Top

Published in:

Open Access 01-03-2013 | Brief Review

Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics

Authors: Boris Klempa, Tatjana Avsic-Zupanc, Jan Clement, Tamara K. Dzagurova, Heikki Henttonen, Paul Heyman, Ferenc Jakab, Detlev H. Kruger, Piet Maes, Anna Papa, Evgeniy A. Tkachenko, Rainer G. Ulrich, Olli Vapalahti, Antti Vaheri

Published in: Archives of Virology | Issue 3/2013

Abstract

Dobrava-Belgrade virus (DOBV) is a human pathogen that has evolved in, and is hosted by, mice of several species of the genus Apodemus. We propose a subdivision of the species Dobrava-Belgrade virus into four related genotypes – Dobrava, Kurkino, Saaremaa, and Sochi – that show characteristic differences in their phylogeny, specific host reservoirs, geographical distribution, and pathogenicity for humans.

Antoniadis A, Stylianakis A, Papa A, Alexiou-Daniel S, Lampropoulos A, Nichol ST, Peters CJ, Spiropoulou CF (1996) Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome. J Infect Dis 174:407–410PubMedCrossRef

Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (1992) Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia. J Med Virol 38:132–137PubMedCrossRef

Avsic-Zupanc T, Toney A, Anderson K, Chu YK, Schmaljohn C (1995) Genetic and antigenic properties of Dobrava virus: a unique member of the Hantavirus genus, family Bunyaviridae. J Gen Virol 76:2801–2808PubMedCrossRef

Avsic-Zupanc T, Petrovec M, Furlan P, Kaps R, Elgh F, Lundkvist A (1999) Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia–a 10-year survey. Clin Infect Dis 28:860–865PubMedCrossRef

Avsic-Zupanc T, Nemirov K, Petrovec M, Trilar T, Poljak M, Vaheri A, Plyusnin A (2000) Genetic analysis of wild-type Dobrava hantavirus in Slovenia: co-existence of two distinct genetic lineages within the same natural focus. J Gen Virol 81:1747–1755PubMed

Blasdell K, Henttonen H, Buchy P (2011) Hantavirus genetic diversity. In: Morand S, Beaudeau F, Cabaret S (eds) New frontiers of molecular epidemiology of infectious diseases, 1st edn. Springer, Berlin, pp 179–216

Boeskorov G, Kartavtseva I, Zagorodniuk I, Belianin A, Liapunova EA (1995) Nucleolus organizer regions and B-chromosomes of wood mice (Mammalia, Rodentia, Apodemus) [in Russian]. Genetika 31:185–192PubMed

Dzagurova TK, Klempa B, Tkachenko EA, Slyusareva GP, Morozov VG, Auste B, Kruger DH (2009) Molecular diagnostics of hemorrhagic fever with renal syndrome during a Dobrava virus infection outbreak in the European part of Russia. J Clin Microbiol 47:4029–4036PubMedCrossRef

Dzagurova TK, Witkowski PT, Tkachenko EA, Klempa B, Morozov VG, Auste B, Zavora DL, Iunicheva IV, Mutnih ES, Kruger DH (2012) Isolation of Sochi virus from a fatal case of hantavirus disease with fulminant clinical course. Clin Infect Dis 54:e1–e4PubMedCrossRef

10.

Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA (2005) Virus taxonomy. Eighth report of the International Committee on Taxonomy of Viruses. Elsevier Academic Press, Amsterdam

11.

Gligic A, Dimkovic N, Xiao SY, Buckle GJ, Jovanovic D, Velimirovic D, Stojanovic R, Obradovic M, Diglisic G, Micic J, Asher DM, LeDuc JW, Yanagihara R, Gajdusek DC (1992) Belgrade virus: a new hantavirus causing severe hemorrhagic fever with renal syndrome in Yugoslavia. J Infect Dis 166:113–120PubMedCrossRef

12.

Golovljova I, Sjölander KB, Lindegren G, Vene S, Vasilenko V, Plyusnin A, Lundkvist A (2002) Hantaviruses in Estonia. J Med Virol 68:589–598PubMedCrossRef

13.

Golovljova I, Vasilenko V, Mittzenkov V, Prükk T, Seppet E, Vene S, Settergren B, Plyusnin A, Lundkvist A (2007) Characterization of hemorrhagic fever with renal syndrome caused by hantaviruses, Estonia. Emerg Infect Dis 13:1773–1776PubMedCrossRef

14.

Henttonen H, Buchy P, Suputtamongkol Y, Jittapalapong S, Herbreteau V, Laakkonen J, Chaval Y, Galan M, Dobigny G, Charbonnel N, Michaux J, Cosson JF, Morand S, Hugot JP (2008) Recent discoveries of new hantaviruses widen their range and question their origins. Ann NY Acad Sci 1149:84–89PubMedCrossRef

15.

Hjelle B, Yates T (2001) Modeling hantavirus maintenance and transmission in rodent communities. Curr Top Microbiol Immunol 256:77–90PubMedCrossRef

16.

Jakab F, Horváth G, Ferenczi E, Sebok J, Varecza Z, Szucs G (2007) Detection of Dobrava hantaviruses in Apodemus agrarius mice in the Transdanubian region of Hungary. Virus Res 128:149–152PubMedCrossRef

17.

Jakab F, Sebok J, Ferenczi E, Horváth G, Szucs G (2007) First detection of Dobrava hantavirus from a patient with severe haemorrhagic fever with renal syndrome by SYBR Green-based real time RT-PCR. Scand J Infect Dis 39:902–906PubMedCrossRef

18.

Jonsson CB, Figueiredo LT, Vapalahti O (2010) A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev 23:412–441PubMedCrossRef

19.

Khaiboullina SF, Morzunov SP, St Jeor SC (2005) Hantaviruses: molecular biology, evolution and pathogenesis. Curr Mol Med 5:773–790PubMedCrossRef

20.

Kirsanovs S, Klempa B, Franke R, Lee MH, Schönrich G, Rang A, Kruger DH (2010) Genetic reassortment between high-virulent and low-virulent Dobrava-Belgrade virus strains. Virus Genes 41:319–328PubMedCrossRef

21.

Klempa B, Schmidt HA, Ulrich R, Kaluz S, Labuda M, Meisel H, Hjelle B, Kruger DH (2003) Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature. J Virol 77:804–809PubMedCrossRef

22.

Klempa B, Ulrich R, Meisel H, Krüger DH, Schmidt HA, Kaluz S, Labuda M, Hjelle B (2003) Genetic interaction between Dobrava and Saaremaa hantaviruses: Now or millions of years ago? (Authors’ Reply). J Virol 77:7157–7158CrossRef

23.

Klempa B, Schütt M, Auste B, Labuda M, Ulrich R, Meisel H, Krüger DH (2004) First molecular identification of human Dobrava virus infection in central Europe. J Clin Microbiol 42:1322–1325PubMedCrossRef

24.

Klempa B, Stanko M, Labuda M, Ulrich R, Meisel H, Krüger DH (2005) Central European Dobrava Hantavirus isolate from a striped field mouse (Apodemus agrarius). J Clin Microbiol 43:2756–2763PubMedCrossRef

25.

Klempa B, Fichet-Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H, Denys C, Koivogui L, ter Meulen J, Krüger DH (2006) Hantavirus in African wood mouse, Guinea. Emerg Infect Dis 12:838–840PubMedCrossRef

26.

Klempa B, Meisel H, Kruger DH, Ulrich R, Stanko M, Labuda M (2006) Saaremaa hantavirus should not be confused with its dangerous relative, Dobrava virus – Author’s reply. J Clin Microbiol 44:1609–1611

27.

Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YV, Morozov VG, Okulova NM, Slyusareva GP, Smirnov A, Kruger DH (2008) Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerg Infect Dis 14:617–625PubMedCrossRef

28.

Klempa B, Witkowski PT, Popugaeva E, Auste B, Koivogui L, Fichet-Calvet E, Strecker T, Ter Meulen J, Krüger DH (2012) Sangassou virus, the first hantavirus isolate from Africa, displays genetic and functional properties distinct from those of other Murinae-associated hantaviruses. J Virol 86:3819–3827PubMedCrossRef

29.

Klingström J, Hardestam J, Lundkvist A (2006) Dobrava, but not Saaremaa, hantavirus is lethal and induces nitric oxide production in suckling mice. Microbes Infect 8:728–737PubMedCrossRef

30.

Kruger DH, Klempa B (2011) Dobrava-Belgrade virus. In: Liu D (ed) Molecular detection of human viral pathogens. CRC Press, Boca Raton, London, New York, pp 631–638

31.

Lee HW, Baek LJ, Johnson KM (1982) Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J Infect Dis 146:638–644PubMedCrossRef

32.

Liu PQ, Liao HX, Fu JL, Hang CS, Song G (1984) Isolation of epidemic hemorrhagic fever virus from Rattus losea and Rattus confucianus and their antigenic identification. Bull Jiangxi Med Coll 3:1–7

33.

Lundkvist A, Apekina N, Myasnikov Y, Vapalahti O, Vaheri A, Plyusnin A (1997) Dobrava hantavirus outbreak in Russia. Lancet 350:781–782PubMedCrossRef

34.

Lundkvist A, Hukic M, Horling J, Gilljam M, Nichol S, Niklasson B (1997) Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Hercegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. J Med Virol 53:51–59PubMedCrossRef

35.

Lundkvist Å, Vasilenko V, Golovljova I, Plyusnin A, Vaheri A (1998) Human Dobrava hantavirus infections in Estonia. Lancet 352:369PubMedCrossRef

36.

Maes P, Klempa B, Clement J, Matthijnssens J, Gajdusek DC, Krüger DH, Van Ranst M (2009) A proposal for new criteria for the classification of hantaviruses, based on S and M segment protein sequences. Infect Genet Evol 9:813–820PubMedCrossRef

37.

Markotić A, Nichol ST, Kuzman I, Sanchez AJ, Ksiazek TG, Gagro A, Rabatić S, Zgorelec R, Avsic-Zupanc T, Beus I, Dekaris D (2002) Characteristics of Puumala and Dobrava infections in Croatia. J Med Virol 66:542–551PubMedCrossRef

38.

Meisel H, Lundkvist Å, Gantzer K, Bär W, Sibold C, Krüger DH (1998) First case of infection with hantavirus Dobrava in Germany. Eur J Clin Microbiol Infect Dis 17:884–885PubMedCrossRef

39.

Mentel R, Bordihn N, Wegner U, Wendel H, Niklasson B (1999) Hantavirus Dobrava infection with pulmonary manifestation. Med Microbiol Immunol 188:51–53PubMedCrossRef

40.

Németh V, Madai M, Maráczi A, Bérczi B, Horváth G, Oldal M, Kisfali P, Bányai K, Jakab F (2011) Detection of Dobrava-Belgrade hantavirus using recombinant-nucleocapsid-based enzyme-linked immunosorbent assay and SYBR Green-based real-time reverse transcriptase-polymerase chain reaction. Arch Virol 156:1655–1660PubMedCrossRef

41.

Nemirov K, Vapalahti O, Lundkvist A, Vasilenko V, Golovljova I, Plyusnina A, Niemimaa J, Laakkonen J, Henttonen H, Vaheri A, Plyusnin A (1999) Isolation and characterization of Dobrava hantavirus carried by the striped field mouse (Apodemus agrarius) in Estonia. J Gen Virol 80:371–379PubMed

42.

Nemirov K, Henttonen H, Vaheri A, Plyusnin A (2002) Phylogenetic evidence for host switching in the evolution of hantaviruses carried by Apodemus mice. Virus Res 90:207–215PubMedCrossRef

43.

Nemirov K, Vapalahti O, Papa A, Plyusnina A, Lundkvist A, Antoniadis A, Vaheri A, Plyusnin A (2003) Genetic characterization of new Dobrava hantavirus isolate from Greece. J Med Virol 69:408–416PubMedCrossRef

44.

Nemirov K, Andersen HK, Leirs H, Henttonen H, Vaheri A, Lundkvist A, Plyusnin A (2004) Saaremaa hantavirus in Denmark. J Clin Virol 30:254–257PubMedCrossRef

45.

Olsson GE, Leirs H, Henttonen H (2010) Hantaviruses and their hosts in Europe: reservoirs here and there, but not everywhere? Vector-Borne Zoon Dis 10:546–561CrossRef

46.

Oncul O, Atalay Y, Onem Y, Turhan V, Acar A, Uyar Y, Caglayik DY, Ozkan S, Gorenek L (2011) Hantavirus infection in Istanbul, Turkey. Emerg Infect Dis 17:303–304PubMedCrossRef

47.

Papa A, Johnson AM, Stockton PC, Bowen MD, Spiropoulou CF, Alexiou-Daniel S, Ksiazek TG, Nichol ST, Antoniadis A (1998) Retrospective serological and genetic study of the distribution of hantaviruses in Greece. J Med Virol 55:321–327PubMedCrossRef

48.

Papa A, Spiropoulou C, Nichol S, Antoniadis A (2000) Tracing Dobrava hantavirus infection. J Infect Dis 181:2116–2117PubMedCrossRef

49.

Papa A, Antoniadis A (2001) Hantavirus infections in Greece–an update. Eur J Epidemiol 17:189–194PubMedCrossRef

50.

Papa A, Nemirov K, Henttonen H, Niemimaa J, Antoniadis A, Vaheri A, Plyusnin A, Vapalahti O (2001) Isolation of Dobrava virus from Apodemus flavicollis in Greece. J Clin Microbiol 39:2291–2293PubMedCrossRef

51.

Papa A, Bojovic B, Antoniadis A (2006) Hantaviruses in Serbia and Montenegro. Emerg Infect Dis 12:1015–1018PubMedCrossRef

52.

Papa A, Zelená H, Barnetová D, Petrousová L (2010) Genetic detection of Dobrava/Belgrade virus in a Czech patient with Haemorrhagic fever with renal syndrome. Clin Microbiol Infect 16:1187–1190PubMedCrossRef

53.

Papa A, Christova I (2011) Genetic detection of Dobrava/Belgrade virus, Bulgaria. Emerg Infect Dis 17:308–309PubMedCrossRef

54.

Plyusnin A, Vapalahti O, Lankinen H, Lehvaslaiho H, Apekina N, Myasnikov Y, Kallio-Kokko H, Henttonen H, Lundkvist A, Brummer-Korvenkontio M, Gavrilovskaya I, Vaheri A (1994) Tula virus - a newly detected hantavirus carried by European common voles. J Virol 68:7833–7839PubMed

55.

Plyusnin A, Vapalahti O, Vasilenko V, Henttonen H, Vaheri A (1997) Dobrava hantavirus in Estonia: does the virus exist throughout Europe? Lancet 349:1369–1370PubMedCrossRef

56.

Plyusnin A, Nemirov K, Apekina N, Plyusnina A, Lundkvist Å, Vaheri A (1999) Dobrava hantavirus in Russia. Lancet 353:207PubMedCrossRef

57.

Plyusnin A (2002) Genetics of hantaviruses: implications to taxonomy. Arch Virol 147:665–682PubMedCrossRef

58.

Plyusnin A, Vaheri A, Lundkvist Å (2003) Genetic interaction between Dobrava and Saaremaa viruses: now or millions of years ago? J Virol 77:7156–7157PubMedCrossRef

59.

Plyusnin A, Vaheri A, Lundkvist A (2006) Saaremaa hantavirus should not be confused with its dangerous relative, Dobrava virus. J Clin Microbiol 44:1608–1609PubMedCrossRef

60.

Plyusnina A, Laakkonen J, Niemimaa J, Henttonen H, Plyusnin A (2008) New genetic lineage of Tula Hantavirus in Microtus arvalis obscurus in Eastern Kazakhstan. Open Virol J 2:32–36PubMedCrossRef

61.

Plyusnina A, Ferenczi E, Rácz GR, Nemirov K, Lundkvist A, Vaheri A, Vapalahti O, Plyusnin A (2009) Co-circulation of three pathogenic hantaviruses: Puumala, Dobrava, and Saaremaa in Hungary. J Med Virol 81:2045–2052PubMedCrossRef

62.

Plyusnina A, Krajinović LC, Margaletić J, Niemimaa J, Nemirov K, Lundkvist Å, Markotić A, Miletić-Medved M, Avšič-Županc T, Henttonen H, Plyusnin A (2011) Genetic evidence for the presence of two distinct hantaviruses associated with Apodemus mice in Croatia and analysis of local strains. J Med Virol 83:108–114PubMedCrossRef

63.

Popugaeva E, Witkowski PT, Schlegel M, Ulrich RG, Auste B, Rang A, Krüger DH, Klempa B (2012) Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE 7:e35587PubMedCrossRef

64.

Sarıgüzel N, Hofmann J, Canpolat AT, Türk A, Ettinger J, Atmaca D, Akyar I, Yücel S, Arıkan E, Uyar Y, Cağlayık DY, Kocagöz AS, Kaya A, Kruger DH (2012) Dobrava hantavirus infection complicated by panhypopituitarism, Istanbul, Turkey, 2010. Emerg Infect Dis 18:1180–1183PubMedCrossRef

65.

Scharninghausen JJ, Meyer H, Pfeffer M, Davis DS, Honeycutt RL (1999) Genetic evidence of Dobrava virus in Apodemus agrarius in Hungary. Emerg Infect Dis 5:468–470PubMedCrossRef

66.

Schlegel M, Klempa B, Auste B, Bemmann M, Schmidt-Chanasit J, Büchner T, Groschup MH, Meier M, Buschmann A, Zoller H, Krüger DH, Ulrich RG (2009) Multiple Dobrava-Belgrade virus spillover infections, Germany. Emerg Infect Dis 15:2017–2020PubMedCrossRef

67.

Schlegel M, Kindler E, Essbauer SS, Wolf R, Thiel J, Groschup MH, Heckel G, Oehme RM, Ulrich RG (2012) Tula virus infections in the Eurasian water vole in Central Europe. Vector Borne Zoonotic Dis 12:503–513PubMedCrossRef

68.

Schmidt-Chanasit J, Essbauer S, Petraityte R, Yoshimatsu K, Tackmann K, Conraths FJ, Sasnauskas K, Arikawa J, Thomas A, Pfeffer M, Scharninghausen JJ, Splettstoesser W, Wenk M, Heckel G, Ulrich RG (2010) Extensive host sharing of central European Tula virus. J Virol 84:459–474PubMedCrossRef

69.

Schütt M, Gerke P, Meisel H, Ulrich R, Kruger DH (2001) Clinical characterization of Dobrava hantavirus infections in Germany. Clin Nephrol 55:371–374PubMed

70.

Schütt M, Meisel H, Kruger DH, Ulrich R, Dalhoff K, Dodt C (2004) Life-threatening Dobrava hantavirus infection with unusually extended pulmonary involvement. Clin Nephrol 62:54–57PubMed

71.

Sibold C, Sparr S, Schulz A, Labuda M, Kozuch O, Lysy J, Kruger DH, Meisel H (1995) Genetic characterization of a new hantavirus detected in Microtus arvalis from Slovakia. Virus Genes 10:277–281PubMedCrossRef

72.

Sibold C, Meisel H, Lundkvist Å, Schulz A, Cifire F, Ulrich R, Kozuch O, Labuda M, Kruger DH (1999) Simultaneous occurrence of Dobrava, Puumala, and Tula hantaviruses in Slovakia. Am J Trop Med Hyg 61:409–411PubMed

73.

Sibold C, Ulrich R, Labuda M, Lundkvist Å, Martens H, Schütt M, Gerke P, Leitmeyer K, Meisel H, Kruger DH (2001) Dobrava hantavirus causes hemorrhagic fever with renal syndrome in central Europe and is carried by two different Apodemus mice species. J Med Virol 63:158–167PubMedCrossRef

74.

Sironen T, Vaheri A, Plyusnin A (2005) Phylogenetic evidence for the distinction of Saaremaa and Dobrava hantaviruses. Virol J 2:90PubMedCrossRef

75.

Sjolander KB, Golovljova I, Vasilenko V, Plyusnin A, Lundkvist Å (2002) Serological divergence of Dobrava and Saaremaa hantaviruses: evidence for two distinct serotypes. Epidemiol Infect 128:99–103PubMed

76.

Sumibcay L, Kadjo B, Gu SH, Kang HJ, Lim BK, Cook JA, Song JW, Yanagihara R (2012) Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d’Ivoire. Virol J 9:34PubMedCrossRef

77.

Taller AM, Xiao SY, Godec MS, Gligic A, Avsic-Zupanc T, Goldfarb LG, Yanagihara R, Asher DM (1993) Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice. J Infect Dis 168:750–753PubMedCrossRef

78.

Tamura K, Peterson D, Peterson N, Stecher G, Nie M, Kumar S (2011) MEGA5: Molecular evolutionary genetics analysis using maximum Likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731–2739PubMedCrossRef

79.

Tkachenko EA, Okulova NM, Iunicheva IuV, Morzunov SP, Khaĭbulina SF, Riabova TE, Vasilenko LE, Bashkirtsev VN, Dzagurova TK, Gorbachkova EA, Sedova NS, Balakirev AE, Dekonenko AE, Drozdov SG (2005) The epizootological and virological characteristics of a natural hantavirus infection focus in the subtropic zone of the Krasnodarsk Territory [in Rusian]. Vopr Virusol 50:14–19PubMed

80.

Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T, Vapalahti O (2012) Hantavirus infections in Europe and their impact on public health. Rev Med Virol. doi:10.1002/rmv.1722 PubMed

81.

Weidmann M, Schmidt P, Vackova M, Krivanec K, Munclinger P, Hufert FT (2005) Identification of genetic evidence for Dobrava virus spillover in rodents by nested reverse transcription (RT)-PCR and TaqMan RT-PCR. J Clin Microbiol 43:808–812PubMedCrossRef

82.

Weiss S, Witkowski P, Auste B, Nowak K, Weber N, Fahr J, Mombouli JV, Wolfe ND, Drexler JF, Drosten C, Klempa B, Leendertz FH, Kruger DH (2012) Hantavirus in bat, Sierra Leone. Emerg Infect Dis 18:159–161PubMedCrossRef

83.

Zelena H, Zvolankova V, Zuchnicka J, Liszkova K, Papa A (2011) Hantavirus infection during a stay in a mountain hut in Northern Slovakia. J Med Virol 83:496–500PubMedCrossRef

Title: Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics
Authors: Boris Klempa
Tatjana Avsic-Zupanc
Jan Clement
Tamara K. Dzagurova
Heikki Henttonen
Paul Heyman
Ferenc Jakab
Detlev H. Kruger
Piet Maes
Anna Papa
Evgeniy A. Tkachenko
Rainer G. Ulrich
Olli Vapalahti
Antti Vaheri
Publication date: 01-03-2013
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 3/2013
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-012-1514-5

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2013

Genotypic characterization of dengue virus strains circulating during 2007-2009 in New Delhi

Ancient RNA? RT-PCR of 50-year-old RNA identifies peach latent mosaic viroid

Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy

Host range and genetic diversity of croton yellow vein mosaic virus, a weed-infecting monopartite begomovirus causing leaf curl disease in tomato

Characterization of the recent outbreak of foot-and-mouth disease virus serotype SAT2 in Egypt

Characterization and whole genome sequences of the Rhodococcus bacteriophages RGL3 and RER2

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

Highlights from the ACC 2024 Congress

ACC 2024 Congress Coverage