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24-06-2022 | Craniomandibular Dysfunction and Stress | Original Article

Simultaneous red and infrared light-emitting diodes reduced pain in individuals with temporomandibular disorder: a randomized, controlled, double-blind, clinical trial

Authors: Dowglas Fernando Magalhães de Sousa, Tainá Caroline dos Santos Malavazzi, Alessandro Melo Deana, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari

Published in: Lasers in Medical Science | Issue 9/2022

Abstract

The aim of the present study was to evaluate the effects of photobiomodulation (PBM) with the simultaneous use of red and infrared LEDs on pain and mandibular range of motion in individuals with temporomandibular disorder (TMD). Eighteen participants were randomly allocated to an LED group or control group. The device had 18 red LEDs (660 nm) and 18 infrared LEDs (850 nm), with a total power irradiated of 126 mW and 75.6 J per point. The device was placed in the regions of the temporomandibular joint (TMJ) and masticatory muscles once per day three times per week for 2 weeks. Pain intensity was measured using the visual analog scale (VAS). Mandibular range of motion was determined using digital calipers and considering different conditions (unassisted opening without pain, maximum opening with and without assistance, right and left lateral movements, and protrusion). Evaluations were performed before treatment, immediately after the first LED irradiation session and at the end of six sessions. A significant reduction in pain intensity was found in the LED group at the end of treatment compared to the control group (p < 0.001) as well as in the comparison between the pretreatment and end of treatment evaluations (p < 0.001). Regarding mandibular movements, no statistically significant differences between the LED group and control group were found at the end of treatment for any of the conditions analyzed or in the comparison between the beginning and end of treatment with LED. Photobiomodulation using a cluster with red and infrared LEDs induced a reduction in pain in individuals with temporomandibular disorder but did not alter mandibular range of motion in these individuals. Trial registration number: NCT03696706; retrospectively registered (ClinicalTrials.gov).

Chen J, Huang Z, Ge M, Gao M (2015) Efficacy of low-level laser therapy in the treatment of TMDs: a meta-analysis of 14 randomised controlled trials. J Oral Rehabil 42:291–299CrossRefPubMed

Aisaiti A, Zhou Y, Wen Y, Zhou W, Wang C, Zhao J, Yu L, Zhang J, Wang K, Svensson P (2021) Effect of photobiomodulation therapy on painful temporomandibular disorders. Sci Rep 11:9049. https://doi.org/10.1038/s41598-021-87265-0CrossRefPubMedPubMedCentral

Sobral APT, de Sobral SS, Campos TM, Horliana ACRT, Fernandes KPS, Bussadori SK, Motta LJ (2021) Photobiomodulation and myofascial temporomandibular disorder: systematic review and meta-analysis followed by cost-effectiveness analysis. J Clin Exp Dent 13:e724–e732. https://doi.org/10.4317/jced.58084CrossRefPubMedPubMedCentral

Freire AB, de Nardi AT, Boufleur J, Chiodelli L, Pasinato F, Corrêa ECR (2014) Multimodal physiotherapeutic approach: effects on the temporomandibular disorder diagnosis and severity. Fisioterapia em Movimento 27:219–227. https://doi.org/10.1590/0103-5150.027.002.ao07CrossRef

Khalighi HR, Mortazavi H, Mojahedi SM, Azari-Marhabi S, Abbasabadi FM (2016) Low level laser therapy versus pharmacotherapy in improving myofascial pain disorder syndrome. J Lasers Med Sci 7:45–50. https://doi.org/10.15171/jlms.2016.10

de Carli BMG, Magro AKD, Souza-Silva BN, de Matos F, S, de Carli JP, Paranhos LR, Magro ED, (2016) The effect of laser and botulinum toxin in the treatment of myofascial pain and mouth opening: a randomized clinical trial. J Photochem Photobiol, B 159:120–123. https://doi.org/10.1016/j.jphotobiol.2016.03.038CrossRefPubMed

Carvalho Bortoletto C, Cordeiro Da Silva F, Fernanda Da Costa Silva P, Haddad Leal De Godoy C, Agnelli Mesquita-Ferrari R, Porta K, Fernandes S, Romano R, Bussadori SK (2014) Evaluation of cranio-cervical posture in children with bruxism before and after bite plate therapy: a pilot project. J Phys Ther Sci 26:1125–1128. https://doi.org/10.1589/jpts.26.1125

Gomes NCMC, Berni-Schwarzenbeck KCS, Packer AC, Rdrigues-Bigaton D (2012) Efeito da estimulação elétrica de alta voltagem catódica sobre a dor em mulheres com DTM. Braz J Phys Ther 16:10–15. https://doi.org/10.1590/S1413-35552012000100003CrossRef

el Hage Y, Politti F, Magalhães de Sousa DF, Marciela Herpich C, dos Santos Phillip, Gloria I, Fidelis André, de Paula Gomes C, Paula Amaral A, Cristina de Melo N, Correa da Silva T, Edmur Camargo Arruda E, Ferreira Amorim C, Caroline Gadotti I, Oliveira Gonzalez T, Berzin F, Kalil Bussadori S, Barbosa Santos Garcia M, Roberto Borges Barbosa B, Aparecida Biasotto-Gonzalez D (2013) Effect of mandibular mobilization on electromyographic signals in muscles of mastication and static balance in individuals with temporomandibular disorder: study protocol for a randomized controlled trial. Trials 14:316. https://doi.org/10.1186/1745-6215-14-316CrossRefPubMedPubMedCentral

10.

Amaral AP, Politti F, Hage YE, Arruda EEC, Amorin CF, Biasotto-Gonzalez DA (2013) Immediate effect of nonspecific mandibular mobilization on postural control in subjects with temporomandibular disorder: a single-blind, randomized, controlled clinical trial. Braz J Phys Ther 17:121–127. https://doi.org/10.1590/S1413-35552012005000075CrossRefPubMed

11.

da Silva MM, Albertini R, de Tarso Camillo de Carvalho P, Leal-Junior ECP, Bussadori SK, Vieira SS, Bocalini DS, de Oliveira LVF, Grandinetti V, Silva JA, Serra AJ (2018) Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers Med Sci 33:343-351https://doi.org/10.1007/s10103-017-2388-2

12.

Manfredini D, Cocilovo F, Favero L, Ferronato G, Tonello S, GUARDA-NARDINI L, (2011) Surface electromyography of jaw muscles and kinesiographic recordings: diagnostic accuracy for myofascial pain. J Oral Rehabil 38:791–799. https://doi.org/10.1111/j.1365-2842.2011.02218.xCrossRefPubMed

13.

Seifi M, Ebadifar A, Kabiri S, Badiee MR, Abdolazimi Z, Amdjadi P (2017) Comparative effectiveness of low level laser therapy and transcutaneous electric nerve stimulation on temporomandibular joint disorders. Journal of Lasers in Medical Sciences 8:S27–S31. https://doi.org/10.15171/jlms.2017.s6

14.

Herpich CM, Leal-Junior ECP, Gomes CAF de P, Gloria IP dos S, Amaral AP, Amaral M de F de RS, Politti F, Biasotto-Gonzalez DA (2018) Immediate and short-term effects of phototherapy on pain, muscle activity, and joint mobility in women with temporomandibular disorder: a randomized, double-blind, placebo-controlled, clinical trial. Disabil Rehabil 40:2318-2324https://doi.org/10.1080/09638288.2017.1336648

15.

Al-Quisi AF, Al-Anee AM, AL-jumaily HA, Bahr EF, Finjan DA, (2019) Efficacy of the LED red light therapy in the treatment of temporomandibular disorders: double blind randomized controlled trial. Pain Res Treat 2019:1–5. https://doi.org/10.1155/2019/8578703CrossRef

16.

Leal de Godoy CH, Motta LJ, Santos Fernandes KP, Mesquita-Ferrari RA, Deana AM, Bussadori SK (2015) Effect of low-level laser therapy on adolescents with temporomandibular disorder: a blind randomized controlled pilot study. J Oral Maxillofac Surg 73:622–629. https://doi.org/10.1016/j.joms.2014.09.018CrossRefPubMed

17.

Costa DR, Costa DR, Pessoa DR, Masulo LJ, Arisawa EÂLS, Nicolau RA (2017) Efeito da terapia LED na disfunção temporomandibular: estudo de caso. Scientia Medica 27:25872. https://doi.org/10.15448/1980-6108.2017.2.25872

18.

Shobha R, Narayanan V, Jagadish Pai B, Jaishankar H, Jijin M (2017) Low-level laser therapy: a novel therapeutic approach to temporomandibular disorder – a randomized, double-blinded, placebo-controlled trial. Indian J Dent Res 28:380. https://doi.org/10.4103/ijdr.IJDR_345_15CrossRefPubMed

19.

Marini I, Gatto MR, Bonetti GA (2010) Effects of superpulsed low-level laser therapy on temporomandibular joint pain. Clin J Pain 26:611–616. https://doi.org/10.1097/AJP.0b013e3181e0190dCrossRefPubMed

20.

Borges RMM, Cardoso DS, Flores BC, da Luz RD, Machado CR, Cerveira GP, Daitx RB, Dohnert MB (2018) Effects of different photobiomodulation dosimetries on temporomandibular dysfunction: a randomized, double-blind, placebo-controlled clinical trial. Lasers Med Sci 33:1859–1866. https://doi.org/10.1007/s10103-018-2533-6CrossRefPubMed

21.

Magri LV, Carvalho VA, Rodrigues FCC, Bataglion C, Leite-Panissi CRA (2018) Non-specific effects and clusters of women with painful TMD responders and non-responders to LLLT: double-blind randomized clinical trial. Lasers Med Sci 33:385–392. https://doi.org/10.1007/s10103-017-2406-4CrossRefPubMed

22.

Basili M (2017) Low-level laser therapy in the treatment of muscle-skelet pain in patients affected by temporomandibular disorders. Oral & Implantology 10:406. https://doi.org/10.11138/orl/2017.10.4.406

23.

Dostalová T, Hlinakova P, Kasparova M, Rehacek A, Vavrickova L, Navrátil L (2012) Effectiveness of physiotherapy and GaAlAs laser in the management of temporomandibular joint disorders. Photomed Laser Surg 30:275–280. https://doi.org/10.1089/pho.2011.3171CrossRefPubMedPubMedCentral

24.

Langella LG, Silva PFC, Costa-Santos L, Gonçalves MLL, Motta LJ, Deana AM, Fernandes KPS, Mesquita-Ferrari RA, Bussadori SK (2018) Photobiomodulation versus light-emitting diode (LED) therapy in the treatment of temporomandibular disorder: study protocol for a randomized, controlled clinical trial. Trials 19:71. https://doi.org/10.1186/s13063-018-2444-7CrossRefPubMedPubMedCentral

25.

Yeh NG, Wu C-H, Cheng TC (2010) Light-emitting diodes—their potential in biomedical applications. Renew Sustain Energy Rev 14:2161–2166. https://doi.org/10.1016/j.rser.2010.02.015CrossRef

26.

Kelencz CA, Muñoz ISS, Amorim CF, Nicolau RA (2010) Effect of low-power gallium–aluminum–arsenium noncoherent light (640 nm) on muscle activity: a clinical study. Photomed Laser Surg 28:647–652. https://doi.org/10.1089/pho.2008.2467CrossRefPubMed

27.

Muñoz-Cánoves P, Scheele C, Pedersen BK, Serrano AL (2013) Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword? FEBS J 280:4131–4148. https://doi.org/10.1111/febs.12338CrossRefPubMedPubMedCentral

28.

de Castro IC v., Rosa CB, Carvalho CM, Aragão JS, Cangussu MCT, dos Santos JN, Pinheiro ALB (2015)Assessment of different energy delivery settings in laser and LED phototherapies in the inflammatory process of rat’s TMJ induced by carrageenan. Lasers Med Sci 30:2105-2113https://doi.org/10.1007/s10103-015-1748-z

29.

Panhoca VH, de Fatima Zanirato Lizarelli R, Nunez SC, Pizzo RC de A, Grecco C, Paolillo FR, Bagnato VS (2015)Comparative clinical study of light analgesic effect on temporomandibular disorder (TMD) using red and infrared led therapy. Lasers Med Sci 30:815-822https://doi.org/10.1007/s10103-013-1444-9

30.

Bashkatov AN, Genina EA, Kochubey VI, Tuchin VV (2005) Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm. J Phys D Appl Phys 38:2543–2555. https://doi.org/10.1088/0022-3727/38/15/004CrossRef

31.

de Sousa DFM, Gonçalves MLL, Politti F, Lovisetto RDDP, Fernandes KPS, Bussadori SK, Mesquita-Ferrari RA (2019) Photobiomodulation with simultaneous use of red and infrared light emitting diodes in the treatment of temporomandibular disorder: study protocol for a randomized, controlled and double-blind clinical trial. Medicine (United States) 98:e14391. https://doi.org/10.1097/MD.0000000000014391

32.

Suresh K, Chandrashekara S (2012) Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci 5:7. https://doi.org/10.4103/0974-1208.97779CrossRefPubMedPubMedCentral

33.

Dworkin SF, LeResche L (1992) Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord 6:301–355PubMed

34.

de Lucena LBS, Kosminsky M, da Costa LJ, de Góes PSA (2006) Validation of the Portuguese version of the RDC/TMD Axis II questionnaire. Braz Oral Res 20:312–317. https://doi.org/10.1590/S1806-83242006000400006CrossRefPubMed

35.

Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet J-P, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A, Brooks SL, Ceusters W, Drangsholt M, Ettlin D, Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF (2014) Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†. J Oral Facial Pain Headache 28:6–27. https://doi.org/10.11607/jop.1151

36.

Ferreira-Valente MA, Pais-Ribeiro JL, Jensen MP (2011) Validity of four pain intensity rating scales. Pain 152:2399–2404. https://doi.org/10.1016/j.pain.2011.07.005CrossRefPubMed

37.

Costa DR, Pessoa DR, Seefeldt VB, Costa DR, Maia DTL, dos Santos MT, Mota BBM, Delpasso CA, Ribeiro CAD, Nicolau RA (2021) Orofacial evaluation of individuals with temporomandibular disorder after LED therapy associated or not of occlusal splint: a randomized double-blind controlled clinical study. Lasers Med Sci 36:1681–1689. https://doi.org/10.1007/s10103-021-03269-2CrossRefPubMed

38.

Souza NHC, Mesquita-Ferrari RA, Rodrigues MFSD, da Silva DFT, Ribeiro BG, Alves AN, Garcia MP, Nunes FD, da Silva Junior EM, França CM, Bussadori SK, Fernandes KPS (2018) Photobiomodulation and different macrophages phenotypes during muscle tissue repair. J Cell Mol Med 22:4922–4934. https://doi.org/10.1111/jcmm.13757CrossRefPubMedPubMedCentral

39.

Lopez TCC, Malavazzi TC dos S, Rodrigues MFSD, Bach EE, Silva DT, Hi EMB, França CM, Bussadori SK, Mesquita-Ferrari RA, Fernandes KPS (2022) Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury. J Biophotonics 15:e202100271. https://doi.org/10.1002/jbio.202100271

40.

Leal Junior ECP, Lopes-Martins RÁB, de Almeida P, Ramos L, Iversen V, v., Bjordal JM, (2010) Effect of low-level laser therapy (GaAs 904 nm) in skeletal muscle fatigue and biochemical markers of muscle damage in rats. Eur J Appl Physiol 108:1083–1088. https://doi.org/10.1007/s00421-009-1321-1CrossRefPubMed

41.

de Marchi T, Leal-Junior ECP, Lando KC, Cimadon F, Vanin AA, da Rosa DP, Salvador M (2019) Photobiomodulation therapy before futsal matches improves the staying time of athletes in the court and accelerates post-exercise recovery. Lasers Med Sci 34:139–148. https://doi.org/10.1007/s10103-018-2643-1CrossRefPubMed

42.

Baroni BM, Leal Junior ECP, de Marchi T, Lopes AL, Salvador M, Vaz MA (2010) Low level laser therapy before eccentric exercise reduces muscle damage markers in humans. Eur J Appl Physiol 110:789–796. https://doi.org/10.1007/s00421-010-1562-zCrossRefPubMed

Title: Simultaneous red and infrared light-emitting diodes reduced pain in individuals with temporomandibular disorder: a randomized, controlled, double-blind, clinical trial
Authors: Dowglas Fernando Magalhães de Sousa
Tainá Caroline dos Santos Malavazzi
Alessandro Melo Deana
Anna Carolina Ratto Tempestini Horliana
Kristianne Porta Santos Fernandes
Sandra Kalil Bussadori
Raquel Agnelli Mesquita-Ferrari
Publication date: 24-06-2022
Publisher: Springer London
Keyword: Craniomandibular Dysfunction and Stress
Published in: Lasers in Medical Science / Issue 9/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-022-03600-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Simultaneous red and infrared light-emitting diodes reduced pain in individuals with temporomandibular disorder: a randomized, controlled, double-blind, clinical trial

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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