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Medical Molecular Morphology
Published in: Medical Molecular Morphology 4/2017

01-12-2017 | Original Paper

The significance of TIMD4 expression in clear cell renal cell carcinoma

Authors: Hiromu Yano, Takanobu Motoshima, Chaoya Ma, Cheng Pan, Sohsuke Yamada, Toshiyuki Nakayama, Shohei Kitada, Naohiro Fujimoto, Tomomi Kamba, Motohiro Takeya, Yoshihiro Komohara

Published in: Medical Molecular Morphology | Issue 4/2017

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Abstract

T-cell immunoglobulin and mucin domain (TIMD) family genes are related to innate immune responses. TIMD4 is a receptor for phosphatidylserine and is involved in the phagocytosis of apoptotic cells by macrophages. In the present study, we found that TIMD4 is expressed on the cancer cells of patients with clear cell renal cell carcinoma (ccRCC). TIMD4 was immunostained in the resected samples of 89 patients diagnosed as ccRCC. High expression of TIMD4 in cancer cells was closely related to short progression free survival time; however, it was not correlated with other clinicopathological factors. Intracellular expression of TIMD4 was observed in the RCC cell line, 786-O. In vitro studies using 786-O cells and shRNA targeting TIMD4 indicated that TIMD4 expression was associated with resistance to sorafenib but not with cell proliferation. TIMD4 might be useful as a prognostic factor and may also be a new target for therapy of ccRCC.
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Metadata
Title
The significance of TIMD4 expression in clear cell renal cell carcinoma
Authors
Hiromu Yano
Takanobu Motoshima
Chaoya Ma
Cheng Pan
Sohsuke Yamada
Toshiyuki Nakayama
Shohei Kitada
Naohiro Fujimoto
Tomomi Kamba
Motohiro Takeya
Yoshihiro Komohara
Publication date
01-12-2017
Publisher
Springer Japan
Published in
Medical Molecular Morphology / Issue 4/2017
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-017-0164-9

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