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Gastric Cancer
Published in: Gastric Cancer 4/2017

01-07-2017 | Review Article

Sarcopenia in gastric cancer: when the loss costs too much

Authors: Elena Ongaro, Vanessa Buoro, Marika Cinausero, Riccardo Caccialanza, Annalisa Turri, Valentina Fanotto, Debora Basile, Maria Grazia Vitale, Paola Ermacora, Giovanni Gerardo Cardellino, Laura Nicoletti, Lorenzo Fornaro, Andrea Casadei-Gardini, Giuseppe Aprile

Published in: Gastric Cancer | Issue 4/2017

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Abstract

Sarcopenia is a complex syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Malignancy is a major determinant of sarcopenia, and gastric cancer (GC) is among the most common causes of this phenomenon. As sarcopenia is a well-recognized poor prognostic feature in GC and has been associated with worse tolerance of surgical and medical treatments, members of the multidisciplinary team should be aware of the clinical relevance, pathogenic mechanisms, and potential treatments for this syndrome. The importance of sarcopenia is often underestimated in everyday practice and clinical trials, particularly among elderly or fragile patients. As treatment options are improving in all disease stages, deeper knowledge and greater attention to the metabolic balance in GC patients could further increase the benefit of novel therapeutic strategies and dramatically impact on quality of life. In this review, we describe the role of sarcopenia in different phases of GC progression. Our aim is to provide oncologists and surgeons dealing with GC patients with a useful tool for comprehensive assessment and timely management of this potentially life-threatening condition.
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Metadata
Title
Sarcopenia in gastric cancer: when the loss costs too much
Authors
Elena Ongaro
Vanessa Buoro
Marika Cinausero
Riccardo Caccialanza
Annalisa Turri
Valentina Fanotto
Debora Basile
Maria Grazia Vitale
Paola Ermacora
Giovanni Gerardo Cardellino
Laura Nicoletti
Lorenzo Fornaro
Andrea Casadei-Gardini
Giuseppe Aprile
Publication date
01-07-2017
Publisher
Springer Japan
Published in
Gastric Cancer / Issue 4/2017
Print ISSN: 1436-3291
Electronic ISSN: 1436-3305
DOI
https://doi.org/10.1007/s10120-017-0722-9

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
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