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Journal of Bone and Mineral Metabolism
Published in: Journal of Bone and Mineral Metabolism 5/2009

01-09-2009 | Original Article

Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents

Authors: Wagner Luiz do Prado, Aline de Piano, Marise Lazaretti-Castro, Marco Túlio de Mello, Sérgio Garcia Stella, Sergio Tufik, Cláudia Maria Oller do Nascimento, Lila Missae Oyama, Mara Cristina Lofrano, Lian Tock, Danielle Arisa Caranti, Ana Raimunda Dâmaso

Published in: Journal of Bone and Mineral Metabolism | Issue 5/2009

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Abstract

Despite the epidemic of adolescent obesity, the effect of obesity and hormones on bone mineral accrual during growth is poorly understood. Studies using dual-energy X-ray to examine the effect of obesity on bone mass in children and adolescents have yielded conflicting results. The aim of this study was to explore the combined and independent contributions of body mass index, body composition, leptin, insulin, glucose levels and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) to bone mineral density (BMD) and bone mineral content in a group of Brazilian obese adolescents. This study included 109 post-pubescent obese adolescents. A whole-body dual-energy X-ray absorptiometry scan was performed,using a HOLOGIC QDR4200, to determine whole-body BMD and body composition. Blood samples were collected in the outpatient clinic after an overnight fast, and evaluated for fasting blood glucose and immunoreactive insulin. Leptin levels were assessed with a radioimmunoassay kit. Insulin resistance was assessed by HOMA-IR and the quantitative insulin sensitivity check index. Our results showed that insulin levels and HOMA-IR correlated negatively with BMD and a linear regression analysis showed that serum leptin is inversely associated to BMD adjusted for body mass. In conclusion, our data support the hypothesis that leptin, insulin and HOMA-IR are inversely associated with BMD and play a significant direct role in bone metabolism.
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Metadata
Title
Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents
Authors
Wagner Luiz do Prado
Aline de Piano
Marise Lazaretti-Castro
Marco Túlio de Mello
Sérgio Garcia Stella
Sergio Tufik
Cláudia Maria Oller do Nascimento
Lila Missae Oyama
Mara Cristina Lofrano
Lian Tock
Danielle Arisa Caranti
Ana Raimunda Dâmaso
Publication date
01-09-2009
Publisher
Springer Japan
Published in
Journal of Bone and Mineral Metabolism / Issue 5/2009
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-009-0082-6

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