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Lasers in Medical Science
Published in: Lasers in Medical Science 4/2017

01-05-2017 | Original Article

Transcranial LED therapy on amyloid-β toxin 25–35 in the hippocampal region of rats

Authors: Camila da Luz Eltchechem, Afonso Shiguemi Inoue Salgado, Renato Amaro Zângaro, Mário César da Silva Pereira, Ivo Ilvan Kerppers, Luis Augusto da Silva, Rodolfo Borges Parreira

Published in: Lasers in Medical Science | Issue 4/2017

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Abstract

Excessive Aβ deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to Alzheimer’s disease. Thirty rats (EG) were irradiated with light-emitting diode (photobiomodulation (PBM)) in the frontal region of the skull after being inoculated with the Aβ toxin in the hippocampus; 30 rats were used as the control group (CG). The analysis was conducted at 7, 14, and 21 days after irradiation. We observed a decreased in Aβ deposits in treated animals compared with animals in the CG. The behavioral and motor assessment revealed that the EG group covered a larger ground distance and explored the open field than the CG group on days 14 and 21 (p < 0.05). The EG group was statistically significant in the spatial memory test compared to the CG group on day 14. The use of PBM significantly reduced the presence of Aβ plaques and improved spatial memory and behavioral and motor skills in treated animals on day 21.
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Metadata
Title
Transcranial LED therapy on amyloid-β toxin 25–35 in the hippocampal region of rats
Authors
Camila da Luz Eltchechem
Afonso Shiguemi Inoue Salgado
Renato Amaro Zângaro
Mário César da Silva Pereira
Ivo Ilvan Kerppers
Luis Augusto da Silva
Rodolfo Borges Parreira
Publication date
01-05-2017
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 4/2017
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-017-2156-3

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