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01-09-2016 | Brief Report

Rabies vaccination at a virus-inoculated site as an alternative option to rabies immunoglobulin

Authors: Kinjiro Morimoto, Pakamatz Khawplod, Yuichiro Sato, Phatthamon Virojanapirom, Thiravat Hemachudha

Published in: Archives of Virology | Issue 9/2016

Abstract

Combined active and passive immunization has been established to be an optimal strategy for rabies post-exposure prophylaxis (PEP). Prompt administration of vaccine and rabies immunoglobulin (RIG) can reliably prevent the disease. However, RIG is unavailable and unaffordable in the majority of cases. On the basis of a model experiment using hamsters, we demonstrated that vaccine injection at the wound site in the same manner as administration of RIG provided protective efficacy that was not inferior to the current optimal PEP, a combination of vaccination and RIG. Further study is needed to determine whether it can replace the use of RIG.

World Health Organization (Geneva) (2013) WHO expert consultation on rabies. WHO Technical Report Series 982

Müller T, Dietzschold B, Ertl H, Fooks AR, Freuling C, Fehlner-Gardiner C, Kliemt J, Meslin FX, Franka R, Rupprecht CE, Tordo N, Wanderler AI, Kieny MP (2009) Development of a mouse monoclonal antibody cocktail for post-exposure rabies prophylaxis in humans. PLoS Negl Trop Dis 3(11):e542. doi:10.1371/journal.pntd.0000542 CrossRefPubMedPubMedCentral

Wilde H, Tipkong P, Khawplod P (1999) Economic issue in post-exposure rabies treatment. J Travel Med 6(4):238–242CrossRefPubMed

Wilde H, Lumlertdacha B, Meslin FX, Ghai S, Hemachudha T (2015) Worldwide rabies deaths prevention-A focus on the current inadequacies in postexposure prophylaxis of animal bite victims. Vaccine 34(2):187–189. doi:10.1016/j.vaccine.2015.11.036 CrossRefPubMed

Chutivongse S, Wilde H, Supich C, Baer GM, Fishbein DB (1990) Postexposure prophylaxis for rabies with antiserum and intradermal vaccination. Lancet 335(8694):896–898CrossRefPubMed

Saraya A, Wacharapluesadee S, Khawplod P, Tepsumethanon S, Briggs D, Asawavichienjinda T, Hemachudha T (2010) A preliminary study of chemo- and cytokine responses in rabies vaccine recipients of intradermal and intramuscular regimens. Vaccine 28(29):4553–4557CrossRefPubMed

Virojanapirom P, Khawplod P, Sawangvaree A, Wacharapluesadee S, Hemachudha T, Yamada K, Morimoto K, Nishizono A (2012) Molecular analysis of the mutational effects of Thai street rabies virus with increased virulence in mice after passages in the BHK cell line. Arch Virol 157(11):2201–2205. doi:10.1007/s00705-012-1402-z CrossRefPubMed

Smith JS, Yager PA, Baer GM (1996) A rapid fluorescent focus inhibition test (RFFIT) for determining rabies virus-neutralising antibody. In: Meslin FX, Kaplan MM, Koprowski H (eds) Laboratory techniques in rabies, 4th edn. World Health Organization, Geneva, pp 181–192

Tantawichien T, Benjavongkulchai M, Limsuwan K, Khawplod P, Kaewchompoo W, Chomchey P, Sitprija V (1999) Antibody response after a four-site intradermal booster vaccination with cell-culture rabies vaccine. Clin Infect Dis 28(5):1100–1103CrossRefPubMed

10.

World Health Organization (Geneva) Rabies vaccines WHO position paper (2007) Weekly Epidemiological Record No. 49/50, pp 425–436

11.

Sarmento L, Li XQ, Howerth E, Jackson AC, Fu ZF (2005) Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the central nervous system of mice. J Neurovirol 11(6):571–581CrossRefPubMed

12.

Li J, McGettigan JP, Faber M, Schnell MJ, Dietzschold B (2008) Infection of monocytes or immature dendritic cells (DCs) with an attenuated rabies virus results in DC maturation and a strong activation of the NFκB signaling pathway. Vaccine 26(3):419–426CrossRefPubMed

13.

Kuang Y, Lackay SN, Zhao L, Fu ZF (2009) Role of chemokines in the enhancement of BBB permeability and inflammatory infiltration after rabies virus infection. Virus Res 144(1–2):18–26. doi:10.1016/j.virusres.2009.03.014 CrossRefPubMedPubMedCentral

14.

Lafon M (2011) Evasive strategies in rabies virus infection. Adv Virus Res 79:33–53. doi:10.1016/B978-0-12-387040-7.00003-2 CrossRefPubMed

15.

Menager P, Roux P, Megret F, Bourgeois JP, Le Sourd AM, Danckaert A, Lafage M, Prehaud C, Lafon M (2009) Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. PLoS Pathog 5(2):e1000315. doi:10.1371/journal.ppat.1000315 CrossRefPubMedPubMedCentral

16.

Brzozka K, Finke S, Conzelmann KK (2005) Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3. J Virol 79(12):7673–7681. doi:10.1128/JVI.79.12.7673-7681.2005 CrossRefPubMedPubMedCentral

17.

Brzozka K, Finke S, Conzelmann KK (2006) Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2. J Virol 80(6):2675–2683. doi:10.1128/JVI.80.6.2675-2683.2006 CrossRefPubMed

18.

Rieder M, Conzelmann KK (2011) Interferon in rabies virus infection. Adv Virus Res 79:91–114. doi:10.1016/B978-0-12-387040-7.00006-8 CrossRefPubMed

19.

Vidy A, Chelbi-Alix M, Blondel D (2005) Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways. J Virol 79(22):14411–14420. doi:10.1128/JVI.79.22.14411-14420.2005 CrossRefPubMedPubMedCentral

20.

Vidy A, El Bougrini J, Chelbi-Alix MK, Blondel D (2007) The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1. J Virol 81(8):4255–4263. doi:10.1128/JVI.01930-06 CrossRefPubMedPubMedCentral

21.

Moseley GW, Lahaye X, Roth DM, Oksayan S, Filmer RP, Rowe CL, Blondel D, Jans DA (2009) Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response. J Cell Sci 122:3652–3662. doi:10.1242/jcs.045542 CrossRefPubMed

22.

Chopy D, Pothlichet J, Lafage M, Megret F, Fiette L, Si-Tahar M, Lafon M (2011) Ambivalent role of the innate immune response in rabies virus pathogenesis. J Virol 85(13):6657–6668. doi:10.1128/JVI.00302-11 CrossRefPubMedPubMedCentral

23.

Miller A, Morse HC 3rd, Winkelstein J, Nathanson N (1978) The role of antibody in recovery from experimental rabies. I. Effect of depletion of B and T cells. J Immunol 121(1):321–326PubMed

24.

Templeton JW, Holmberg C, Garber T, Sharp RM (1986) Genetic control of serum neutralizing-antibody response to rabies vaccination and survival after a rabies challenge infection in mice. J Virol 59(1):98–102PubMedPubMedCentral

25.

Xiang ZQ, Knowles BB, McCarrick JW, Ertl HC (1995) Immune effector mechanisms required for protection to rabies virus. Virology 214(2):398–404CrossRefPubMed

26.

Servat A, Lutsch C, Delore V, Lang J, Veitch K, Cliquet F (2003) Efficacy of rabies immunoglobulins in an experimental post-exposure prophylaxis rodent model. Vaccine 22(2):244–249CrossRefPubMed

27.

Dorfmeier CL, Tzvetkov EP, Gatt A, McGettigan JP (2013) Investigating the role for IL-21 in rabies virus vaccine-induced immunity. PLoS Negl Trop Dis 7(3):e2129. doi:10.1371/journal.pntd.0002129 CrossRefPubMedPubMedCentral

28.

Zhou M, Zhang G, Ren G, Gnanadurai CW, Li Z, Chai Q, Yang Y, Leyson CM, Wu W, Cui M, Fu ZF (2013) Recombinant rabies viruses expressing GM-CSF or flagellin are effective vaccines for both intramuscular and oral immunizations. PLoS One 8(5):e63384. doi:10.1371/journal.pone.0063384 CrossRefPubMedPubMedCentral

Title: Rabies vaccination at a virus-inoculated site as an alternative option to rabies immunoglobulin
Authors: Kinjiro Morimoto
Pakamatz Khawplod
Yuichiro Sato
Phatthamon Virojanapirom
Thiravat Hemachudha
Publication date: 01-09-2016
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 9/2016
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-016-2916-6

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