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01-08-2008 | Brief Review

Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?

Author: Joachim Denner

Published in: Archives of Virology | Issue 8/2008

Abstract

PERVs are integrated in the genome of all pigs. Some of them infect human cells and represent therefore a potential risk for xenotransplantation using pig cells or organs. Three replication-competent subtypes have been described, PERV-A, PERV-B and PERV-C. Whereas PERV-A and PERV-B are polytropic viruses and infect, among others, human cells, PERV-C is an ecotropic virus, infecting only pig cells. Recombinant PERV-A/C are able to infect human cells, they are characterised by high-titre replication and their proviruses have been found de novo integrated in the genome of somatic pig cells, but not in the germ line. This review compares recombinant PERVs with other recombinant retroviruses in order to evaluate their potential pathogenicity.

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Title: Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?
Author: Joachim Denner
Publication date: 01-08-2008
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 8/2008
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-008-0141-7

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