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01-11-2015 | Review Article

Bone-adiposity cross-talk: implications for pediatric obesity

A narrative review of literature

Authors: Elodie Chaplais, David Thivel, David Greene, Frederic Dutheil, Pascale Duche, Geraldine Naughton, Daniel Courteix

Published in: Journal of Bone and Mineral Metabolism | Issue 6/2015

Abstract

The rising prevalence of overweight and obesity among pediatric populations has become a major global concern. The objective of this review is to demonstrate potential interactions between the products released by fat tissue and the hormonal production of bone tissue in obese children and adolescents. Advancing the understanding of the complex interactions between adipocyte and osteocyte activities may contribute to the mechanistic understanding of the body’s responses to weight loss during adolescence. This knowledge could also reveal any side effects encountered with these interventions. Currently, the concept of bone-adiposity crosstalk has not been fully elucidated, and the mechanisms remain controversial. Understanding the local interactions between the released products by fat tissue and hormones produced in bone tissue requires further investigations.

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Title: Bone-adiposity cross-talk: implications for pediatric obesity
A narrative review of literature
Authors: Elodie Chaplais
David Thivel
David Greene
Frederic Dutheil
Pascale Duche
Geraldine Naughton
Daniel Courteix
Publication date: 01-11-2015
Publisher: Springer Japan
Published in: Journal of Bone and Mineral Metabolism / Issue 6/2015
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-015-0654-6

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