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Open Access 01-04-2022 | Insomnia | Original Article

Polysomnographic correlates of sleep disturbances in de novo, drug naïve Parkinson’s Disease

Authors: Beatrice Orso, Francesco Famà, Laura Giorgetti, Pietro Mattioli, Andrea Donniaquio, Nicola Girtler, Andrea Brugnolo, Federico Massa, Enrico Peira, Matteo Pardini, Silvia Morbelli, Flavio Nobili, Dario Arnaldi

Published in: Neurological Sciences | Issue 4/2022

Abstract

Background

Sleep disturbances are common non-motor symptoms of Parkinson’s Disease (PD).

Methods

The aim of this study was to investigate the polysomnographic correlates of sleep changes, as investigated by the Parkinson’s Disease Sleep Scale-2 (PDSS-2), in a cohort of sixty-two consecutive de novo, drug naïve PD patients (71.40 ± 7.84 y/o).

Results

PDSS-2 total score showed a direct correlation with stage shifts (p = 0.008). Fragmented sleep showed an inverse correlation with sleep efficiency (p = 0.012). Insomnia symptoms showed an inverse correlation with wake after sleep onset (p = 0.005) and direct correlation with periodic leg movements (p = 0.006) and stage shift indices (p = 0.003). Motor Symptoms showed a direct correlation with Apnoea-Hypopnoea (AHI; p = 0.02) and awakenings indices (p = 0.003). Dream distressing showed a direct correlation with REM without atonia (RWA, p = 0.042) and an inverse correlation with AHI (p = 0.012). Sleep quality showed an inverse correlation with RWA (p = 0.008).

Conclusion

PDSS-2 features are significantly correlated with polysomnography objective findings, thus further supporting its reliability to investigate sleep disturbances in PD patients.

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Title: Polysomnographic correlates of sleep disturbances in de novo, drug naïve Parkinson’s Disease
Authors: Beatrice Orso
Francesco Famà
Laura Giorgetti
Pietro Mattioli
Andrea Donniaquio
Nicola Girtler
Andrea Brugnolo
Federico Massa
Enrico Peira
Matteo Pardini
Silvia Morbelli
Flavio Nobili
Dario Arnaldi
Publication date: 01-04-2022
Publisher: Springer International Publishing
Keywords: Insomnia
Polysomnography
Parkinson's Disease
Published in: Neurological Sciences / Issue 4/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05622-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Polysomnographic correlates of sleep disturbances in de novo, drug naïve Parkinson’s Disease

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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