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01-08-2010 | Basic Neurosciences, Genetics and Immunology - Review Article

Inflammation in neuroviral diseases

Authors: Pascale Giraudon, Arlette Bernard

Published in: Journal of Neural Transmission | Issue 8/2010

Abstract

During any viral infection of the central nervous system (CNS), the extent and nature of neural cell alterations are dictated by the localization of virus replication and, possibly, persistence. However, one additional source of CNS damage comes from the immune response that develops following CNS viral infection. Indeed, despite of its major role in controlling virus spread in the infected CNS, the immune system is equipped with numerous molecular effectors shared with the nervous system that may greatly alter the homeostasis and function of neural cells. Proinflammatory cytokines and metalloproteases belong to this inflammatory cascade. Besides neurovirulence, the crosstalk engaged between neural and immune cells is a major factor determining the outcome of neuroviral infections.

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Title: Inflammation in neuroviral diseases
Authors: Pascale Giraudon
Arlette Bernard
Publication date: 01-08-2010
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 8/2010
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-010-0402-y

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Inflammation in neuroviral diseases

Abstract

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