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Open Access 01-12-2019 | Schizophrenia | Psychiatry and Preclinical Psychiatric Studies - Original Article

Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies

Authors: Stephen J. Kaar, Ilinca Angelescu, Tiago Reis Marques, Oliver D. Howes

Published in: Journal of Neural Transmission | Issue 12/2019

Abstract

Parvalbumin interneurons are fast-spiking GABAergic neurons that provide inhibitory control of cortical and subcortical circuits and are thought to be a key locus of the pathophysiology underlying schizophrenia. In view of the contradictory results regarding the nature of parvalbumin post-mortem findings in schizophrenia, we conducted a quantitative meta-analysis of the data on parvalbumin cell density and parvalbumin mRNA levels in pre-frontal regions in the brains of patients with schizophrenia (n = 274) compared with healthy controls (n = 275). The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges’ g = − 0.27; p = 0.03) and there is a non-significant reduction in parvalbumin mRNA levels (g = − 0.44; p = 0.12). However, certain methodological issues need to be considered in interpreting such results and are discussed in more detail. A meta-regression was conducted for post-mortem interval and year of publication as covariates which were both non-significant, except in the mRNA meta-analysis where post-mortem interval was found to be significant. Overall our findings provide tentative support for the hypothesis that the GABAergic system is deficient in schizophrenia and that parvalbumin-containing interneurons offer a potential target for treatment. However, further well-controlled studies that examine multiple regions and layers are warranted to determine whether parvalbumin alterations are region or layer specific and to test the robustness of the findings further.

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Title: Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies
Authors: Stephen J. Kaar
Ilinca Angelescu
Tiago Reis Marques
Oliver D. Howes
Publication date: 01-12-2019
Publisher: Springer Vienna
Keywords: Schizophrenia
Suicide
Suicide
Published in: Journal of Neural Transmission / Issue 12/2019
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-019-02080-2

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Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies

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