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Lasers in Medical Science
Published in: Lasers in Medical Science 7/2016

01-09-2016 | Original Article

Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography

Authors: Wan Qin, Ruikang K. Wang

Published in: Lasers in Medical Science | Issue 7/2016

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Abstract

Accurate measurement of edema volume is essential for the investigation of tissue response and recovery following a traumatic injury. The measurements must be noninvasive and repetitive over time so as to monitor tissue response throughout the healing process. Such techniques are particularly necessary for the evaluation of therapeutics that are currently in development to suppress or prevent edema formation. In this study, we propose to use optical coherence tomography (OCT) technique to image and quantify edema in a mouse ear model where the injury is induced by a superficial-thickness burn. Extraction of edema volume is achieved by an attenuation compensation algorithm performed on the three-dimensional OCT images, followed by two segmentation procedures. In addition to edema volume, the segmentation method also enables accurate thickness mapping of edematous tissue, which is an important characteristic of the external symptoms of edema. To the best of our knowledge, this is the first method for noninvasively measuring absolute edema volume.
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Metadata
Title
Assessment of edema volume in skin upon injury in a mouse ear model with optical coherence tomography
Authors
Wan Qin
Ruikang K. Wang
Publication date
01-09-2016
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 7/2016
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-016-1984-x

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