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Open Access 01-12-2006 | Short report

Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine

Authors: Stanley I Martin, Robert Wilkinson, Jay A Fishman

Published in: Virology Journal | Issue 1/2006

Abstract

The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo.

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Title: Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
Authors: Stanley I Martin
Robert Wilkinson
Jay A Fishman
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: Virology Journal / Issue 1/2006
Electronic ISSN: 1743-422X
DOI: https://doi.org/10.1186/1743-422X-3-91

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