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European Journal of Clinical Microbiology & Infectious Diseases

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01-12-2021 | Streptococci | Brief Report

Protective role of IL-18 in host defenses against group B Streptococcus

Authors: G. Mancuso, A. Midiri, C. Beninati, S. Zummo, C. Biondo

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 12/2021

Abstract

The aim of this study was to investigate the role of IL-18, a member of the IL-1 family, in group B Streptococcus (GBS) infection. Both in a neonatal and adult model of GBS infection, IL-18-deficient animals were significantly more susceptible to infection than WT animals. The lack of IL18 was associated with a marked reduction in IFN-γ-levels after bacterial stimulation but did not play a significant role in the recruitment of PMN to sites of GBS infection. Collectively, our data document a fundamental function of IL-18 signaling in boosting the host immune responses against GBS infection.

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Title: Protective role of IL-18 in host defenses against group B Streptococcus
Authors: G. Mancuso
A. Midiri
C. Beninati
S. Zummo
C. Biondo
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Streptococci
Cytokines
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 12/2021
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04299-y

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