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Clinical Oral Investigations
Published in: Clinical Oral Investigations 6/2014

01-07-2014 | Original Article

Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis

Authors: Hui Wang, Qi Han, Zhenhua Luo, Caixia Xu, Jiajia Liu, Hongxia Dan, Yi Xu, Xin Zeng, Qianming Chen

Published in: Clinical Oral Investigations | Issue 6/2014

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Abstract

Objectives

This study aims to compare the expression levels of interleukin (IL)-17 and IL-23 in local periodontal tissues from patients with both chronic periodontitis and oral lichen planus (CP-OLP), patients with chronic periodontitis (CP) only, patients with oral lichen planus (OLP) only, and healthy controls (HC).

Materials and methods

The periodontal tissues were collected from 15 CP-OLP patients, 15 CP patients, 15 OLP patients, and 10 healthy controls. Immunohistochemistry (IHC) and real-time quantitative PCR (qPCR) was performed to investigate the protein and mRNA expression level of IL-17 and IL-23 in periodontal lesions from these four groups.

Results

IHC statistical analysis showed that the expression level of IL-17- and IL-23p19-positive cells significantly increased in CP-OLP group compared with that in CP (P < 0.01) and OLP groups (P < 0.05), showing intense staining reaction in local lamina propria lesions. Meanwhile, qPCR result showed higher IL-17 mRNA level in CP-OLP compared with that in CP and OLP groups and demonstrated a significant increase than OLP group (P < 0.05). Moreover, it was found that IL-17 mRNA expression level in erosive CP-OLP patients was significantly correlated with probing depth and attachment loss (P < 0.05).

Conclusions

This study indicated that there was an increased expression level of IL-17 and IL-23 in periodontal tissues from periodontitis patients with oral lichen planus, which might aggravate the inflammatory response in local lesions.

Clinical relevance

Oral lichen planus and chronic periodontitis may have interaction in disease pathogenesis, while IL-17 detection in local lesions may be helpful in identifying the disease severity in periodontitis patients with oral lichen planus.
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Metadata
Title
Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis
Authors
Hui Wang
Qi Han
Zhenhua Luo
Caixia Xu
Jiajia Liu
Hongxia Dan
Yi Xu
Xin Zeng
Qianming Chen
Publication date
01-07-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 6/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-013-1131-z

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