Editorial

Excerpt

Far from the original concept that the central nervous system (CNS) is immunologically privileged, growing evidences suggests that the brain and immune system are intricately connected and engaged in significant crosstalk to maintain homeostasis. It is therefore not surprising that activation of various component of the immune system is invariably observed during CNS injury and is now recognized as a prominent and common feature of many neurological disorders. Yet, the outcome of altered or dysfunctional immune system on pathogenesis is hardly predictable as both neuroprotective and neurodestructive outcomes have been attributed to immune activation. …