%3D%3DPubMedCrossRef Pfaffenrath V, Wessely P, Meyer C, Isler H, Evers S, Grotemeyer KH, Taneri Z, Soyka D, Göbel H, Fischer M (1996) Magnesium in the prophylaxis of migraine. A double-blind, placebo-controlled study. Cephalalgia 16:436–440, 8902254, 1:STN:280:DyaK2s%2Flsl2htg%3D%3DPubMedCrossRef
97.
go back to reference Hershey AD, Powers SW, Vockell AL, Lecates SL, Ellinor PL, Segers A, Burdine D, Manning P, Kabbouche MA (2007) Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 47:73–80, 17355497PubMedCrossRef Hershey AD, Powers SW, Vockell AL, Lecates SL, Ellinor PL, Segers A, Burdine D, Manning P, Kabbouche MA (2007) Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache 47:73–80, 17355497PubMedCrossRef
98.
go back to reference Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD (2002) Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 22:137–141, 11972582, 1:STN:280:DC%2BD383lsVyisA%3D%3DPubMedCrossRef Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD (2002) Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia 22:137–141, 11972582, 1:STN:280:DC%2BD383lsVyisA%3D%3DPubMedCrossRef
99.
go back to reference Sandor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J (2005) Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 64:713–715, 15728298, 1:CAS:528:DC%2BD2MXpsFyqtw%3D%3DPubMedCrossRef Sandor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J (2005) Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 64:713–715, 15728298, 1:CAS:528:DC%2BD2MXpsFyqtw%3D%3DPubMedCrossRef
100.
go back to reference Maizels M, Blumenfeld A, Burchette R (2004) A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 44:885–890, 15447697PubMedCrossRef Maizels M, Blumenfeld A, Burchette R (2004) A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache 44:885–890, 15447697PubMedCrossRef
101.
go back to reference Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G (2004) High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol 11:475–477, 15257686, 1:STN:280:DC%2BD2czlsFWhuw%3D%3DPubMedCrossRef Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G (2004) High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol 11:475–477, 15257686, 1:STN:280:DC%2BD2czlsFWhuw%3D%3DPubMedCrossRef
102.
go back to reference Schoenen J, Lenaerts M, Bastings E (1994) High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia 14:328–329, 7828189, 1:STN:280:DyaK2M7ivFWjsg%3D%3DPubMedCrossRef Schoenen J, Lenaerts M, Bastings E (1994) High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia 14:328–329, 7828189, 1:STN:280:DyaK2M7ivFWjsg%3D%3DPubMedCrossRef
103.
go back to reference Schoenen J, Jacquy J, Lenaerts M (1998) Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 50:466–470, 9484373, 1:CAS:528:DyaK1cXhsl2jtbo%3DPubMedCrossRef Schoenen J, Jacquy J, Lenaerts M (1998) Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 50:466–470, 9484373, 1:CAS:528:DyaK1cXhsl2jtbo%3DPubMedCrossRef
104.
go back to reference Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J (2007) A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 47:52–57, 17355494PubMedCrossRef Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J (2007) A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 47:52–57, 17355494PubMedCrossRef
105.
go back to reference Pradalier A, Bakouche P, Baudesson G, Delage A, Cornaille-Lafage G, Launay JM, Biason P (2001) Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia 21:818–822, 11737007, 1:STN:280:DC%2BD3MnpsVCitQ%3D%3DPubMedCrossRef Pradalier A, Bakouche P, Baudesson G, Delage A, Cornaille-Lafage G, Launay JM, Biason P (2001) Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. Cephalalgia 21:818–822, 11737007, 1:STN:280:DC%2BD3MnpsVCitQ%3D%3DPubMedCrossRef
106.
go back to reference Peres MFP, Zukerman E, da Cunha Tanuri F, Moreira FR, Cipolla-Neto J (2004) Melatonin, 3 mg, is effective for migraine prevention. Neurology 63:757, 15326268, 1:STN:280:DC%2BD2cvhvF2msA%3D%3DPubMedCrossRef Peres MFP, Zukerman E, da Cunha Tanuri F, Moreira FR, Cipolla-Neto J (2004) Melatonin, 3 mg, is effective for migraine prevention. Neurology 63:757, 15326268, 1:STN:280:DC%2BD2cvhvF2msA%3D%3DPubMedCrossRef
107.
go back to reference Peres MF (2005) Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia 25:403–411, 15910564, 1:STN:280:DC%2BD2M3mvVGisw%3D%3DPubMedCrossRef Peres MF (2005) Melatonin, the pineal gland and their implications for headache disorders. Cephalalgia 25:403–411, 15910564, 1:STN:280:DC%2BD2M3mvVGisw%3D%3DPubMedCrossRef
108.
go back to reference Peres MF, Masruha MR, Zukerman E, Moreira-Filho CA, Cavalheiro EA (2006) Potential therapeutic use of melatonin in migraine and other headache disorders. Exp Op Investig Drugs 15:367–375, 1:CAS:528:DC%2BD28XivVOmsb8%3DCrossRef Peres MF, Masruha MR, Zukerman E, Moreira-Filho CA, Cavalheiro EA (2006) Potential therapeutic use of melatonin in migraine and other headache disorders. Exp Op Investig Drugs 15:367–375, 1:CAS:528:DC%2BD28XivVOmsb8%3DCrossRef
109.
go back to reference Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B (2006) The fixed combination of acetylsalicylic acid, paracetamol, and caffeine (reply). Cephalalgia 26:1087–1090 Diener HC, Pfaffenrath V, Pageler L, Peil H, Aicher B (2006) The fixed combination of acetylsalicylic acid, paracetamol, and caffeine (reply). Cephalalgia 26:1087–1090
110.
go back to reference Kellstein DE, Lipton RB, Geetha R, Koronkiewicz K, Evans FT, Stewart WF, Wilkes K, Furey SA, Subramanian T, Cooper SA (2000) Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study. Cephalalgia 20:233–243, 10999673, 1:STN:280:DC%2BD3cvkslWjsw%3D%3DPubMedCrossRef Kellstein DE, Lipton RB, Geetha R, Koronkiewicz K, Evans FT, Stewart WF, Wilkes K, Furey SA, Subramanian T, Cooper SA (2000) Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study. Cephalalgia 20:233–243, 10999673, 1:STN:280:DC%2BD3cvkslWjsw%3D%3DPubMedCrossRef
111.
go back to reference Lipton RB, Baggish S, Stewart WF, Codispoti JR, Fu M (2000) Efficacy and safety of acetaminophen in the treatment of migraine—results of a randomized, double-blind, placebo-controlled, population-based study. Arch Intern Med 160:3486–3492, 11112243, 1:CAS:528:DC%2BD3MXitFSqsw%3D%3DPubMedCrossRef Lipton RB, Baggish S, Stewart WF, Codispoti JR, Fu M (2000) Efficacy and safety of acetaminophen in the treatment of migraine—results of a randomized, double-blind, placebo-controlled, population-based study. Arch Intern Med 160:3486–3492, 11112243, 1:CAS:528:DC%2BD3MXitFSqsw%3D%3DPubMedCrossRef
112.
go back to reference Scher A, Lipton RN, Bigal M (2010) Response to ‘Comments on results of Scher et al. pertaining to nonprescription caffeine-containing combination analgesics’. Cephalalgia 30:1535–1536, 21108517PubMedCrossRef Scher A, Lipton RN, Bigal M (2010) Response to ‘Comments on results of Scher et al. pertaining to nonprescription caffeine-containing combination analgesics’. Cephalalgia 30:1535–1536, 21108517PubMedCrossRef
Metadata
Title
Self-medication of migraine and tension-type headache: summary of the evidence-based recommendations of the Deutsche Migräne und Kopfschmerzgesellschaft (DMKG), the Deutsche Gesellschaft für Neurologie (DGN), the Österreichische Kopfschmerzgesellschaft (ÖKSG) and the Schweizerische Kopfwehgesellschaft (SKG)
Authors
Gunther Haag
Hans-Christoph Diener
Arne May
Christian Meyer
Hartmut Morck
Andreas Straube
Peter Wessely
Stefan Evers
Publication date
01-04-2011
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 2/2011
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-010-0266-4

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