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01-06-2020 | Influenza Virus | Brief Report

Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes

Authors: Aizhan S. Turmagambetova, Madina S. Alexyuk, Andrey P. Bogoyavlenskiy, Pavel G. Alexyuk, Irina A. Zaitseva, Elmira S. Omirtaeva, Nadezhda S. Sokolova, Vladimir E. Berezin

Published in: Archives of Virology | Issue 6/2020

Abstract

The use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFNγ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines.

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Title: Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes
Authors: Aizhan S. Turmagambetova
Madina S. Alexyuk
Andrey P. Bogoyavlenskiy
Pavel G. Alexyuk
Irina A. Zaitseva
Elmira S. Omirtaeva
Nadezhda S. Sokolova
Vladimir E. Berezin
Publication date: 01-06-2020
Publisher: Springer Vienna
Keyword: Influenza Virus
Published in: Archives of Virology / Issue 6/2020
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-020-04619-1

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