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01-10-2019 | Photodynamic Therapy | Review Article

Photodynamic antimicrobial chemotherapy has an overt killing effect on periodontal pathogens? A systematic review of experimental studies

Authors: Daniele Peron, Alexandre Bergamo, Renato Prates, Stella Sousa Vieira, Paulo de Tarso Camillo de Carvalho, Andrey Jorge Serra

Published in: Lasers in Medical Science | Issue 8/2019

Abstract

The periodontal disease (PD) etiology is mainly associated with some bacterial strains, such as Porphyromonas gingivalis (P. gingivalis). Nonsurgical root scaling (e.g., antibiotics) may achieve a temporary decrease in the P. gingivalis level, yet it cannot eradicate the microorganism. Moreover, antibiotics can lead to bacterial resistance and undesirable side effects. This systematic review was performed to identify animal data defining antimicrobial photodynamic therapy (PACT) role on experimental PD models in the treatment of P. gingivalis. Embase, MEDLINE, and PubMed were examined for studies published from January 1980 to August 2018. MeSH terms and Scopus data were used to find more related keywords. Four studies were selected and reviewed by two independent researches with a structured tool for rating the research quality. The beneficial effect of PACT included reductions in P. gingivalis counts, bleeding on probing, redness, and inflammation on multiple sites (i.e., first molar, dental implants; subgingival; and mandibular premolars). Although our results suggest that PACT displays antimicrobial action on P. gingivalis, thus improving the PD, a nonuniformity in the PACT protocol and the limited number of studies included lead to consider that the bactericidal efficacy of PACT against periodontal pathogens in PD remains unclear.

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Title: Photodynamic antimicrobial chemotherapy has an overt killing effect on periodontal pathogens? A systematic review of experimental studies
Authors: Daniele Peron
Alexandre Bergamo
Renato Prates
Stella Sousa Vieira
Paulo de Tarso Camillo de Carvalho
Andrey Jorge Serra
Publication date: 01-10-2019
Publisher: Springer London
Keywords: Photodynamic Therapy
Phototherapy
Gingival Diseases
Cytostatic Therapy
Periodontal Pathogens
Published in: Lasers in Medical Science / Issue 8/2019
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-019-02806-4

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