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Clinical Oral Investigations
Published in: Clinical Oral Investigations 6/2014

01-07-2014 | Original Article

Immunohistochemical characteristics of regenerated bone after surgical therapy of advanced ligature-induced peri-implantitis defects

Authors: Frank Schwarz, Ilja Mihatovic, Vladimir Golubovic, Jürgen Becker, Martin Sager

Published in: Clinical Oral Investigations | Issue 6/2014

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Abstract

Objectives

This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis.

Methods

At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equine bone block (EB) or implantoplasty. NBM and EB were soak-loaded with rhBMP-2 or sterile saline. Membrane (i.e., native collagen) protected sites were submerged for 12 weeks. Osteocalcin (OC) and transglutaminase 2 (TG2; angiogenesis) antigen reactivity was assessed within the augmented- (AA) and pristine bone (PB) areas at non-exposed sites (n = 39 defects).

Results

In all groups investigated, mean OC (AA, 0.5 ± 0.4 to 1.9 ± 2.9 %/PB, 1.7 ± 2.6 to 3.5 ± 6.5 %) and TG2 (AA, 0.6 ± 0.5 to 1.3 ± 1.5 %/PB, 0.5 ± 0.5 to 1.6 ± 1.9 %) values within AA did not significantly differ from those values assessed within PB (P > 0.05, respectively).

Conclusions

AA formed in different treatment groups may not be considered as qualitatively (i.e., OC and TG2) compromised bone.
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Metadata
Title
Immunohistochemical characteristics of regenerated bone after surgical therapy of advanced ligature-induced peri-implantitis defects
Authors
Frank Schwarz
Ilja Mihatovic
Vladimir Golubovic
Jürgen Becker
Martin Sager
Publication date
01-07-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 6/2014
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-013-1138-5

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