Top

Published in:

01-06-2014 | Award Review

Recent classification of renal epithelial tumors

Authors: Naoto Kuroda, Azusa Tanaka

Published in: Medical Molecular Morphology | Issue 2/2014

Abstract

The recent classification of renal tumors is based on genetic evidence as well as on histologic features. Malignant tumor includes clear cell renal carcinoma (RCC), multilocular cystic RCC, papillary RCC, chromophobe RCC, carcinoma of the collecting duct of Bellini, renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions and mucinous tubular and spindle cell carcinoma. Benign tumor is subdivided into papillary adenoma, renal oncocytoma and metanephric adenoma. Recently, new disease entities such as acquired cystic disease-associated RCC, clear cell papillary RCC and renal carcinoma with t(6;11)(p21:q12) have been discovered. In this article, we briefly review and introduce the clinical, morphological and genetic features of these tumor entities.

Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) (2004) World Health Organization Classification of Tumors. Pathology & Genetics. Tumours of the urinary system and male genital organ. IARC press, Lyon

Amin MB, McKenney JK, Tickoo SK, Paner GP, Shen SS, Velazquez EF, Cubilla AL, Ro JY, Reuter VE (eds) (2010) Diagnostic pathology, genitourinary. Amirsys, LWW, Canada

Shuin T, Kondo K, Torigoe S, Kishida T, Kubota Y, Hosaka M, Nagashima Y, Kitamura H, Latif F, Zbar B, Lerman MI, Yao M (1994) Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 54:2852–2855PubMed

Nagashima Y, Inayama Y, Kato Y, Kanno H, Aoki I, Yao M (2004) Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date. Pathol Int 54:377–386PubMedCrossRef

Sükösd F, Kuroda N, Beothe T, Kaur AP, Kovacs G (2003) Deletion of chromosome 3p14.2-p25 involving in the VHL and FHIT genes in conventional renal cell carcinoma. Cancer Res 63:455–457PubMed

Williamson SR, Halat S, Eble JN, Grignon DJ, Lopez-Beltran A, Montironi R, Tan P-H, Wang M, Zhang S, MacLennan GT, Baldridge LA, Cheng L (2012) Multilocular cystic renal cell carcinoma. Similarities and difference in immunoprofile compared with clear cell renal cell carcinoma. Am J Surg Pathol 36:1425–1433PubMedCrossRef

Kuroda N, Ohe C, Mikami S, Inoue K, Nagashima Y, Cohen RJ, Pan CC, Michal M, Hes O (2012) Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol 27:969–974PubMed

Delahunt B, Eble JN (1997) Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol 10:537–544PubMed

Kuroda N, Toi M, Hiroi M, Enzan H (2003) Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol 18:487–494PubMed

10.

Thoenes W, Störkel S, Rumplet H-J, Moll R, Baum HP, Werner S (1988) Chromophobe cell renal carcinoma and its variant—a report of 32 cases. J Pathol 155:277–287PubMedCrossRef

11.

Nagashima Y (2000) Chromophobe renal cell carcinoma: clinical, pathological and molecular biological aspects. Pathol Int 50:872–878PubMedCrossRef

12.

Kuroda N, Toi M, Hiroi M, Enzan H (2003) Review of chromophobe renal cell carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol 18:165–171PubMed

13.

Fleming S, Lewi HJE (1986) Collecting duct carcinoma of the kidney. Histopathology 10:1131–1141PubMedCrossRef

14.

Kobayashi N, Matsuzaki O, Shirai S, Aoki I, Yao M, Nagashima Y (2008) Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis. Hum Pathol 39:1350–1359PubMedCrossRef

15.

Kuroda N, Toi M, Hiroi M, Enzan H (2002) Review of collecting duct carcinoma with focus on clinical and pathobiological aspects. Histol Histopathol 17:1329–1334PubMed

16.

Armah HB, Parwani AV (2010) Xp11.2 translocation renal cell carcinoma. Arch Pathol Lab Med 134:124–129PubMed

17.

Kuroda N, Mikami S, Pan CC, Cohen RJ, Hes O, Michal M, Nagashima Y, Tanaka Y, Inoue K, Shuin T, Lee GH (2012) Review of renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions with focus on pathobiological aspect. Histol Histopathol 27:133–140PubMed

18.

Rakozy C, Schmahl GE, Bogner S, Störkel S (2002) Low-grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. Mod Pathol 15:1162–1171PubMedCrossRef

19.

Kuroda N, Toi M, Hiroi M, Suin T, Enzan H (2005) Review of mucinous tubular and spindle-cell carcinoma of the kidney with focus on clinical and pathobiological aspects. Histol Histopathol 20:221–224PubMed

20.

Amin MB, Crotty TB, Tickoo SK, Farrow GM (1997) Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol 21:1–12PubMedCrossRef

21.

Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin S, Reuter VE (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 21:871–883PubMedCrossRef

22.

Kuroda N, Toi M, Hiroi M, Shuin T, Enzan H (2003) Review of renal oncocytoma with focus on clinical and pathobiological aspects. Histol Histopathol 18:935–942PubMed

23.

Grignon DV, Eble JN (1998) Papillary and metanephric adenomas of the kidney. Semin Diagn Pathol 15:41–53PubMed

24.

Wade Strong J, Ro JY (1996) Metanephric adenoma of the kidney: a newly characterized entity. Adv Anat Pathol 3:172–178CrossRef

25.

Kuroda N, Toi M, Hiroi M, Enzan H (2003) Review of metanephric adenoma of the kidney with focus on clinical and pathobiological aspects. Histol Histopathol 18:253–257PubMed

26.

Sule N, Yakupoglu U, Shen SS, Krishnan B, Yang G, Lerner S, Sheikh-Hamad D, Troung LD (2005) Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive study. Am J Surg Pathol 29:443–451PubMedCrossRef

27.

Tickoo SK, dePeralta-Venturina MN, Harik LR, Worcester HD, Salama ME, Young AN, Moch H, Amin MB (2006) Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol 30:141–153PubMedCrossRef

28.

Kuroda N, Ohe C, Mikami S, Hes O, Michal M, Brunelli M, Martignoni G, Sato Y, Yoshino T, Kakehi Y, Shuin T, Lee GH (2011) Review of acquired cystic disease-associated renal cell carcinoma with focus on pathobiological aspects. Histol Histopathol 26:1215–1218PubMed

29.

Kuroda N, Tamura M, Taguchi T, Tominaga A, Hes O, Michal M, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Shuin T, Lee GH (2008) Sarcomatoid acquired cystic disease-associated renal cell carcinoma. Histol Histopathol 23:1327–1331PubMed

30.

Kuroda N, Tamura M, Hamaguchi N, Mikami S, Pan CC, Brunelli M, Martignoni G, Hes O, Michal M, Lee GH (2011) Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features. Ann Diagn Pathol 15:462–466PubMedCrossRef

31.

Ross H, Martignoni G, Argani P (2011) Renal cell carcinoma with clear cell and papillary features. Arch Pathol Lab Med 136:391–399CrossRef

32.

Kuroda N, Shiotsu T, Kawada C, Shuin T, Hes O, Michal M, Ohe C, Mikami S, Pan CC (2011) Clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma arising in acquired cystic disease of the kidney: an immunohistochemical and genetic study. Ann Diagn Pathol 15:282–285PubMedCrossRef

33.

Argani P, Hawkins A, Griffin CA, Goldstein JD, Haas M, Beckwith JB, Mankinen CB, Perlman EJ (2001) A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21;q12) chromosome translocation. Am J Pathol 158:2089–2096PubMedCentralPubMedCrossRef

34.

Argani P, Laé M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, Tomaszewski JE, Brooks JS, Acs G, Bridge JA, Vargas SO, Davis IJ, Fisher DE, Ladanyi M (2005) Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol 29:230–240PubMedCrossRef

35.

Petersson F, Vaněček T, Michal M, Martignoni G, Brunelli M, Halbhuber Z, Spagnolo D, Kuroda N, Yang XJ, Alvarado-Cabrero I, Hora M, Branžovský J, Trivunic S, Kacerovská D, Steiner P, Hes O (2012) A distinctive translocation of the kidney; “rosette forming”, t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases. Hum Pathol 43:726–736PubMedCrossRef

36.

Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, Bridge JA (2011) Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum. Mod Pathol 24:430–442PubMedCrossRef

37.

Mariño-Enríquez A, Ou W-B, Weldon CB, Fletcher JA, Pérez-Atayde AR (2011) ALK rearrangement in sickle cell trait-associated renal medullary carcinoma. Genes Chromosom Cancer 5:146–153CrossRef

38.

Sugawara E, Togashi Y, Kuroda N, Sakata S, Hatano S, Asaka R, Yuasa T, Yonese J, Kitagawa M, Mano H, Ishikawa Y, Takeuchi K (2012) Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method. Cancer 118:4427–4436PubMedCrossRef

39.

Sukov WR, Hodge JC, Lohse CM, Akre MK, Leibovich BC, Thompson RH, Cheville JC (2012) ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients. Mod Pathol 25:1516–1525PubMedCrossRef

Title: Recent classification of renal epithelial tumors
Authors: Naoto Kuroda
Azusa Tanaka
Publication date: 01-06-2014
Publisher: Springer Japan
Published in: Medical Molecular Morphology / Issue 2/2014
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI: https://doi.org/10.1007/s00795-013-0033-0

At a glance: The STEP trials

Springer Medicine

Recent classification of renal epithelial tumors

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2014

Aquaporin-1 is associated with arterial capillary proliferation and hepatic sinusoidal transformation contributing to portal hypertension in primary biliary cirrhosis

Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo

Characteristic patterns of maternal and fetal arterial construction in the rabbit placenta

Exceptionally large solitary fibrous tumor arising from the cheek: an immunohistochemical and ultrastructural study with a review of the literature

Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats

Invasion and metastasis of renal cell carcinoma