Skip to main content
Top
Published in: Clinical Rheumatology 3/2013

01-03-2013 | Original Article

Clinical features of Kashin–Beck disease in adults younger than 50 years of age during a low incidence period: severe elbow and knee lesions

Authors: Yong Li, Zongke Zhou, Bin Shen, Jing Yang, Pengde Kang, Xiaobo Yang, Gang Liu, Fuxing Pei

Published in: Clinical Rheumatology | Issue 3/2013

Login to get access

Abstract

More than one million people are affected by Kashin–Beck disease (KBD) in a limited endemic area. However, few studies focused on the clinical features of adult KBD patients. The aim of this study was to investigate the clinical features of adult KBD patients who were younger than 50 years of age during a low incidence period. A special questionnaire was designed that surveyed general data, clinical symptoms, and signs and included the Visual Analogue Scale (VAS). Anthropometrics, the joint VAS, the range of joint motion (ROM), and joint function were measured. The VAS and joint dysfunction were compared among the different joints of extremities, and the relationship among the VAS, ROM, age, course of KBD, and number of enlarged knee and elbow joints elbow was analyzed. Two hundred forty-nine adult Tibetan KBD patients, matched with 249 healthy control subjects, have been surveyed. The VAS results show that the knee is the joint associated with the most pain, followed by the elbow. The elbow shows a higher percentage of limited ROM (47.0 %). The number of enlarged joints has a significant correlation with the VAS or elbow and knee ROM compared with the age or course of disease (P < 0.05). Severe elbow and knee lesions are important clinical features of KBD in adults younger than 50 years of age during a low incidence period. The number of enlarged joints can partially predict the VAS or ROM of elbow and knee and may be used for evaluating the patient’s condition and function.
Literature
1.
go back to reference Mathieu F, Begaux F, Suetens C et al (2001) Anthropometry and clinical features of Kashin–Beck disease in central Tibet. Int Orthop 25(3):138–141PubMedCrossRef Mathieu F, Begaux F, Suetens C et al (2001) Anthropometry and clinical features of Kashin–Beck disease in central Tibet. Int Orthop 25(3):138–141PubMedCrossRef
2.
go back to reference Moreno-Reyes R, Mathieu F, Boelaert M et al (2003) Selenium and iodine supplementation of rural Tibetan children affected by Kashin–Beck osteoarthropathy. Am J Clin Nutr 78:137–144PubMed Moreno-Reyes R, Mathieu F, Boelaert M et al (2003) Selenium and iodine supplementation of rural Tibetan children affected by Kashin–Beck osteoarthropathy. Am J Clin Nutr 78:137–144PubMed
3.
go back to reference Pasteels JL, Liu FD, Hinsenkamp M et al (2001) Histology of Kashin–Beck lesions. Int Orthop 25:151–153PubMedCrossRef Pasteels JL, Liu FD, Hinsenkamp M et al (2001) Histology of Kashin–Beck lesions. Int Orthop 25:151–153PubMedCrossRef
4.
go back to reference Wang LH, Fu Y, Shi YX et al (2011) T-2 toxin induces degenerative articular changes in rodents: link to Kaschin–Beck disease. Toxicol Pathol 39(3):502–507PubMedCrossRef Wang LH, Fu Y, Shi YX et al (2011) T-2 toxin induces degenerative articular changes in rodents: link to Kaschin–Beck disease. Toxicol Pathol 39(3):502–507PubMedCrossRef
5.
go back to reference Malaisse F, Mathieu F (2008) Big bone disease. A multidisciplinary approach of KBD in Tibet Autonomous Region (P.R. China). Les Presses Agronomiques de Gembloux, ASBL (Belgium) 15:70–78 Malaisse F, Mathieu F (2008) Big bone disease. A multidisciplinary approach of KBD in Tibet Autonomous Region (P.R. China). Les Presses Agronomiques de Gembloux, ASBL (Belgium) 15:70–78
6.
go back to reference Mathieu F, Begaux F, Lan ZY et al (1997) Clinical manifestations of Kashin–Beck disease in Nyemo Valley, Tibet. Int Orthop 21:151–156PubMedCrossRef Mathieu F, Begaux F, Lan ZY et al (1997) Clinical manifestations of Kashin–Beck disease in Nyemo Valley, Tibet. Int Orthop 21:151–156PubMedCrossRef
7.
go back to reference Chasseur C, Suetens C, Nolard N et al (1997) Fungal contamination in barley and Kashin–Beck disease in Tibet. Lancet 350:1074PubMedCrossRef Chasseur C, Suetens C, Nolard N et al (1997) Fungal contamination in barley and Kashin–Beck disease in Tibet. Lancet 350:1074PubMedCrossRef
8.
go back to reference Chasseur C, Suetens C, Michel V et al (2001) A 4-year study of the mycological aspects of Kashin–Beck disease in Tibet. Int Orthop 25:154–158PubMedCrossRef Chasseur C, Suetens C, Michel V et al (2001) A 4-year study of the mycological aspects of Kashin–Beck disease in Tibet. Int Orthop 25:154–158PubMedCrossRef
9.
go back to reference Haubruge E, Chasseur C, Debouck C (2001) The prevalence of mycotoxins in Kashin–Beck disease. Int Orthop 25:159–161PubMedCrossRef Haubruge E, Chasseur C, Debouck C (2001) The prevalence of mycotoxins in Kashin–Beck disease. Int Orthop 25:159–161PubMedCrossRef
10.
go back to reference Moreno-Reyes R, Suetens C, Mathieu F et al (1998) Kashin–Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339:1112–1120PubMedCrossRef Moreno-Reyes R, Suetens C, Mathieu F et al (1998) Kashin–Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. N Engl J Med 339:1112–1120PubMedCrossRef
11.
go back to reference La Grange M, Mathieu F, Begaux F et al (2001) Kashin–Beck disease and drinking water in Central Tibet. Int Orthop 25:167–169PubMedCrossRef La Grange M, Mathieu F, Begaux F et al (2001) Kashin–Beck disease and drinking water in Central Tibet. Int Orthop 25:167–169PubMedCrossRef
12.
go back to reference Schepman K, Engelbert RH, Visser MM et al (2011) Kashin Beck disease: more than just osteoarthrosis: a cross-sectional study regarding the influence of body function- structures and activities on level of participation. Int Orthop 35(5):767–776PubMedCrossRef Schepman K, Engelbert RH, Visser MM et al (2011) Kashin Beck disease: more than just osteoarthrosis: a cross-sectional study regarding the influence of body function- structures and activities on level of participation. Int Orthop 35(5):767–776PubMedCrossRef
13.
go back to reference Xiong G (2001) Diagnostic, clinical and radiological characteristics of Kashin–Beck disease in Shaanxi Province, PR China. Int Orthop 25(3):147–150PubMedCrossRef Xiong G (2001) Diagnostic, clinical and radiological characteristics of Kashin–Beck disease in Shaanxi Province, PR China. Int Orthop 25(3):147–150PubMedCrossRef
14.
go back to reference Yang J (2003) Signs and methods of observing the disease condition and treatment effects of adult Kashin–Beck disease. Chin J Endemiology 22(6):512–516 Yang J (2003) Signs and methods of observing the disease condition and treatment effects of adult Kashin–Beck disease. Chin J Endemiology 22(6):512–516
15.
go back to reference Bao W, Liu N, Gao B et al (2003) Survey of adult Kashin–Beck disease at Guanghui village. Chin J Endemiology 22(5):410–413 Bao W, Liu N, Gao B et al (2003) Survey of adult Kashin–Beck disease at Guanghui village. Chin J Endemiology 22(5):410–413
16.
go back to reference Mathieu F, Suetens C, Begaux F et al (2001) Effects of physical therapy on patients with Kashin–Beck disease in Tibet. Int Orthop 25:191–193PubMedCrossRef Mathieu F, Suetens C, Begaux F et al (2001) Effects of physical therapy on patients with Kashin–Beck disease in Tibet. Int Orthop 25:191–193PubMedCrossRef
17.
go back to reference Zhang W, Doherty M, Leeb BF et al (2009) EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. [Review]. Ann Rheum Dis 68(1):8–17PubMedCrossRef Zhang W, Doherty M, Leeb BF et al (2009) EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. [Review]. Ann Rheum Dis 68(1):8–17PubMedCrossRef
18.
go back to reference Wang Y, Yang Z, Gilula LA et al (1996) Kashin–Beck disease: radiographic appearance in the hands and wrists. Radiology 201:265–270PubMed Wang Y, Yang Z, Gilula LA et al (1996) Kashin–Beck disease: radiographic appearance in the hands and wrists. Radiology 201:265–270PubMed
19.
go back to reference Hinsenkamp M, Ryppens F, Begaux F et al (2001) The anatomical distribution of radiological abnormalities in Kashin–Beck disease in Tibet. Int Orthop 25(3):142–147PubMedCrossRef Hinsenkamp M, Ryppens F, Begaux F et al (2001) The anatomical distribution of radiological abnormalities in Kashin–Beck disease in Tibet. Int Orthop 25(3):142–147PubMedCrossRef
20.
21.
go back to reference Davies AP, Glasgow MM (2000) Imaging in osteoarthritis: a guide to requesting plain X-rays of the degenerate knee. Knee 7(3):139–143PubMedCrossRef Davies AP, Glasgow MM (2000) Imaging in osteoarthritis: a guide to requesting plain X-rays of the degenerate knee. Knee 7(3):139–143PubMedCrossRef
22.
go back to reference McDonough CM, Jette AM (2010) The contribution of osteoarthritis to functional limitations and disability. Clin Geriatr Med 26(3):387–399PubMedCrossRef McDonough CM, Jette AM (2010) The contribution of osteoarthritis to functional limitations and disability. Clin Geriatr Med 26(3):387–399PubMedCrossRef
Metadata
Title
Clinical features of Kashin–Beck disease in adults younger than 50 years of age during a low incidence period: severe elbow and knee lesions
Authors
Yong Li
Zongke Zhou
Bin Shen
Jing Yang
Pengde Kang
Xiaobo Yang
Gang Liu
Fuxing Pei
Publication date
01-03-2013
Publisher
Springer-Verlag
Published in
Clinical Rheumatology / Issue 3/2013
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-012-2115-0

Other articles of this Issue 3/2013

Clinical Rheumatology 3/2013 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.