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01-02-2016 | Brief Report

A new genotype of border disease virus with implications for molecular diagnostics

Authors: Simone Peletto, Claudio Caruso, Francesco Cerutti, Paola Modesto, Simona Zoppi, Alessandro Dondo, Pier Luigi Acutis, Loretta Masoero

Published in: Archives of Virology | Issue 2/2016

Abstract

Border disease virus (BDV) is a (+) single-stranded RNA pestivirus affecting mainly sheep and goats worldwide. Genetic typing of BDV has led to the identification of at least seven major genotypes. This study reports the detection of a BDV strain from a goat in northwestern Italy during routine investigations. Sequence analysis revealed mutations in the 5’-UTR of the virus with implications for BDV molecular diagnostics. Moreover, subsequent phylogenetic analysis based on the combined 5’-UTR and Npro/partial C genes, showed divergence from known BDV genotypes, revealing the detection of a novel pestivirus group, for which we propose the name BDV genotype 8.

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Title: A new genotype of border disease virus with implications for molecular diagnostics
Authors: Simone Peletto
Claudio Caruso
Francesco Cerutti
Paola Modesto
Simona Zoppi
Alessandro Dondo
Pier Luigi Acutis
Loretta Masoero
Publication date: 01-02-2016
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 2/2016
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-015-2696-4

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