Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Neurological Sciences
Published in: Neurological Sciences 12/2014

01-12-2014 | Original Article

The responsiveness of TrkB to exogenous BDNF in frontal cortex during antibiotic treatment of Streptococcus pneumoniae meningitis

Authors: Xiaoqing Song, Di lian, Dake He, Jiaming Sun, MingJie Zhu, Ling Li

Published in: Neurological Sciences | Issue 12/2014

Login to get access

Abstract

Our previous studies suggested that the expression of TrkB and BDNF decreased concomitantly in brain during Streptococcus pneumoniae meningitis after antibiotic treatment, and that adjuvant administration of exogenous BDNF could rescue neurons from S. pneumoniae meningitis. In this study, we investigated the responsiveness of TrkB to exogenous BDNF treatment in frontal cortex during antibiotic treatment of S. pneumoniae meningitis. We found that adjuvant administration of exogenous BDNF led to increased number of survived neurons, improved the conduction of central auditory pathway and neurological disfunction, and up-regulated TrkB expression at the mRNA level in the frontal cortex of rats under S. pneumonia meningitis (P < 0.01). When treated with placebo, on the contrary, neurons in the frontal cortex of control rats were seriously damaged and the TrkB expression was remarkably decreased. These findings indicated that exogenous BDNF could up-regulate TrkB expression and thus played a neuroprotective role in frontal cortex injury from S. pneumoniae meningitis. They further confirmed our previous report that the decrease of intrinsic BDNF and TrkB expression is involved in the pathogenesis of neurological brain damage during S. pneumoniae meningitis after antibiotic treatment.
Literature
1.
Mook-Kanamori Barry B, Geldhoff Madelijn, van der Poll Tom, van de Beek Diederik (2011) Pathogenesis and pathophysiology of pneumococcal meningitis. Clin Microbiol Rev 24(3):557–591PubMedCentralPubMedCrossRef
2.
Kastenbauer S, Pfister H-W (2003) Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 126:1015–1025PubMedCrossRef
3.
Chao YN, Chiu NC, Huang FY (2008) Clinical features and prognostic factors in childhood pneumococcal meningitis. J Microbiol Immunol Infect 41(1):48–53PubMed
4.
van de Beek D, Schmand B, de Gans J, Weisfelt M, Vaessen H, Dankert J, Vermeulen M (2002) Cognitive impairment in adults with good recovery after bacterial meningitis. J Infect Dis 186:1047–1052PubMedCrossRef
5.
Fritz D, Brouwer MC, van de Beek D (2012) Dexamethasone and long-term survival in bacterial meningitis. Neurology 79(22):2177–2179PubMedCrossRef
6.
Weisfelt M, van de Beek D, Spanjaard L, Reitsma JB, de Gans J (2006) Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol 5:123–129PubMedCrossRef
7.
Brandt CT (2010) Experimental studies of pneumococcal meningitis. Dan Med Bull 57:B4119PubMed
8.
9.
Gupta VK, You Y, Gupta VB, Klistorner A, Graham SL (2013) TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Int J Mol Sci 14(5):10122–10142PubMedCentralPubMedCrossRef
10.
Tonchev AB (2011) Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. Arch Ital Biol 149(2):225–231PubMed
11.
Nagahara AH, Tuszynski MH (2011) Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 10(3):209–219PubMedCrossRef
12.
Li L, Shui QX, Zhao ZY (2003) Regulation of brain-derived neurotrophic factor (BDNF) expression following antibiotic treatment of experimental bacterial meningitis. J Child Neurol 18:828–834PubMedCrossRef
13.
Li Ling, Shui Quan-Xiang, Zhao Zheng-Yan, Zhu Xiao-Dong, Bao Wei-Qing (2011) Dynamic changes of TrkB gene expression in Streptococcus pneumoniae meningitis after treatment with antibiotics and dexamethasone. World J Pediatr 7(3):250–256PubMedCrossRef
14.
Li L, Shui QX, Liang K, Ren H (2007) Brain-derived neurotrophic factor rescues neurons from bacterial meningitis. Pediatr Neurol 36:324–329PubMedCrossRef
15.
Cheng Y, Gidday JM, Yan Q, Shah AR, Holtzman DM (1997) Marked age-dependent neuroprotection by brain derived neurotrophic factor against neonatal hypoxic ischemic brain injury. Ann Neurol 41:521–529PubMedCrossRef
16.
Diab A, Zhu J, Lindquist L, Wretlind B, Bakhiet M, Link H (1997) Haemophilus influenzae and Streptococcus pneumoniae induce different intracerebral mRNA cytokine patterns during the course of experimental bacterial meningitis. Clin Exp Immunol 109:233–241PubMedCentralPubMedCrossRef
17.
Li Ling, Shui Quan-Xiang, Li Xianzhen (2005) Neuroprotective effects of brain-derived neurotrophic factor (BDNF) on hearing in experimental pneumococcal meningitis. J Child Neurol 20:51–56PubMedCrossRef
18.
Barichello T, Belarmino E Jr, Comim CM, Cipriano AL, Generoso JS, Savi GD, Stertz L, Kapczinski F, Quevedo J (2010) Correlation between behavioral deficits and decreased brain-derived neurotrophic factor in neonatal meningitis. J Neuroimmunol 223(1–2):73–76PubMedCrossRef
19.
Kothari R, Singh R, Singh S, Jain M, Bokariya P, Khatoon M (2010) Neurophysiologic findings in children with spastic cerebral palsy. J Pediatr Neurosci 5(1):12–17PubMedCentralPubMedCrossRef
20.
Nakamura M (1989) Prognostic evaluation of severe brain damage by auditory brainstem evoked potentials (BAEPs). No To Shinkei 41(3):273–281PubMed
21.
Leib SL, Tauber MG (1999) Pathogenesis of bacterial meningitis. Infect Dis Clin North Am 13(3):527–548PubMedCrossRef
22.
Granert C, Raud J, Waage A, Lindquist L (1999) Effects of polysaccharide fucoidin on cerebrospinal fluid interleukin-1 and tumor necrosis factor alpha in pneumococcal meningitis in the rabbit. Infect Immun 67(5):2071–2074PubMedCentralPubMed
23.
Aloe L, Properzi F, Probert L, Akassoglou K, Kassiotis G, Micera A, Fiore M (1999) Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal. Brain Res 840(1-2):125–137PubMedCrossRef
24.
Tong L, Balazs R, Soiampornkul R, Thangnipon W, Cotman CW (2008) Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging 29(9):1380–1393PubMedCentralPubMedCrossRef
25.
Kairisalo M, Korhonen L, Sepp M, Pruunsild P, Kukkonen JP, Kivinen J, Timmusk T, Blomgren K, Lindholm D (2009) NF-kappaB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein. Eur J Neurosci 30(6):958–966PubMedCrossRef
26.
Ferrer I, Ballabriga J, Martí E, Pérez E, Alberch J, Arenas E (1998) BDNF up-regulates TrkB protein and prevents the death of CA1 neurons following transient forebrain ischemia. Brain Pathol 8(2):253–261PubMedCrossRef
27.
Gomes Joa˜o R, Costa Joa˜o T, Melo Carlos V, Felizzi Federico, Monteiro Patrícia, Pinto Maria J, Ina´cio Ana R, Wieloch Tadeusz, Almeida Ramiro D, Gra˜os Ma´rio, Duarte Carlos B (2012) Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons. J Neurosci 32(13):4610–4622PubMedCrossRef
28.
29.
30.
Numakawa T, Suzuki S, Kumamaru E, Adachi N, Richards M, Kunugi H (2010) BDNF function and intracellular signaling in neurons. Histol Histopathol 25(2):237–258PubMed
31.
Almeida RD, Manadas BJ, Melo CV, Gomes JR, Mendes CS, Gra˜os MM, Carvalho RF, Carvalho AP, Duarte CB (2005) Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ 12:1329–1343PubMedCrossRef
32.
Huang EJ, Reichardt LF (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72:609–642PubMedCrossRef
33.
34.
Ohira K, Hayashi M (2009) A new aspect of the TrkB signaling pathway in neural plasticity. Current Neuropharmacol 7(4):276–285CrossRef
35.
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661–665PubMedCrossRef
36.
Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286:1358–1362PubMedCrossRef
Metadata
Title
The responsiveness of TrkB to exogenous BDNF in frontal cortex during antibiotic treatment of Streptococcus pneumoniae meningitis
Authors
Xiaoqing Song
Di lian
Dake He
Jiaming Sun
MingJie Zhu
Ling Li
Publication date
01-12-2014
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 12/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-014-1862-x

Other articles of this Issue 12/2014

Neurological Sciences 12/2014 Go to the issue

Original Article

Electroencephalographic and behavioral effects of intracerebroventricular or intraperitoneal injections of toxic honey extract in adult Wistar rats and GAERS

Brief Communication

Attitude of epilepsy patients and their attendants for participating in research on status epilepticus

Original Article

Decreased antioxidant status in migraine patients with brain white matter hyperintensities

Original Article

Lentivirus-mediated delivery of sonic hedgehog into the striatum stimulates neuroregeneration in a rat model of Parkinson disease

Brief Communication

Are atraumatic spinal needles as efficient as traumatic needles for lumbar puncture?

Original Article

Maintenance and manipulation of object sequences in working memory: a lifespan study