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European Journal of Clinical Microbiology & Infectious Diseases

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01-01-2022 | Facial Palsy | Brief Report

Comparison of the Euroimmun Borrelia ‘antibody index’ with Virotech immunoblot-based detection of intrathecal Borrelia antibody production for the diagnosis of Lyme neuroborreliosis

Authors: Erika De Bont, Katrien Lagrou, Melissa Depypere

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 1/2022

Abstract

For diagnosis of neuroborreliosis, calculation of the antibody index, based on Euroimmun Anti-Borrelia plus VlsE ELISA was compared to Virotech Borrelia Europe plus TpN17 immunoblot-based detection of Borrelia-specific intrathecal antibody production. CXCL13 results in cerebrospinal fluid were used to evaluate discordant results. A total of 64 serum/CSF pairs were analysed. Patients were classified according to European Federation of Neurological Societies criteria incorporating Virotech results. For the Euroimmun assay, a sensitivity of 100% and specificity of 94% was found. Agreement between the both tests was almost perfect (κ 0.81). Both methods are appropriate for the detection of Borrelia-specific intrathecal antibody production.

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Title: Comparison of the Euroimmun Borrelia ‘antibody index’ with Virotech immunoblot-based detection of intrathecal Borrelia antibody production for the diagnosis of Lyme neuroborreliosis
Authors: Erika De Bont
Katrien Lagrou
Melissa Depypere
Publication date: 01-01-2022
Publisher: Springer Berlin Heidelberg
Keywords: Facial Palsy
Neurologic Lyme Disease
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 1/2022
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04343-x

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Comparison of the Euroimmun Borrelia ‘antibody index’ with Virotech immunoblot-based detection of intrathecal Borrelia antibody production for the diagnosis of Lyme neuroborreliosis

Abstract

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