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Open Access 01-10-2019 | Glioma | Review Article

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

Authors: Simone L. Schonkeren, Maartje Massen, Raisa van der Horst, Alexander Koch, Nathalie Vaes, Veerle Melotte

Published in: Neurogenetics | Issue 4/2019

Abstract

The N-Myc downstream-regulated gene (NDRG) family consists of four members (NDRG1, NDRG2, NDRG3, NDRG4) that are differentially expressed in various organs and function in important processes, like cell proliferation and differentiation. In the last couple of decades, interest in this family has risen due to its connection with several disorders of the nervous system including Charcot-Marie-Tooth disease and dementia, as well as nervous system cancers. By combining a literature review with in silico data analysis of publicly available datasets, such as the Mouse Brain Atlas, BrainSpan, the Genotype-Tissue Expression (GTEx) project, and Gene Expression Omnibus (GEO) datasets, this review summarizes the expression and functions of the NDRG family in the healthy and diseased nervous system. We here show that the NDRGs have a differential, relatively cell type–specific, expression pattern in the nervous system. Even though NDRGs share functionalities, like a role in vesicle trafficking, stress response, and neurite outgrowth, other functionalities seem to be unique to a specific member, e.g., the role of NDRG1 in myelination. Furthermore, mutations, phosphorylation, or changes in expression of NDRGs are related to nervous system diseases, including peripheral neuropathy and different forms of dementia. Moreover, NDRG1, NDRG2, and NDRG4 are all involved in cancers of the nervous system, such as glioma, neuroblastoma, or meningioma. All in all, our review elucidates that although the NDRGs belong to the same gene family and share some functional features, they should be considered unique in their expression patterns and functional importance for nervous system development and neuronal diseases.

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Title: Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system
Authors: Simone L. Schonkeren
Maartje Massen
Raisa van der Horst
Alexander Koch
Nathalie Vaes
Veerle Melotte
Publication date: 01-10-2019
Publisher: Springer Berlin Heidelberg
Keywords: Glioma
Meningioma
Neuroblastoma
Neuroblastoma
Glioma
Alzheimer's Disease
Dementia
Meningioma
Alzheimer's Disease
Glioma
Dementia
Published in: Neurogenetics / Issue 4/2019
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI: https://doi.org/10.1007/s10048-019-00587-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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