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Published in: Techniques in Coloproctology 6/2019

01-06-2019 | Constipation | Original Article

Sacral nerve stimulation for constipation: long-term outcomes

Authors: S. Gortazar de las Casas, I. Rubio-Pérez, J. Saavedra Ambrosy, A. Sancho de Avila, M. Álvarez-Gallego, J. L. Marijuan Martín, I. Pascual Miguelañez

Published in: Techniques in Coloproctology | Issue 6/2019

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Abstract

Background

There has been some controversy regarding the efficacy of sacral nerve stimulation (SNS) for the treatment of chronic constipation, due to less positive outcomes and concerns about cost-effectiveness in the long term. The aim of the present study was to evaluate the long-term outcomes of SNS in patients with chronic constipation.

Methods

A retrospective study was conducted on patients who had SNS for chronic constipation in 2008–2017 at our institution. Clinical factors, profile of constipation, physiology studies, and patient satisfaction with SNS therapy were investigated during a follow-up period up to 10 years after the implantation.

Results

Twenty-nine patients [86% female, median age 49 years (range 17–86)] were tested for SNS, and 24 received implants after a positive test phase [median 47 days (range 21–56 days)]. There were 27 bilateral and 2 unilateral implants, in S3 or S4 depending on best response. Mean follow-up was 59 months. Efficacy was considered as a score > 5 (on a scale of 1–10) in general symptom improvement. Nine (37.9%) implanted patients had a satisfaction score > 5. In 6 cases (25%), patient satisfaction was higher than 9. Due to the small sample size, there were no statistically significant variables considered as predictors of response.

Conclusions

Our results agree with current studies which describe around a 30% response of SNS for refractory constipation. However, there is a small group of patients highly satisfied with SNS therapy. More studies are needed to better understand this profile and optimize outcomes.
Literature
1.
go back to reference Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: Parte 2: diagnóstico y tratamiento. Gastroenterol. Hepatol. 40:303–316CrossRefPubMed Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: Parte 2: diagnóstico y tratamiento. Gastroenterol. Hepatol. 40:303–316CrossRefPubMed
2.
go back to reference Knowles CH (2017) Constipation. In: Herold A, Lehur PA, Matzel KE, O’Connell PR (eds) Coloproctology, 2nd edn. Springer, Germany, pp 103–120CrossRef Knowles CH (2017) Constipation. In: Herold A, Lehur PA, Matzel KE, O’Connell PR (eds) Coloproctology, 2nd edn. Springer, Germany, pp 103–120CrossRef
4.
go back to reference Carrington EV et al (2014) A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil 26:1222–1237CrossRefPubMed Carrington EV et al (2014) A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation. Neurogastroenterol Motil 26:1222–1237CrossRefPubMed
5.
go back to reference Dinning PG et al (2015) Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study. Am J Gastroenterol 110:733–740CrossRefPubMed Dinning PG et al (2015) Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study. Am J Gastroenterol 110:733–740CrossRefPubMed
6.
go back to reference Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: parte 1: definición, etiología y manifestaciones clínicas. Gastroenterol Hepatol 40:132–141CrossRefPubMed Serra J et al (2017) Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto: parte 1: definición, etiología y manifestaciones clínicas. Gastroenterol Hepatol 40:132–141CrossRefPubMed
7.
go back to reference Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O (2005) Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroenterol 40:540–551CrossRefPubMed Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O (2005) Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroenterol 40:540–551CrossRefPubMed
8.
go back to reference Belsey J, Greenfield S, Candy D, Geraint M (2010) Systematic review: Impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 31:938–949PubMed Belsey J, Greenfield S, Candy D, Geraint M (2010) Systematic review: Impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther 31:938–949PubMed
9.
go back to reference SCM H et al. (2017) Sacral neuromodulation versus personalized conservative treatment in patients with idiopathic slow-transit constipation: study protocol of the No. 2-trial, a multicentre randomized controlled trial. Color. Disease Conference 12th Scientific Annual Meeting European Society of Coloproctology Gastroenterology, pp 493–501. doi: 10.1111/codi.13799 SCM H et al. (2017) Sacral neuromodulation versus personalized conservative treatment in patients with idiopathic slow-transit constipation: study protocol of the No. 2-trial, a multicentre randomized controlled trial. Color. Disease Conference 12th Scientific Annual Meeting European Society of Coloproctology Gastroenterology, pp 493–501. doi: 10.1111/codi.13799
10.
go back to reference Schiano-di-Visconte M et al (2018) Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up. Tech Coloproctol 22:97–105CrossRefPubMed Schiano-di-Visconte M et al (2018) Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up. Tech Coloproctol 22:97–105CrossRefPubMed
11.
go back to reference Thomas GP, Dudding TC, Rahbour G, Nicholls RJ, Vaizey CJ (2013) Sacral nerve stimulation for constipation. Br J Surg 100:174–181CrossRefPubMed Thomas GP, Dudding TC, Rahbour G, Nicholls RJ, Vaizey CJ (2013) Sacral nerve stimulation for constipation. Br J Surg 100:174–181CrossRefPubMed
12.
go back to reference Zeiton M, Faily S, Nicholson J, Telford K, Sharma A (2016) Sacral nerve stimulation—hidden costs (uncovered). Int J Colorectal Dis 31:1005–1010CrossRefPubMed Zeiton M, Faily S, Nicholson J, Telford K, Sharma A (2016) Sacral nerve stimulation—hidden costs (uncovered). Int J Colorectal Dis 31:1005–1010CrossRefPubMed
15.
go back to reference Yang D, He L, Su T-R, Chen Y, Wang Q (2018) Outcomes of laparoscopic subtotal colectomy with cecorectal anastomosis for slow-transit constipation: a single center retrospective study. Acta Chir Belg 119:1–5 Yang D, He L, Su T-R, Chen Y, Wang Q (2018) Outcomes of laparoscopic subtotal colectomy with cecorectal anastomosis for slow-transit constipation: a single center retrospective study. Acta Chir Belg 119:1–5
16.
go back to reference Lumi CM et al (2016) Neuromodulación sacra: resultados a largo plazo. Acta Gastroenterol Latinoam 46:82–94PubMed Lumi CM et al (2016) Neuromodulación sacra: resultados a largo plazo. Acta Gastroenterol Latinoam 46:82–94PubMed
17.
go back to reference Pilkington SA et al (2017) Surgery for constipation: systematic review and practice recommendations: Results V: sacral Nerve stimulation. Color Dis 19:92–100CrossRef Pilkington SA et al (2017) Surgery for constipation: systematic review and practice recommendations: Results V: sacral Nerve stimulation. Color Dis 19:92–100CrossRef
18.
go back to reference Xin HW et al (2014) Diagnosis of functional constipation: agreement between Rome III and Rome II criteria and evaluation for the practicality. J Dig Dis 15:314–320CrossRefPubMedPubMedCentral Xin HW et al (2014) Diagnosis of functional constipation: agreement between Rome III and Rome II criteria and evaluation for the practicality. J Dig Dis 15:314–320CrossRefPubMedPubMedCentral
19.
go back to reference Ley Orgánica 2/2006, de 3 de mayo, de Educación. BOE 22-06-2007, núm. 149, pág. 27049. Ley Orgánica 2/2006, de 3 de mayo, de Educación. BOE 22-06-2007, núm. 149, pág. 27049.
20.
go back to reference Zerbib F et al (2017) Randomized clinical trial of sacral nerve stimulation for refractory constipation. Br J Surg 104:205–213CrossRefPubMed Zerbib F et al (2017) Randomized clinical trial of sacral nerve stimulation for refractory constipation. Br J Surg 104:205–213CrossRefPubMed
21.
go back to reference Patton V, Stewart P, Lubowski DZ, Cook IJ, Dinning PG (2016) Sacral nerve stimulation fails to offer long-term benefit in patients with slow-transit constipation. Dis Colon Rectum 59:878–885CrossRefPubMed Patton V, Stewart P, Lubowski DZ, Cook IJ, Dinning PG (2016) Sacral nerve stimulation fails to offer long-term benefit in patients with slow-transit constipation. Dis Colon Rectum 59:878–885CrossRefPubMed
22.
go back to reference Knowles CH, Thin N, Gill K, Bhan C (2012) Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Ann Surg 255(4):643–649CrossRefPubMed Knowles CH, Thin N, Gill K, Bhan C (2012) Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Ann Surg 255(4):643–649CrossRefPubMed
23.
24.
go back to reference Carriero A, Martelluci J, Talenento P, Ferrari CA (2010) Sacral nerve stimulation for constipation: do we still miss something? Int J Colorectal Dis 25:1005–1010CrossRefPubMed Carriero A, Martelluci J, Talenento P, Ferrari CA (2010) Sacral nerve stimulation for constipation: do we still miss something? Int J Colorectal Dis 25:1005–1010CrossRefPubMed
25.
go back to reference Maeda Y, Matzel K, Lundby L, Buntzen S, Laurberg S (2011) Postoperative issues of sacral nerve stimulation for fecal incontinence and constipation: a systematic literature review and treatment guideline. Dis Colon Rectum 54:1443–1460CrossRefPubMed Maeda Y, Matzel K, Lundby L, Buntzen S, Laurberg S (2011) Postoperative issues of sacral nerve stimulation for fecal incontinence and constipation: a systematic literature review and treatment guideline. Dis Colon Rectum 54:1443–1460CrossRefPubMed
26.
go back to reference Maeda Y et al (2015) Sacral nerve stimulation for faecal incontinence and constipation: a European consensus statement. Color Dis 17:O74–O87CrossRef Maeda Y et al (2015) Sacral nerve stimulation for faecal incontinence and constipation: a European consensus statement. Color Dis 17:O74–O87CrossRef
Metadata
Title
Sacral nerve stimulation for constipation: long-term outcomes
Authors
S. Gortazar de las Casas
I. Rubio-Pérez
J. Saavedra Ambrosy
A. Sancho de Avila
M. Álvarez-Gallego
J. L. Marijuan Martín
I. Pascual Miguelañez
Publication date
01-06-2019
Publisher
Springer International Publishing
Published in
Techniques in Coloproctology / Issue 6/2019
Print ISSN: 1123-6337
Electronic ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-019-02011-z

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