Top

Published in:

01-05-2019 | Migraine | Review Article

The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review

Authors: G. D’Andrea, A. Gucciardi, F. Perini, A. Leon

Published in: Neurological Sciences | Special Issue 1/2019

Abstract

The pathogenesis underlying cluster headache remains an unresolved issue. Although both the autonomic system and the hypothalamus play a central role, the modality of their involvement remains largely unknown. It is, also, unknown why the duration of the pain attacks is so brief and why their onset and termination are abrupt and extremely painful. This review summarizes the evidence to date accumulated in favor of a possible role of anomalies in the metabolism of tyrosine, tryptophan, and arginine in these unresolved issues.

Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3 edition (beta version). Cephalalgia 33(9):627–808CrossRef

Altiokka O, Mutluay B, Koksal A, Ciftci-Kavaklioglu B, Ozturk M, Altunkaynak Y, Baybas S, Soysal A (2016) Evaluation of interictal autonomic function during attack and remission in cluster headache. Cephalalgia 36(1):37–43CrossRefPubMed

D’Andrea G, Terrazzino S, Leon A, Fortin D, Perini F, Granella F, Bussone G (2004) Elevated levels of circulating trace amines in primary headaches. Neurology 62:1701–1705CrossRefPubMed

D’Andrea G, Granella F, Perini F et al (2006) Platelet levels of dopamine are increased in migraine and cluster headache. Headache 26:585–591CrossRef

Axelrod J, Saavedra JM (1977) Octopamine. Nature 265:501–504CrossRefPubMed

Balbi T, Fusco M, Vasapollo D, Boschetto R, Cocco P, Leon A, Farruggio A (2005) The presence of trace amines in postmortem cerebrospinal fluid in humans. J Forensic Sci 50(3):630–632CrossRefPubMed

D’Andrea G, Leon A (2010) Pathogenesis of migraine: from neurotransmitters to neuromodulators and beyond. NeurolSci 24:S1–S7

Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001) Traces amines: identification of a family of mammalian G protein-coupled receptors. Proc NatlAcadSci USA 98:8966–8971CrossRef

Khan MZ, Nawaz W (2016) The emerging role of human trace amines and human trace amine associated receptor (hTAARs) in central nervous system. Biomed Pharmacother 83:439–449

10.

Gainetdinov RR, Hoener MC, Berry MD (2018) Trace amines and their receptors. Pharacol Rev 70(3): 549–620

11.

D’Andrea G, Cananzi AR, Perini F, Hasselmark L (1995) Platelet model and their possible usefulness in the study of migraine pathogenesis. Cephalalgia 15(4):265–271CrossRefPubMed

12.

D’Andrea G, Granella F, Perini F, Farruggio A, Leone M, Bussone G (2006) Platelet levels of dopamine are increased in migraine and cluster headache. Headache 48(4):585–591CrossRef

13.

Johnson ES (1978) A basis for migraine therapy-the autonomic theory reappraised. Postgrad Med J 54(630):231–243CrossRefPubMedPubMedCentral

14.

Godsby PJ (2002) Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. Lancet Neurol 1(4):251–257CrossRef

15.

D’Andea G, Terrazzino S, Leon A, Fortin D et al (2004) Elevated levels of circulating trace amines in primary headaches. Neurology 62:1701–1705CrossRef

16.

D’Andrea G, Cevoli S, Colavito D, Leon A (2015) Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism. Neurol Sci 36(Suppl 1):17–22CrossRefPubMed

17.

D’Andrea G, D’Andrea G, D’Arrigo A, Dalle Carbonare M, Leon A (2012) Pathogenesis of migraine: the role of the neuromodulators. Headache 52(7):1155–1163CrossRefPubMed

18.

Diniz DA, Petrocchi JA, Navarro LC, Souza TV et al (2018) Serotonin induces peripheral antinociception via opioidergic system. Biomed Pharmacother 97:14–34.1437CrossRef

19.

D’Andrea G, Granella F, Alecci M et al (1998) Serotonin metabolism in cluster headache. Cephalalgia 18(2):94–96CrossRefPubMed

20.

D’Andrea G, Leone M, Bussone G, Bolner A, Leon A et al (2017) Abnormal tyrosine metabolism in chronic cluster headache. Cephalalgia 37(2):148–153CrossRefPubMed

21.

Wollman H, Nilson E, Antonin KH, Reiderer P 1985 Tryptamine kinetics in human volunteers. In: Bolton AA, Maite L., Beick PR (eds) Neuropsychopharmacology of trace amines. Humana Press Clifton pg 361–378

22.

Huo FQ, Huang FS, Lu BC et al (2010) Activation of serotonin 1A receptors in ventrolateral orbital cortex depresses persistent nociception: a presynaptic inhibition mechanism. Neurochem Int 57(7):749–755CrossRefPubMed

23.

Qu GL, Huo FQ, Huang FS (2008) The role of 5-HT receptors in medial prefrontal cortex of 5-HT induced antinociception in the rat. Neuroscience 152:487–494CrossRefPubMed

24.

Huo FQ, Qu GL, Ly YQ et al (2008) GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT_1A receptor activation-induced antinociception in the rat. Pain 139(2):398–405CrossRefPubMed

25.

D’Andrea G, D’Amico D, Bussone G, Bolner A, Aguggia M, Saracco MG, Galloni E, de Riva V, D’Arrigo A, Colavito D, Leon A, Perini F (2014) Tryptamine levels are low in plasma of chronic migraine and chronic tension-type headache. Neurol Sci 35:1941–1945CrossRefPubMed

26.

D’Andrea G, Granella F, Cataldini M (2003) Platelet aggregation profile in cluster headache. Headache 43(3):272–275CrossRefPubMed

27.

Steinberg A, Wiklund PN, Brundin L et al (2010) Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. Cephalalgia 30(6):696–702CrossRefPubMed

28.

Anwar MA, Ford WR, Broadley KJ, Herbert AA (2012) Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine. Br J Pharmacol 165(7):2191–2202CrossRefPubMedPubMedCentral

29.

Boger HD, Bode-Boger SM (2001) The clinical pharmacology of l-arginine. Annu Rev Pharacol Toxicol 41:79–99CrossRef

30.

D’Andrea G, Bussone G, Di Fiore P, Perini F, Gucciardi A et al (2018) Pathogenesis of chronic cluster headache and bouts: role of tryptamine, arginine metabolism and α₁ agonists. Neurol Sci 38(suppl 1):S37–S43

31.

D’Andrea G, Cananzi AR, Morra M, Martignoni E, Fornasiero S, Zamberlan F, Grunfeld S, Welch KMA (1992) Platelet catecholamines in cluster headache. J neurol Neurosug Psych 55:308–309CrossRef

32.

Strittmatter M, Hamann GF, Blaes F, Grauer M et al (1996) Reduced sympathetic nervous system activity during the cluster period of cluster-headache. Schweiz Med Wochenschr 126(24):1054–1061PubMed

33.

Danielson TJ, Boulton AA, Robertson HS (1977) m-Octopamine, p-octopamine and phenylethylamine in mammalian brain: a sensitive specific assay and effects of drugs. J Neurochem 29:1131–1111CrossRefPubMed

34.

May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ (2000) PET and MRA findings in in cluster headache and MRA in experimental pain. Neurology 55:1328–1335CrossRefPubMed

35.

Piacentino M, D’Andrea G, Perini F, Volpin L (2014) Drug-resistant cluster headache: long-term evaluation of pain control by posterior hypothalamic deep-brain stimulation. World Neurosurg 81(2):442CrossRefPubMed

36.

Ferrari E, Canepari C, Sossolo PA, Martignoni E, Micieli G, Nappi G (1983) Changes of biological rhythms in primary headache syndrome. Cephalalgia 3(Suppl 1):58–68CrossRefPubMed

37.

Wadelind E, Gutafsson SA (1987) Prolactin in cluster headache diurnal secretion, response to thyrotropin-releasing hormone and relation to sex steroid and gonadotropins. Cephalalgia 7:43–54

38.

Crwoley WR (2015) Neuroendocrine regulation of lactation and milk production. Compr Physiol 5(1):255–291

39.

D’Andrea G, Leone M, Bussone G, Fiore P, Bolner A, Aguggia M et al (2017) Abnormal tyrosine metabolism in chronic cluster headache. Cephalalgia 37(2):148–153CrossRefPubMed

40.

Leone M, Attanasio A, Croci D, Grazzi L et al (1997) The m-chlorophenylpiperazine test in cluster headache: a study on central serotoninergic activity. Cephalalgia 17(6):666–667CrossRefPubMed

41.

Flam BR, Eichler DC, Solomanson LP (2007) Endothelial nitric oxide production is tightly coupled to citrulline-NO cycle. Nitric Oxide 17(3–4):115–121CrossRefPubMed

42.

Broadly PB (2010) The vascular effects of trace amines and amphetamines. Pharmacol Ther 125:363–375CrossRef

43.

44.

D’Andrea G, Perini F, Granella F, Cananzi A, Sergi A (1995) Efficacy of transdermal clonidine in short-term treatment of cluster headache: a pilot study. Cephalalgia 15(5):430–433CrossRefPubMed

Title: The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review
Authors: G. D’Andrea
A. Gucciardi
F. Perini
A. Leon
Publication date: 01-05-2019
Publisher: Springer International Publishing
Keywords: Migraine
Cluster Headache
Published in: Neurological Sciences / Issue Special Issue 1/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03768-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Special Issue 1/2019

When does the brain choose pain?

Catastrophizing attitude changes after onabotulinumtoxin A treatment in chronic migraine

Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache

Does the migraine attack start in the cortex and is the cortex critical in the migraine process?

Trigeminal autonomic cephalalgias: spectrum or continuum? Insights from a family

Clinical issues of headaches: a personal view