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01-09-2011 | Original Article

Epidemiological and clinical characteristics of pediatric gastroenteritis associated with new viral agents

Authors: Sara Giordana Rimoldi, Fabrizio Stefani, Cristina Pagani, Lisa Lucia Chenal, Nadia Zanchetta, Ilaria Di Bartolo, Alessandra Lombardi, Franco Maria Ruggeri, Dario Di lillo, Gian Vincenzo Zuccotti, Maria Rita Gismondo

Published in: Archives of Virology | Issue 9/2011

Abstract

A 22-month study (2008-2009) was carried out on 273 patients (average age 40 months), admitted with gastroenteritis to the Pediatric Unit of L. Sacco University Hospital in Milan, Italy. Fecal samples were investigated for rotavirus (HRV), norovirus (NoV), adenovirus (AdV), sapovirus (SaV), enterovirus, astrovirus and bocavirus (HBoV). A 38.3% incidence of infection was observed for HRV, followed by NoV (16.2%), HBoV (13.6%), AdV (2.6%) and SaV (0.6%). Clinical evaluation of 109 gastroenteritis patients with confirmed diagnosis was graded by the Ruska-Vesikari scoring system, showing vomiting (78%), diarrhea (96%) and fever (80%). A total of 25 NoV-positive samples were selected for nucleotide sequence analysis. The severity of AdV-associated infection was lower than for NoV, HRV and HBoV. These latter viruses caused similar symptoms that were indistinguishable using clinical information. NoV, HRV and HBoV were often present as mixed infections (13.1%). Sequencing of NoV-positive samples allowed identification of GII.2, GII.3 and GII.4 2006 variants.

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Title: Epidemiological and clinical characteristics of pediatric gastroenteritis associated with new viral agents
Authors: Sara Giordana Rimoldi
Fabrizio Stefani
Cristina Pagani
Lisa Lucia Chenal
Nadia Zanchetta
Ilaria Di Bartolo
Alessandra Lombardi
Franco Maria Ruggeri
Dario Di lillo
Gian Vincenzo Zuccotti
Maria Rita Gismondo
Publication date: 01-09-2011
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 9/2011
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-011-1037-5

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