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01-02-2011 | Review Article

Involvement of bone-marrow-derived cells in kidney fibrosis

Authors: Takashi Wada, Norihiko Sakai, Yoshio Sakai, Kouji Matsushima, Shuichi Kaneko, Kengo Furuichi

Published in: Clinical and Experimental Nephrology | Issue 1/2011

Abstract

Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generation of matrix-producing cells in diseased kidneys have been categorized as activated resident stromal cells (e.g., fibroblasts, pericytes), infiltrating bone-marrow-derived cells (e.g., fibrocytes, T cells, macrophages), and cells derived from epithelial–mesenchymal transition/endothelial–mesenchymal transition. Among these cell sources, accumulating evidence has shed light on the involvement of bone-marrow-derived cells, including monocytes/macrophages, and a circulating mesenchymal progenitor cell, fibrocyte, in the progression of fibrosis in kidney. Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin–angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis.

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Title: Involvement of bone-marrow-derived cells in kidney fibrosis
Authors: Takashi Wada
Norihiko Sakai
Yoshio Sakai
Kouji Matsushima
Shuichi Kaneko
Kengo Furuichi
Publication date: 01-02-2011
Publisher: Springer Japan
Published in: Clinical and Experimental Nephrology / Issue 1/2011
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI: https://doi.org/10.1007/s10157-010-0372-2

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