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23-04-2022 | Astrocytoma | Brief Communication

Superficial siderosis in long-standing pilocytic astrocytoma

Authors: Alessandra Erbetta, Filippo Savoldi, Valentina Opancina, Gianluca Marucci, Marco Schiariti, Veronica Redaelli, Elisa F. M. Ciceri, Luisa Chiapparini

Published in: Neurological Sciences | Issue 7/2022

Abstract

Background

Pilocytic astrocytoma (PA) rarely spreads along neuraxis, and association with superficial siderosis (SS) and chronic signs of intracranial hypertension is exceptional.

Case report

A 48-year-old woman presented with slow onset hearing loss in the past year. Clinical examination revealed dysarthria, positive Romberg test, and severe optic neuropathy. Cerebrospinal fluid (CSF) analysis showed numerous red blood cells, increased proteins and LDH, and high opening pressure. Brain and spine MRI demonstrated extensive superficial siderosis, bone remodeling of the skull base and spine, and diffuse nodular leptomeningeal enhancement. Histological examination of a nodule in the dorsal spine evidenced PA.

Conclusion

We report a case of PA associated with dural remodeling and SS. The mechanism of SS is unclear but might be related to meningeal tumor infiltration and altered CSF composition and resorption.

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Farb RI, Nicholson PJ, Peng PW et al (2019) Spontaneous intracranial hypotension: a systematic imaging approach for CSF leak localization and management based on MRI and digital subtraction myelography. Am J Neuroradiol 40:745–753. https://doi.org/10.3174/ajnr.A6016CrossRefPubMedPubMedCentral

Title: Superficial siderosis in long-standing pilocytic astrocytoma
Authors: Alessandra Erbetta
Filippo Savoldi
Valentina Opancina
Gianluca Marucci
Marco Schiariti
Veronica Redaelli
Elisa F. M. Ciceri
Luisa Chiapparini
Publication date: 23-04-2022
Publisher: Springer International Publishing
Keywords: Astrocytoma
Astrocytoma
Astrocytoma
Magnetic Resonance Imaging of the Spine
Hypertension
Dysarthria
Intracranial Hypertension
Published in: Neurological Sciences / Issue 7/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06077-w

At a glance: The STEP trials

Springer Medicine

Superficial siderosis in long-standing pilocytic astrocytoma

Abstract

Background

Case report

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case report

Conclusion

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