Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 6/2021

01-08-2021 | Chronic Kidney Disease | Original Article

Effects of photobiomodulation in salivary glands of chronic kidney disease patients on hemodialysis

Authors: Vanessa Christina Santos Pavesi, Manoela Domingues Martins, Fábio Luiz Coracin, Aline Silva Sousa, Benedito Jorge Pereira, Renato Araújo Prates, Juliana Freitas da Silva, Marcela Leticia Leal Gonçalves, Cicero Dayves Silva Bezerra, Sandra Kalil Bussadori, Maria Lucia Zarvos Varellis, Alessandro Melo Deana

Published in: Lasers in Medical Science | Issue 6/2021

Login to get access

Abstract

This randomized placebo-controlled trial evaluates the impact of photobiomodulation (PBMT) on the salivary flow and biochemistry of patients with chronic kidney disease (CKD) on hemodialysis. Forty-four patients on hemodialysis self-responded two questionnaires for oral health and salivary gland function perception. The subjects were evaluated for function of salivary glands and randomly allocated to two groups: PBMT group (three irradiations at 808 nm, 100 mW, 142 J/cm2, and 4 J per site); and placebo group. Patients were submitted to non-stimulated and stimulated sialometry and after the treatment at baseline and 14 days. Salivary volume and biochemical of the saliva were analyzed. At baseline, most subjects had self-perception of poor oral health (52.6%) and salivary dysfunction (63.1%). Clinical exam revealed that 47.3% of subjects presented dry mucosa. PBMT promoted increase of the non-stimulated (p = 0.027) and stimulated saliva (p = 0.014) and decrease of urea levels in both non-stimulated (p = 0.0001) and stimulated saliva (p = 0.0001). No alteration was detected in total proteins and calcium analysis. Patients with kidney disease can present alteration in flow, concentrations, and composition of saliva, affecting oral health, but our findings suggest that PBMT is effective to improve hyposalivation and urea levels in saliva of patients with CKD.
Literature
1.
Grassmann A, Gioberge S, Moeller S, Brown G (2005) ESRD patients in 2004: global overview of patient numbers, treatment modalities and associated trends. 20:2587–2593
2.
Long B, Koyfman A, Lee CM (2017) Emergency medicine evaluation and management of the end stage renal disease patient. 35:1946–1955
3.
Cherchiglia ML, Machado EL, Szuster DAC, Andrade ELG, Acúrcio FDA, Caiaffa WT et al (2010) Epidemiological profi le of patients on renal replacement therapy in Brazil, 2000-2004. 44(4):1–10
4.
Sampaio RMM, Coelho MO, Pinto FJM, Osteme EPR (2011) Epidemiological profile of patients with nephropathy and the difficulties in access to treatment. 26(1):95–101
5.
Silva AT, Soares LB, Magajewski FRL (2016) Epidemiologic and economic aspects related to hemodialysis and kidney transplantation in Santa Catarina in the period of 2012-2013. 48:2284–2288
6.
Khanum N, Mysore-Shivalingu M, Basappa S, Patil A, Kanwar S (2017) Evaluation of changes in salivary composition in renal failure patients before and after hemodialysis. 9(11):1340–1345
7.
Inker LA, Astor BC, Fox CH, Tamara I, Lash JP et al (2014) KDOQI US Commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD. 63(5):713–735
8.
Kho H-S, Lee S-W, Chung S-C, Kim Y-K (1999) Oral manifestations and salivary flow rate, pH, and buffer capacity in patients with end-stage renal disease undergoing hemodialysis. 88(3):316–319
9.
García ER, Padilla AM, Camacho MEI, Ramírez MAB (2005) Lesiones bucales en un grupo de pacientes con trasplante renal Oral lesions in a group of kidney transplant patients. 10(3):196–204
10.
García ER, Padilla AM, Romo SA, Ramírez MAB (2006) Oral mucosa symptoms, signs and lesions, in end stage renal disease and non-end stage renal disease diabetic patients. 11(6):467–473
11.
Martins C, Siqueira WL, Oliveira E, Nicolau J, Primo LG (2012) Dental calculus formation in children and adolescents undergoing hemodialysis. 27:1961–1966
12.
Andrade MRTC, Salazar SLA, de Sá LFR, Portela M, Pereira AF, Soares RMA et al (2015) Role of saliva in the caries experience and calculus formation of young patients undergoing hemodialysis. 19(8):1973–1980
13.
Anuradha BR, Katta S, Kode VS, Praveena C, Sathe N, Sandeep N et al (2015) Oral and salivary changes in patients with chronic kidney disease: a clinical and biochemical study. 19(3):297–301
14.
Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi OA, Sanusi AA (2015) Oral findings in chronic kidney disease: implications for management in developing countries. 15(24):2–8
15.
Dioguardi M, Caloro GA, Troiano G, Giannatempo G, Laino L, Petruzzi M et al (2015) Oral manifestations in chronic uremia patients. 38(1):1–6
16.
Honarmand M, Farhad-Mollashahi L, Nakhaee A, Sargolzaie F (2017) Oral manifestation and salivary changes in renal patients undergoing hemodialysis. 9(2):207–210
17.
Venkatapathy R, Govindarajan V, Oza N, Parameswaran S, Dhanasekaran BP, Prashad KV (2014) Salivary creatinine estimation as an alternative to serum creatinine in chronic kidney disease patients. 2014:1–6
18.
Seethalakshmi C, KoteeSwaran D, ChiranjeeVi V (2014) Correlation of serum and salivary biochemical parameters in end stage renal disease patients undergoing hemodialysis in pre and post-dialysis state. 8(12):12–14
19.
Pandya D, Nagrajappa AK, Ravi KS (2016) Assessment and correlation of urea and creatinine levels in saliva and serum of patients with chronic kidney disease, diabetes and hypertension– a research Study. 10(10):58–62
20.
Raimann JG, Calice-Silva V, Thijssen S, Nerbass FB, Vieira MA, Dabel P et al (2016) Saliva urea nitrogen continuously reflects blood urea nitrogen after acute kidney injury diagnosis and management: longitudinal observational data from a collaborative, international, prospective, multicenter study. 42:64–72
21.
Lasisi TJ, Raji YR, Salako BL (2016) Salivary creatinine and urea analysis in patients with chronic kidney disease: a case control study. 17(10):2–6
22.
Renda R (2017) Can salivary creatinine and urea levels be used to diagnose chronic kidney disease in children as accurately as serum creatinine and urea levels? A case–control study. 39(1):452–457
23.
Bots CP, Brand HS, Veerman ECI, Korevaar JC, Valentijn-Benz M, Bezemer PD et al (2005b) Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis. 20(3):578–584
24.
Bots CP, Brand HS, Veerman ECI, Valentijn-Benz M, Amerongen BMV, Amerongen AVN et al (2005a) The management of xerostomia in patients on haemodialysis: comparison of artificial saliva and chewing gum. 19:202–207
25.
Palma LF, Gonnelli FAS, Marcucci M, Dias RS, Giordani AJ, Segreto RA et al (2017) Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. 32(4):827–832
26.
Cafaro A, Arduíno PG, Gambino A, Romagnoli E, Broccoletti R (2014) Effect of laser acupuncture on salivary flow rate in patients with Sjögren’s syndrome. 30(6):1805–1809
27.
Fidelix T, Czapkowski A, Azjen S, Andriolo A, Neto PH, Trevisani V (2017) Low-level laser therapy for xerostomia in primary Sjögren’s syndrome: a randomized trial. 37(3):729–736
28.
Mercadante V, Hamad AA, Lodi G, Porter S, Fedele S (2017) Interventions for the managemente of radiotherapy-induced xerostomia and hyposalivation: a systematic review and meta-analysis. 66:64–74
29.
Loncar B, Stipetic MM, Baricevic M, Risovic D (2011) The effect of low-level laser therapy on salivary glands in patients with xerostomia. 29(3):171–175
30.
Yu C, Tsai Y-F, Fang J-T, Yeh M-M, Fang J-Y, Liu C-Y (2016) Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: a randomized controlled study. 63:9–17
31.
Duruk N, Eser Í (2016) The null effect of chewing gum during hemodialysis on dry mouth. 12-13
32.
Freitas FL, Hambling MR (2016) Proposed mechanisms of photobiomodulation or low-level light therapy. 22(3):7000417
33.
Anders JJ, Lanzafame RJ, Arany PR (2015) Low-level light/laser therapy versus photobiomodulation therapy. 33(4):183–184
34.
Epstein SR, Mandel I, Scoppi IW (1980) Salivary composition and calculus formation in patients undergoing hemodialysis. 51(6):336–338
35.
Kaushik A, Reddy SS, Umesh L, Devi BKY, Santana N, Rakesh N (2013) Oral and salivary changes among renal patients undergoing hemodialysis: a cross-sectional study. 23(2):125–129
36.
Simões A, Nicolau J, de Souza DN, Ferreira LS, de Paula Eduardo C, Apel C et al (2007) Effect of defocused infrared diode laser on salivary flow rate and some salivary parameters of rats. 12:25–30
37.
de Jesus VC, Beanes G, Paraguassú GM, Ramalho LMP, Pinheiro ALB, Ramalho MJP et al (2015) Influence of laser photobiomodulation (GaAlAs) on salivary flow rate and histomorphometry of the submandibular glands of hypothyroid rats. 30(4):1275–1280
38.
Gonnelli FAS, Palma LF, Giordani AJ, Deboni ALS, Dias RS, Segreto RA et al (2016) Low-level laser for mitigation of low salivary flow rate in head and neck cancer patients undergoing radiochemotherapy: a prospective longitudinal study. Photomed Laser Surg:326–330
39.
Carvalho C, Manso AC, Escoval A, Salvado F, Nunes C (2013) Geriatric Oral Health Assessment Index (GOHAI). 31(2):153–159
40.
Martins C, Siqueira WL, Primo LSSG (2008) Oral and salivary flow characteristics of a group of Brazilian children and adolescents with chronic renal failure. 23(4):619–624
41.
Villa A, Wolff A, Narayana N, Dawes C, Aframian DJ, Pedersen AML et al (2016) World workshop on oral medicine VI: a systematic review of medication-induced salivary gland dysfunction. 22:365–382
42.
Proctor GB (2016) The physiology of salivary secretion. 2000 70:11-25
43.
De-Nour K, Czaczkes JW (1980) A saliva substitute as a tool in decreasing over drinking in dialysis patients. 16(1):43–44
44.
Simões A, Platero MD, Campos L, Aranha AC, de Paula Eduardo C, Nicolau J (2009) Laser as a therapy for dry mouth symptoms in a patient with Sjögren's syndrome: a case report. 29(3):134–137
45.
Cowen D, Tardieu C, Schubert M, Peterson D, Resbeut M, Faucher C et al (1997) Low energy helium-neon laser in the prevention of oral mucositis in patients undergoing bone marrow transplant: results of a double blind randomized trial. 38(4):697–703
46.
de Oliveira Lopes C, Mas JRI, Zângaro RA (2006) Low level laser therapy in the prevention of radiotherapy-induced xerostomia and oral mucositis. 39(2):131–136
47.
Oton-Leite AF, Elias LSA, Morais MO, Pinezi JCD, Leles CR, Silva MAGS et al (2013) Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy. 294-300
48.
Carramolino-Cuéllar E, Lauritano D, Silvestre F-J, Carinci F, Lucchese A, Silvestre-Rangil J (2018) Salivary flow and xerostomia in patients with type 2 diabetes. 47(5):526–530
49.
Pavlic V (2012) The effects of low-level laser therapy on xerostomia (mouth dryness). 5(6):247–250
50.
Hamblin MR (2017) Mechanisms and mitochondrial redox signaling in photobiomodulation. 94:199–212
51.
Hamblin MR (2017) Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. 4(3):337–361
52.
Migliario M, Sabbatini M, Mortellaro C, Renò F (2018) Near infrared low level laser therapy and cell proliferation: the emerging role of redox sensitive signal transduction pathways
53.
Saleh J, Figueiredo MAZ, Cherubini K, Braga-Filho A, Salum FG (2014) Effect of low-level laser therapy on radiotherapy induced hyposalivation and xerostomia: a pilot study. 32(10):546–552
54.
Spanemberg JC, Figueiredo MA, Cherubini K, Salum FG (2016) Low-level laser therapy: a review of its applications in the management of oral mucosal disorders. 22(6):24–31
55.
Pandeshwar P, Roa MD, Das R, Shastry SP, Kaul R, Srinivasreddy MB (2015) Photobiomodulation in oral medicine: a review. 1-12
Metadata
Title
Effects of photobiomodulation in salivary glands of chronic kidney disease patients on hemodialysis
Authors
Vanessa Christina Santos Pavesi
Manoela Domingues Martins
Fábio Luiz Coracin
Aline Silva Sousa
Benedito Jorge Pereira
Renato Araújo Prates
Juliana Freitas da Silva
Marcela Leticia Leal Gonçalves
Cicero Dayves Silva Bezerra
Sandra Kalil Bussadori
Maria Lucia Zarvos Varellis
Alessandro Melo Deana
Publication date
01-08-2021
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 6/2021
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-020-03158-0

Other articles of this Issue 6/2021

Lasers in Medical Science 6/2021 Go to the issue

Original Article

Evaluation of gingival displacement methods in terms of periodontal health at crown restorations produced by digital scan: 1-year clinical follow-up

Original Article

Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis

Original Article

The effect of combined curcumin-mediated photodynamic therapy and artificial skin on Staphylococcus aureus–infected wounds in rats

Original Article

Efficacy and safety of 1440-nm Nd:YAG laser on lower face and neck rejuvenation

Review Article

Photobiomodulation: systematic review and meta-analysis of the most used parameters in the resolution diabetic foot ulcers

Original Article

Carbon dioxide (CO2) laser ablation of symptomatic vaginal endometriosis: a pilot study