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01-11-2011 | Original Paper

Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

Authors: Alice Y. Wang, Kathryn M. Lohmann, C. Kevin Yang, Eric I. Zimmerman, Harry Pantazopoulos, Nicole Herring, Sabina Berretta, Stephan Heckers, Christine Konradi

Published in: Acta Neuropathologica | Issue 5/2011

Abstract

GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.

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Title: Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region
Authors: Alice Y. Wang
Kathryn M. Lohmann
C. Kevin Yang
Eric I. Zimmerman
Harry Pantazopoulos
Nicole Herring
Sabina Berretta
Stephan Heckers
Christine Konradi
Publication date: 01-11-2011
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 5/2011
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-011-0881-4

At a glance: The STEP trials

Springer Medicine

Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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