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01-10-2019 | Hepatitis C | Brief Report

MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus

Authors: Thamiris Vaz Gago Prata, Dayane de Souza Rodrigues da Silva, Caroline Manchiero, Bianca Peixoto Dantas, Celso Carmo Mazza, Arielle Karen da Silva Nunes, Edson Abdala, Gerusa Maria Figueiredo, Fátima Mitiko Tengan, Mariana Cavalheiro Magri

Published in: Archives of Virology | Issue 10/2019

Abstract

Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis.

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Title: MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus
Authors: Thamiris Vaz Gago Prata
Dayane de Souza Rodrigues da Silva
Caroline Manchiero
Bianca Peixoto Dantas
Celso Carmo Mazza
Arielle Karen da Silva Nunes
Edson Abdala
Gerusa Maria Figueiredo
Fátima Mitiko Tengan
Mariana Cavalheiro Magri
Publication date: 01-10-2019
Publisher: Springer Vienna
Keyword: Hepatitis C
Published in: Archives of Virology / Issue 10/2019
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-019-04352-4

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