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01-09-2013 | Psychiatry and Preclinical Psychiatric Studies - Review article

Tracking cerebral white matter changes across the lifespan: insights from diffusion tensor imaging studies

Authors: Qian Jun Yap, Irvin Teh, Paolo Fusar-Poli, Min Yi Sum, Carissa Kuswanto, Kang Sim

Published in: Journal of Neural Transmission | Issue 9/2013

Abstract

Delineating the normal development of brain white matter (WM) over the human lifespan is crucial to improved understanding of underlying WM pathology in neuropsychiatric and neurological conditions. We review the extant literature concerning diffusion tensor imaging studies of brain WM development in healthy individuals available until October 2012, summarise trends of normal development of human brain WM and suggest possible future research directions. Temporally, brain WM maturation follows a curvilinear pattern with an increase in fractional anisotropy (FA) from newborn to adolescence, decelerating in adulthood till a plateau around mid-adulthood, and a more rapid decrease of FA from old age onwards. Spatially, brain WM tracts develop from central to peripheral regions, with evidence of anterior-to-posterior maturation in commissural and projection fibres. The corpus callosum and fornix develop first and decline earlier, whilst fronto-temporal WM tracts like cingulum and uncinate fasciculus have protracted maturation and decline later. Prefrontal WM is most vulnerable with greater age-related FA reduction compared with posterior WM. Future large scale studies adopting longitudinal design will better clarify human brain WM changes over time.

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Title: Tracking cerebral white matter changes across the lifespan: insights from diffusion tensor imaging studies
Authors: Qian Jun Yap
Irvin Teh
Paolo Fusar-Poli
Min Yi Sum
Carissa Kuswanto
Kang Sim
Publication date: 01-09-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-0971-7

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Tracking cerebral white matter changes across the lifespan: insights from diffusion tensor imaging studies

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