Skip to main content
Top
Published in: Clinical Rheumatology 9/2017

01-09-2017 | Original Article

Nailfold videocapillaroscopy results in patients with rheumatoid arthritis

Authors: Sinem Sag, Mustafa Serdar Sag, Ibrahim Tekeoglu, Ayhan Kamanli, Kemal Nas, Yıldıray Aydın

Published in: Clinical Rheumatology | Issue 9/2017

Login to get access

Abstract

We aimed to analyse the nailfold capillaryscopy findings morphologically and examine their relationship with disease activity and demographic characteristics in patients with rheumatoid arthritis. In accordance with the 2010 ACR/EULAR classification criteria, 201 patients diagnosed with Romatoiad artrit (RA) and 50 healthy controls were included. We analysed capillaroscopic abnormalities such asmegacapillaries, haemorrhages, ramifications and avascular areas in patients affected with rheumatoid arthritis. The findings in our study are as follows: in 45.77% of the RA patients, there were nonspecific capillaryscopy findings. When compared to control group, the incidence of tortuosity, dilated capillary and bushy capillary was higher in RA patients (p values, respectively, 0.110, 0.330, 0.440 and 0.516). In RA patients with Raynaud’s phenomenon, the incidence of nonspecific capillaryscopy findings was higher. While there is a weak relationship between tortuosity and the duration of disease, no significant relation was detected between capillaryscopy findings and parameters such as RF, anti-CCP positivity and disease activity score (DAS28). When compared to controls, we have detected that RA patients have more nonspecific capillaryscopic findings. We could not find a relationship between nonspecific capillaryscopic findings and RA’a clinical findings and laboratory parameters. There is a need for a long-term wider-scale follow-up study to investigate whether there is a capillaryscopic pattern that can be correlated with RA’s clinical findings.
Literature
1.
go back to reference Lambova SN, Müller-Ladner U (2013) Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? Rheumatol Int 33(3):689–695CrossRefPubMed Lambova SN, Müller-Ladner U (2013) Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? Rheumatol Int 33(3):689–695CrossRefPubMed
2.
go back to reference LeRoy EC, Medsger TA (2001) Criteria for the classification of early systemic sclerosis. J Rheumatol 28:1573–1576PubMed LeRoy EC, Medsger TA (2001) Criteria for the classification of early systemic sclerosis. J Rheumatol 28:1573–1576PubMed
3.
go back to reference Van den Hoogen F, Khanna D, Fransen J et al (2013) 2013 classification criteria for systemic sclerosis: an american college of rheumatology/European league against rheumatism collaborative initiative. Arthritis & Rheumatism 65(11):2737–2747CrossRef Van den Hoogen F, Khanna D, Fransen J et al (2013) 2013 classification criteria for systemic sclerosis: an american college of rheumatology/European league against rheumatism collaborative initiative. Arthritis & Rheumatism 65(11):2737–2747CrossRef
4.
go back to reference Cutolo M, Pizzorni C, Secchi ME, Sulli A (2008) Capillaroscopy. Best Pract Res Clin Rheumatol 22(6):1093–1108CrossRefPubMed Cutolo M, Pizzorni C, Secchi ME, Sulli A (2008) Capillaroscopy. Best Pract Res Clin Rheumatol 22(6):1093–1108CrossRefPubMed
5.
go back to reference Lambova SN, Hermann W, Müller-Ladner U (2012) Comparison of qualitative and quantitative analysis of capillaroscopic findings in patients with rheumatic diseases. Rheumatol Int 32:3729–3735CrossRefPubMed Lambova SN, Hermann W, Müller-Ladner U (2012) Comparison of qualitative and quantitative analysis of capillaroscopic findings in patients with rheumatic diseases. Rheumatol Int 32:3729–3735CrossRefPubMed
6.
go back to reference Graceffa D, Amorosi B, Maiani E, Bonifati C, Chimenti MS, Perricone R, Di Carlo A (2013) Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis. Arthritis 2013:957480CrossRefPubMedPubMedCentral Graceffa D, Amorosi B, Maiani E, Bonifati C, Chimenti MS, Perricone R, Di Carlo A (2013) Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis. Arthritis 2013:957480CrossRefPubMedPubMedCentral
7.
go back to reference Moreli S, Ferri C, Polettini E, Bellini C, Gualdi GF, Pittoni V, Valesini G, Santucci A (1995) Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis. Am J Med 99:255–260CrossRef Moreli S, Ferri C, Polettini E, Bellini C, Gualdi GF, Pittoni V, Valesini G, Santucci A (1995) Plasma endothelin-1 levels, pulmonary hypertension, and lung fibrosis in patients with systemic sclerosis. Am J Med 99:255–260CrossRef
8.
go back to reference Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S (2005) Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 24:111–116CrossRefPubMed Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S (2005) Soluble adhesion molecules (sVCAM-1, sE-selectin), vascular endothelial growth factor (VEGF) and endothelin-1 in patients with systemic sclerosis: relationship to organ systemic involvement. Clin Rheumatol 24:111–116CrossRefPubMed
9.
go back to reference Ballara S, Taylor PC, Reusch P, Marme D, Maini RN, Paleolog E (2001) Serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor in inflammatory arthritis. Arthritis Rheum 44:2055–2064CrossRefPubMed Ballara S, Taylor PC, Reusch P, Marme D, Maini RN, Paleolog E (2001) Serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor in inflammatory arthritis. Arthritis Rheum 44:2055–2064CrossRefPubMed
10.
go back to reference Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S, Ciolkiewicz M (2006) A study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis. Clin Rheumatol 25:314–319CrossRefPubMed Kuryliszyn-Moskal A, Klimiuk PA, Sierakowski S, Ciolkiewicz M (2006) A study on vascular endothelial growth factor and endothelin-1 in patients with extra-articular involvement of rheumatoid arthritis. Clin Rheumatol 25:314–319CrossRefPubMed
11.
go back to reference Cutolo M, Pizzorni C, Sulli A (2004) Nailfold video-capillaroscopy in systemic sclerosis. Z Rheumatol 63:457–462CrossRefPubMed Cutolo M, Pizzorni C, Sulli A (2004) Nailfold video-capillaroscopy in systemic sclerosis. Z Rheumatol 63:457–462CrossRefPubMed
12.
go back to reference Hachulla E, Perez-Cousin M, Flipo RM et al (1994) Increased capillary permeability in systemic rheumatoid vasculitis: detection by dynamic fluorescence nailfold videomicroscopy. J Rheumatol 21(7):1197–1202PubMed Hachulla E, Perez-Cousin M, Flipo RM et al (1994) Increased capillary permeability in systemic rheumatoid vasculitis: detection by dynamic fluorescence nailfold videomicroscopy. J Rheumatol 21(7):1197–1202PubMed
13.
go back to reference Corominas H, Ortiz-Santamaria V, Castellví I, Moreno M, Morlà R, Clavaguera T, Erra A, Martinez-Pardo S, Ordóñez S, Santo P, Reyner P, José González M, Codina O, Saul Gelman M, Juanola-Roura X, Olivé A, Torrente-Segarra V (2016) Capi CAT group. Nailfold capillaroscopic findings in primary Sjögren’s syndrome with and without Raynaud’s phenomenon and/or positive anti-SSA/Ro and anti-SSB/la antibodies. Rheumatol Int 36:365–369CrossRefPubMed Corominas H, Ortiz-Santamaria V, Castellví I, Moreno M, Morlà R, Clavaguera T, Erra A, Martinez-Pardo S, Ordóñez S, Santo P, Reyner P, José González M, Codina O, Saul Gelman M, Juanola-Roura X, Olivé A, Torrente-Segarra V (2016) Capi CAT group. Nailfold capillaroscopic findings in primary Sjögren’s syndrome with and without Raynaud’s phenomenon and/or positive anti-SSA/Ro and anti-SSB/la antibodies. Rheumatol Int 36:365–369CrossRefPubMed
14.
go back to reference Meyer MF, Schmidt O, Hellmich B, Schatz H, Klein HH, Braun J (2007) Microvascular dysfunction in rheumatoid arthritis assessed by laser Doppler anemometry: relationship to soluble adhesion molecules and extraarticular manifestations. Rheumatol Int 28(2):145–152CrossRefPubMed Meyer MF, Schmidt O, Hellmich B, Schatz H, Klein HH, Braun J (2007) Microvascular dysfunction in rheumatoid arthritis assessed by laser Doppler anemometry: relationship to soluble adhesion molecules and extraarticular manifestations. Rheumatol Int 28(2):145–152CrossRefPubMed
15.
go back to reference Klyscz T, Bogenschutz O, Junger M, Rassner G (1996) Microangiopathic changes and functional disorders of nail fold capillaries in dermatomyositis. Hautarzt 47:289–293CrossRefPubMed Klyscz T, Bogenschutz O, Junger M, Rassner G (1996) Microangiopathic changes and functional disorders of nail fold capillaries in dermatomyositis. Hautarzt 47:289–293CrossRefPubMed
16.
go back to reference Ingegnoli F, Zeni S, Meani L et al (2005) Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus. J Clin Rheumatol 11:295–298CrossRefPubMed Ingegnoli F, Zeni S, Meani L et al (2005) Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus. J Clin Rheumatol 11:295–298CrossRefPubMed
17.
go back to reference Riccieri V, Spadaro A, Ceccarelli F et al (2005) Nailfold capillaroscopy changes in systemic lupus erythematosus: correlations with disease activity and autoantibody profile. Lupus 14:521–525CrossRefPubMed Riccieri V, Spadaro A, Ceccarelli F et al (2005) Nailfold capillaroscopy changes in systemic lupus erythematosus: correlations with disease activity and autoantibody profile. Lupus 14:521–525CrossRefPubMed
18.
go back to reference Nagy Y, Czirjak L (2004) Nailfold digital capillaroscopy in 447 patients with connective tissue disease and Raynaud’s disease. J Eur Acad Dermatol Venereol 18:62–68CrossRefPubMed Nagy Y, Czirjak L (2004) Nailfold digital capillaroscopy in 447 patients with connective tissue disease and Raynaud’s disease. J Eur Acad Dermatol Venereol 18:62–68CrossRefPubMed
19.
go back to reference Altomonte L, Zoli A, Galossi A, Mirone L, Tulli A, Martone FR, Morini P, Laraia P, Magarò M (1995) Microvascular capillaroscopic abnormalities in rheumatoid arthritis patients. Clin Exp Rheumatol 13(1):83–86PubMed Altomonte L, Zoli A, Galossi A, Mirone L, Tulli A, Martone FR, Morini P, Laraia P, Magarò M (1995) Microvascular capillaroscopic abnormalities in rheumatoid arthritis patients. Clin Exp Rheumatol 13(1):83–86PubMed
20.
go back to reference Caspary L, Schmees C, Schoetensack I, Hartung K, Stannat S, Deicher H et al (1991) Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus. J Rheumatol 18:559–566PubMed Caspary L, Schmees C, Schoetensack I, Hartung K, Stannat S, Deicher H et al (1991) Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus. J Rheumatol 18:559–566PubMed
21.
go back to reference Lekakis J, Mavrikakis M, Emmanuel M, Prassopoulos V, Papazoglou S, Papamichael C, Moulopoulou D, Kostamis P, Stamatelopoulos S, Moulopoulos S (1998) Cold-induced coronary Raynaud’s phenomenon in patients with systemic sclerosis. Clin Exp Rheumatol 16(2):135–140PubMed Lekakis J, Mavrikakis M, Emmanuel M, Prassopoulos V, Papazoglou S, Papamichael C, Moulopoulou D, Kostamis P, Stamatelopoulos S, Moulopoulos S (1998) Cold-induced coronary Raynaud’s phenomenon in patients with systemic sclerosis. Clin Exp Rheumatol 16(2):135–140PubMed
22.
go back to reference Mathews JL, Ward JR, Samuelson CO, Knibbe WP (1983) Spontaneous nasal septal perforation in patients with rheumatoid arthritis. Clin Rheumatol 2(1):13–18CrossRefPubMed Mathews JL, Ward JR, Samuelson CO, Knibbe WP (1983) Spontaneous nasal septal perforation in patients with rheumatoid arthritis. Clin Rheumatol 2(1):13–18CrossRefPubMed
23.
go back to reference Mourao AF, Amaral M, Caetano-Lopes J, Isenberg D (2009) An analysis of joint replacement in patients with systemic lupus erythematosus. Lupus 18(14):1298–1302CrossRefPubMed Mourao AF, Amaral M, Caetano-Lopes J, Isenberg D (2009) An analysis of joint replacement in patients with systemic lupus erythematosus. Lupus 18(14):1298–1302CrossRefPubMed
Metadata
Title
Nailfold videocapillaroscopy results in patients with rheumatoid arthritis
Authors
Sinem Sag
Mustafa Serdar Sag
Ibrahim Tekeoglu
Ayhan Kamanli
Kemal Nas
Yıldıray Aydın
Publication date
01-09-2017
Publisher
Springer London
Published in
Clinical Rheumatology / Issue 9/2017
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-017-3696-4

Other articles of this Issue 9/2017

Clinical Rheumatology 9/2017 Go to the issue