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European Journal of Clinical Microbiology & Infectious Diseases

Published in:

01-07-2018 | Review

Plasmids carrying DHA-1 β-lactamases

Authors: Claire Hennequin, Viviane Ravet, Frédéric Robin

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 7/2018

Abstract

The aim of this review is to provide an update on the plasmids mediating DHA-1 cephalosporinase in Klebsiella pneumoniae. These plasmids have been mainly found in this bacterium but not only. The first was isolated from Salmonella sp. in France in the early 1990s. They are currently reported worldwide. Bla_DHA-1 beta-lactamase gene is usually co-expressed with many other antibiotic resistance genes such as extended-spectrum β-lactamases (bla_CTX-M-, bla_SHV-types), oxacillinases (bla_OXA-1, bla_OXA-30), penicillinases (bla_TEM-type), carbapenemases (bla_OXA48, bla_KPC-2), aminoglycosides (aacA, aadA, armA), fluoroquinolones (qnrB4, aac6′-1b-cr), and sulfonamide (sul1) resistance genes. Plasmids carrying DHA-1 cephalosporinase have different sizes (22 to 313 kb), belong to diverse groups of incompatibility (R, L/M, FII(k), FIB, A/C2, HI2, HIB), and are self-transferable or not. The multidrug resistance region consists of a mosaic structure composed of resistance genes, insertion sequences, composite transposon, and integrons.

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Title: Plasmids carrying DHA-1 β-lactamases
Authors: Claire Hennequin
Viviane Ravet
Frédéric Robin
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 7/2018
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-018-3231-9

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