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01-02-2018 | Original Article

Effect of light polarization on the efficiency of photodynamic therapy of basal cell carcinomas: an in vitro cellular study

Authors: M. JalalKamali, S. N. Nematollahi-Mahani, M. Shojaei, A. Shamsoddini, N. Arabpour

Published in: Lasers in Medical Science | Issue 2/2018

Abstract

In an in vitro study, the effect of light polarization on the efficiency of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) of basal cell carcinoma (BCC) was investigated. Three states of light polarization (non-polarized, linearly polarized, and circularly polarized) were considered. Cells were exposed to green (532 pm 20 nm) irradiation from light emitting diodes. Cell survival was measured by the colorimetric assay (WST-1) and Trypan blue staining. The colorimetric assay showed a pronounced decrease in the cell viability (up to 30%) using polarized light compared to the non-polarized one in the wavelength region used. Similar results were obtained by the cell counting method (20–30% increase in cell death). The observed effect was dependent on the concentration of photosensitizer. The effect is more expressed in the case of linearly polarized light compared to the circularly polarized one. Results show that the use of polarized light increases the efficiency of in vitro ALA-PDT of BCC. Utilizing polarized light, it is possible to obtain the same effect from PDT by lower concentrations of photosensitizer. Additionally, the concentration dependency of PDT response and photo-bleaching is also reduced.

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Title: Effect of light polarization on the efficiency of photodynamic therapy of basal cell carcinomas: an in vitro cellular study
Authors: M. JalalKamali
S. N. Nematollahi-Mahani
M. Shojaei
A. Shamsoddini
N. Arabpour
Publication date: 01-02-2018
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 2/2018
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-017-2369-5

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Effect of light polarization on the efficiency of photodynamic therapy of basal cell carcinomas: an in vitro cellular study

Abstract

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