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Neurological Sciences

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01-04-2022 | Osteonecrosis | Original Paper

Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population

Authors: Jun Xiong, Yi Niu, Wei Liu, Fan Zeng, Jian-Fei Cheng, Shi-Qiang Chen, Xiang-Zhou Zeng

Published in: Neurological Sciences | Issue 4/2022

Abstract

Purpose

Alcohol-induced osteonecrosis femoral head necrosis (ONFH) is a disease that seriously affects human health. Abnormal expression of L3MBTL3/PTPN9 gene can cause a variety of human diseases. The purpose of this study is to investigate the effect of L3MBTL3/PTPN9 gene polymorphism on the susceptibility of alcohol-induced ONFH in Chinese Han population.

Methods

A total of 308 alcohol‐induced ONFH patients and 425 healthy controls were enrolled in this case–control study. Alleles, genotypes, genetic models, haplotypes, and multifactor dimensionality reduction analyses (MDR) based on age-corrected by using odds ratio (OR) and 95% confidence interval (CI) were performed.

Results

Our result revealed rs2068957 in the L3MBTL3 gene increased the risk of alcohol ONFH under the recessive model after correction. Besides, we also found that rs75393192 in the PTPN9 gene was a protective site in stratification over 40 years of age and stage. In stratified analysis of necrotic sites, we only found that rs2068957 was associated with increased susceptibility of alcohol-induced ONFH under the co-dominant model and recessive model. Haplotype “GC” in the block (rs76107647|rs10851882 in PTPN9 gene) significantly decreased the susceptibility of alcoholic ONFH.

Conclusions

Our results provide evidence that L3MBTL3/PTPN9 polymorphisms are associated with alcohol-induced ONFH risk in Chinese Han population.

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Title: Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population
Authors: Jun Xiong
Yi Niu
Wei Liu
Fan Zeng
Jian-Fei Cheng
Shi-Qiang Chen
Xiang-Zhou Zeng
Publication date: 01-04-2022
Publisher: Springer International Publishing
Keywords: Osteonecrosis
Osteonecrosis of the Femoral Head
Published in: Neurological Sciences / Issue 4/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05486-7

At a glance: The STEP trials

Springer Medicine

Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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