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Open Access 01-12-2020 | Incisional Hernia | Review

Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis

Authors: H. Liu, S. van Steensel, M. Gielen, T. Vercoulen, J. Melenhorst, B. Winkens, N. D. Bouvy

Published in: Hernia | Issue 6/2020

Abstract

Purpose

Laparoscopic intraperitoneal onlay mesh in hernia repair can result in adhesions leading to intestinal obstruction and fistulation. The aim of this systematic review is to compare the effects of mesh coatings reducing the tissue-to-mesh adhesion in animal studies.

Methods

Pubmed and Embase were systematically searched. Animal experiments comparing intraperitoneally placed meshes with coatings were eligible for inclusion. Only studies with comparable follow-up, measurements, and species were included for data pooling and subsequent meta-analysis.

Results

A total of 131 articles met inclusion criteria, with four studies integrated into one comparison and five studies integrated into another comparison. Compared to uncoated polypropylene (PP) mesh, PP mesh coated with hyaluronic acid/carboxymethyl cellulose (HA/CMC) showed significantly reduced adhesion formation at follow-up of 4 weeks measured with adhesion score of extent (random effects model, mean difference,− 0.96, 95% CI − 1.32 to − 0.61, P < 0.001, I² = 23%; fixed effects model, mean difference,− 0.94, 95% CI − 1.25 to − 0.63, P < 0.001, I² = 23%). Compared to PP mesh, polyester mesh coated with collagen (PC mesh) showed no significant difference at follow-up of 4 weeks regarding percentage of adhesion-area on a mesh, using random effects model (mean difference − 11.69, 95% CI − 44.14 to 20.76, P = 0.48, I² = 92%). However, this result differed using fixed effects model (mean difference − 25.55, 95% CI − 33.70 to − 7.40, P < 0.001, I² = 92%).

Conclusion

HA/CMC coating reduces adhesion formation to PP mesh effectively at a follow-up of 4 weeks, while the anti-adhesive properties of PC mesh are inclusive comparing all study data.

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Title: Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis
Authors: H. Liu
S. van Steensel
M. Gielen
T. Vercoulen
J. Melenhorst
B. Winkens
N. D. Bouvy
Publication date: 01-12-2020
Publisher: Springer Paris
Keyword: Incisional Hernia
Published in: Hernia / Issue 6/2020
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI: https://doi.org/10.1007/s10029-019-02071-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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