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Archives of Virology
Published in: Archives of Virology 11/2013

01-11-2013 | Brief Report

Whole-genome sequence analysis of a Korean G11P[25] rotavirus strain identifies several porcine-human reassortant events

Authors: Van Thai Than, Jong-Hwa Park, In Sik Chung, Jong Bum Kim, Wonyong Kim

Published in: Archives of Virology | Issue 11/2013

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Abstract

A rare rotavirus, RVA/Human-wt/KOR/CAU12-2/2012/G11P[25], was isolated from a 16-year-old female with fever and diarrhea during the 2012 rotavirus surveillance in South Korea using a cell culture system, and its full genome sequence was determined and analyzed. Strain CAU12-2 exhibited a G11-P[25]-I12-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analysis of this strain revealed that it is a human-porcine reassortant of two distant relatives of the G11 strains circulating in the world. The VP7 and VP4 genes are most closely related to those of human G11P[25] viruses (Dhaka6, KTM368, and N-38 strains) identified in South Asia, whereas the VP1 gene originated from a porcine G11P[7] virus (YM strain) that was identified in South America. The VP6 gene was found to belong to the new genotype I12. This study indicates that the G11-P[25]-I12 genotype was introduced into the South Korean population by interspecies transmissions of human and animal rotaviruses, followed by multiple reassortment events.
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Metadata
Title
Whole-genome sequence analysis of a Korean G11P[25] rotavirus strain identifies several porcine-human reassortant events
Authors
Van Thai Than
Jong-Hwa Park
In Sik Chung
Jong Bum Kim
Wonyong Kim
Publication date
01-11-2013
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 11/2013
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-013-1720-9

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