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Clinical and Experimental Nephrology
Published in: Clinical and Experimental Nephrology 1/2012

01-02-2012 | Original Article

Accumulation of visceral fat in maintenance hemodialysis patients

Authors: Takatomi Yurugi, Satoshi Morimoto, Takayuki Okamoto, Yoshifumi Amari, Yuko Kasuno, Masayoshi Fukui, Fumitaka Nakajima, Mitsushige Nishikawa, Toshiji Iwasaka

Published in: Clinical and Experimental Nephrology | Issue 1/2012

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Abstract

Background

In hemodialysis (HD) patients, obesity has been recognized as a serious risk factor for mortality and morbidity for cardiovascular diseases. In addition, abnormalities of lipid profiles exist in these patients.

Methods

In patients undergoing maintenance HD, incidences of abnormality of lipid profiles and visceral obesity determined by computed tomography scans were compared. In addition, the relationship between visceral fat area (VFA) and brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, or carotid intima-media thickness (IMT), an index of atherosis, was examined.

Results

The incidence of high VFA (27.0%) was significantly greater than that of high body mass index (BMI) (9.7%), high low-density-lipoprotein cholesterol (LDL-C) (4.8%), and high triglyceride (12.7%). In patients with diabetes mellitus (DM), waist circumference and VFA showed a significant positive relationship with baPWV. baPWV was significantly higher in patients with high VFA and DM than in patients with low VFA without DM, those with high VFA without DM, and those with low VFA and DM. Carotid IMT was significantly greater in patients with high VFA and DM than in those with low VFA without DM and those with low VFA and DM.

Conclusions

The incidence of high VFA was much greater than that of high BMI, high LDL-C, or high triglyceride. Visceral fat accumulation may be related to both arterial stiffness and atherosis in diabetic patients on maintenance HD.
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Metadata
Title
Accumulation of visceral fat in maintenance hemodialysis patients
Authors
Takatomi Yurugi
Satoshi Morimoto
Takayuki Okamoto
Yoshifumi Amari
Yuko Kasuno
Masayoshi Fukui
Fumitaka Nakajima
Mitsushige Nishikawa
Toshiji Iwasaka
Publication date
01-02-2012
Publisher
Springer Japan
Published in
Clinical and Experimental Nephrology / Issue 1/2012
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-011-0544-8

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