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Published in: Clinical Rheumatology 2/2021

01-02-2021 | Influenza Vaccination | Letter to the Editor

COVID-19 vaccination in immunocompromised patients

Authors: Bhavin Sonani, Fawad Aslam, Amandeep Goyal, Janki Patel, Pankaj Bansal

Published in: Clinical Rheumatology | Issue 2/2021

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Excerpt

Almost 1 year into the coronavirus disease 2019 (COVID-19) pandemic, and after more than 50 million cases and 1.35 million deaths globally, reports of the successful conclusion of phase III trials of two vaccines, BNT162b2 and mRNA1273, are most welcoming. Results from phase I/II for both these vaccines were highly encouraging with strongly elicited humoral as well as cellular responses, and no trial-limiting safety concerns [1, 2]. According to the preliminary data release, both vaccines have been reported to be almost 95% effective in preventing COVID-19 in their phase II/III trials [3, 4]. Further, the risk of severe illness from COVID-19 has been reported to be lowered by more than 90% after vaccination in both clinical trials [3, 4]. …
Literature
1.
go back to reference Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, Baum A, Pascal K, Quandt J, Maurus D, Brachtendorf S, Lörks V, Sikorski J, Hilker R, Becker D, Eller AK, Grützner J, Boesler C, Rosenbaum C, Kühnle MC, Luxemburger U, Kemmer-Brück A, Langer D, Bexon M, Bolte S, Karikó K, Palanche T, Fischer B, Schultz A, Shi PY, Fontes-Garfias C, Perez JL, Swanson KA, Loschko J, Scully IL, Cutler M, Kalina W, Kyratsous CA, Cooper D, Dormitzer PR, Jansen KU, Türeci Ö (2020) COVID-19 vaccine BNT162b1 elicits human antibody and T H 1 T cell responses. Nature 586:594–599. https://doi.org/10.1038/s41586-020-2814-7CrossRefPubMed Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, Baum A, Pascal K, Quandt J, Maurus D, Brachtendorf S, Lörks V, Sikorski J, Hilker R, Becker D, Eller AK, Grützner J, Boesler C, Rosenbaum C, Kühnle MC, Luxemburger U, Kemmer-Brück A, Langer D, Bexon M, Bolte S, Karikó K, Palanche T, Fischer B, Schultz A, Shi PY, Fontes-Garfias C, Perez JL, Swanson KA, Loschko J, Scully IL, Cutler M, Kalina W, Kyratsous CA, Cooper D, Dormitzer PR, Jansen KU, Türeci Ö (2020) COVID-19 vaccine BNT162b1 elicits human antibody and T H 1 T cell responses. Nature 586:594–599. https://​doi.​org/​10.​1038/​s41586-020-2814-7CrossRefPubMed
2.
go back to reference Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott A, Flach B, Doria-Rose NA, Corbett KS, Morabito KM, O'Dell S, Schmidt SD, Swanson PA 2nd, Padilla M, Mascola JR, Neuzil KM, Bennett H, Sun W, Peters E, Makowski M, Albert J, Cross K, Buchanan W, Pikaart-Tautges R, Ledgerwood JE, Graham BS, Beigel JH, mRNA-1273 Study Group (2020) An mRNA vaccine against SARS-CoV-2 - preliminary report. N Engl J Med 383:1920–1931. https://doi.org/10.1056/NEJMoa2022483CrossRef Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott A, Flach B, Doria-Rose NA, Corbett KS, Morabito KM, O'Dell S, Schmidt SD, Swanson PA 2nd, Padilla M, Mascola JR, Neuzil KM, Bennett H, Sun W, Peters E, Makowski M, Albert J, Cross K, Buchanan W, Pikaart-Tautges R, Ledgerwood JE, Graham BS, Beigel JH, mRNA-1273 Study Group (2020) An mRNA vaccine against SARS-CoV-2 - preliminary report. N Engl J Med 383:1920–1931. https://​doi.​org/​10.​1056/​NEJMoa2022483CrossRef
8.
go back to reference Hua C, Barnetche T, Combe B, Morel J (2014) Effect of methotrexate, anti-tumor necrosis factor α, and rituximab on the immune response to influenza and pneumococcal vaccines in patients with rheumatoid arthritis: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 66:1016–1026. https://doi.org/10.1002/acr.22246CrossRef Hua C, Barnetche T, Combe B, Morel J (2014) Effect of methotrexate, anti-tumor necrosis factor α, and rituximab on the immune response to influenza and pneumococcal vaccines in patients with rheumatoid arthritis: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 66:1016–1026. https://​doi.​org/​10.​1002/​acr.​22246CrossRef
Metadata
Title
COVID-19 vaccination in immunocompromised patients
Authors
Bhavin Sonani
Fawad Aslam
Amandeep Goyal
Janki Patel
Pankaj Bansal
Publication date
01-02-2021
Publisher
Springer International Publishing
Published in
Clinical Rheumatology / Issue 2/2021
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-020-05547-w

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