Skip to main content
Top
Published in: Surgery Today 2/2021

01-02-2021 | Gastrectomy | Original Article

The safety and feasibility of laparoscopic gastrectomy for gastric cancer in very elderly patients: short-and long-term outcomes

Authors: Ryuichi Mikami, Eiji Tanaka, Teppei Murakami, Satoshi Ishida, Yugo Matsui, Kenta Horita, Masaki Yamada, Takashi Nitta, Masahiro Mise, Takehisa Harada, Masahiko Takeo, Shigeki Arii

Published in: Surgery Today | Issue 2/2021

Login to get access

Abstract

Purpose

It remains unclear whether laparoscopic gastrectomy (LG) for gastric cancer is a suitable treatment for very elderly (VE) patients. We aimed to assess the safety and feasibility of LG for gastric cancer in VE patients.

Methods

We reviewed 226 consecutive patients who underwent LG between January 2010 and December 2016. We compared VE patients (age ≥ 80, n = 38) with non-elderly patients (age ≤ 79, n = 188).

Results

An ASA-PS score ≥ 2 was more common in VE group (86.8 vs. 48.9%; P < 0.01). There were no significant differences in the operating time, blood loss, postoperative hospital stay, or postoperative morbidity between the groups. The 3-year survival rate and 3-year disease-specific survival rate were lower in the VE group (53.7 vs. 85.6%; P < 0.0001, 78.5 vs. 92.4%; P = 0.0116). A univariate analysis showed that PS scores ≥ 2, Charlson comorbidity index ≥ 4, and pN stage were independent predictors of decreased overall survival rates in the VE group. A multivariate analysis showed total gastrectomy, a Charlson comorbidity index ≥ 4, and the pN stage to be independent predictors in the VE group.

Conclusion

LG for gastric cancer is, thus, considered to be safe for patients aged 80 years or older. Total gastrectomy, a Charlson comorbidity index ≥ 4, and the pN stage were independent risk factors for a poor prognosis in these patients.
Appendix
Available only for authorised users
Literature
2.
go back to reference Kitano S, Iso Y, Moriyama M, Sugimachi K. Laproscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc. 1994;4:146–8.PubMed Kitano S, Iso Y, Moriyama M, Sugimachi K. Laproscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc. 1994;4:146–8.PubMed
3.
go back to reference Kim HH, Hyung WJ, Cho GS, Kim MC, Han SU, Kim W, et al. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report-a phase III multicenter, prospective, randomized Trial(KLASS Trial). Ann Surg. 2010;251:417–20.CrossRef Kim HH, Hyung WJ, Cho GS, Kim MC, Han SU, Kim W, et al. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report-a phase III multicenter, prospective, randomized Trial(KLASS Trial). Ann Surg. 2010;251:417–20.CrossRef
4.
go back to reference Vinuela EF, Gonen M, Brennan MF, Coit DG, Strong VE. Laparscopic versus open gastrectomy for gastric cancer, a meta-analysis of randomized controlled trials and high-quality nonrandomized studies. Ann Surg. 2012;255:446–56.CrossRef Vinuela EF, Gonen M, Brennan MF, Coit DG, Strong VE. Laparscopic versus open gastrectomy for gastric cancer, a meta-analysis of randomized controlled trials and high-quality nonrandomized studies. Ann Surg. 2012;255:446–56.CrossRef
6.
go back to reference Hu Y, Huang C, Sun Y, Su X, Cao H, Hu J, et al. Morbidity and mortality of laparoscopic versus open D2 distal gastrectomy for advanced gastric cancer: a randomized controlled trial. J Clin Oncol. 2016;34:1350–7.CrossRef Hu Y, Huang C, Sun Y, Su X, Cao H, Hu J, et al. Morbidity and mortality of laparoscopic versus open D2 distal gastrectomy for advanced gastric cancer: a randomized controlled trial. J Clin Oncol. 2016;34:1350–7.CrossRef
7.
go back to reference Mohri Y, Yasuda H, Ohi M, Tanaka K, Saigusa S, Okigami M, et al. Short-and long-term outcomes of laparoscopic gastrectomy in elderly patients with gastric cancer. Surg Endosc. 2015;29:1627–35.CrossRef Mohri Y, Yasuda H, Ohi M, Tanaka K, Saigusa S, Okigami M, et al. Short-and long-term outcomes of laparoscopic gastrectomy in elderly patients with gastric cancer. Surg Endosc. 2015;29:1627–35.CrossRef
8.
go back to reference Shimoda S, Sawada N, Oae S, Seki J, Takano Y, Ishiyama Y, et al. Safety and curability of laparoscopic gastrectomy in elderly patients with gastric cancer. Surg Endosc. 2018;32:4277–83.CrossRef Shimoda S, Sawada N, Oae S, Seki J, Takano Y, Ishiyama Y, et al. Safety and curability of laparoscopic gastrectomy in elderly patients with gastric cancer. Surg Endosc. 2018;32:4277–83.CrossRef
9.
go back to reference Aratani K, Sakuramoto S, Chuman M, Kasuya M, Wakata M, Miyawaki Y, et al. Laparoscopy-assisted distal gastrectomy for gastric cancer in elderly patients: surgical outcomes and prognosis. Antica Res. 2018;38:1721–5. Aratani K, Sakuramoto S, Chuman M, Kasuya M, Wakata M, Miyawaki Y, et al. Laparoscopy-assisted distal gastrectomy for gastric cancer in elderly patients: surgical outcomes and prognosis. Antica Res. 2018;38:1721–5.
10.
go back to reference Yang XY, Zhu SH, Li PZ, Li WZ, Sun XL. Outcomes of laparoscopic gastrectomy for gastric cancer in elderly patients. JBUON. 2018;23:85–91.PubMed Yang XY, Zhu SH, Li PZ, Li WZ, Sun XL. Outcomes of laparoscopic gastrectomy for gastric cancer in elderly patients. JBUON. 2018;23:85–91.PubMed
11.
go back to reference Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma. Gastric Cancer. 2011;14:101–12 (3rd English edition).CrossRef Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma. Gastric Cancer. 2011;14:101–12 (3rd English edition).CrossRef
12.
go back to reference Dindo D, Demartines N, Clavien P. Classification of surgical complications. A new proposal with evaluation in a cohort of 6336 patients and results of survey. Ann Surg. 2004;240:205–13.CrossRef Dindo D, Demartines N, Clavien P. Classification of surgical complications. A new proposal with evaluation in a cohort of 6336 patients and results of survey. Ann Surg. 2004;240:205–13.CrossRef
13.
go back to reference Kitano S, Shiraishi N, Fujiki K, Yasuda K, Inomata M, Adachi Y. A randomized controlled trial comparing open versus laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer:an interim report. Surgery. 2002;131(1 Suppl):306–11.CrossRef Kitano S, Shiraishi N, Fujiki K, Yasuda K, Inomata M, Adachi Y. A randomized controlled trial comparing open versus laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer:an interim report. Surgery. 2002;131(1 Suppl):306–11.CrossRef
14.
go back to reference Mochiki E, Nakabayashi T, Kamimura H, Haga N, Asao T, Kuwano H. Gastrointestinal recovery and outcome after laparoscopy-assisted versus conventional open distal gastrectomy for early gastric cancer. World J Surg. 2002;26:1145–9.CrossRef Mochiki E, Nakabayashi T, Kamimura H, Haga N, Asao T, Kuwano H. Gastrointestinal recovery and outcome after laparoscopy-assisted versus conventional open distal gastrectomy for early gastric cancer. World J Surg. 2002;26:1145–9.CrossRef
15.
go back to reference Huscher CG, Mingoli A, Sgarzini G, Sansonetti A, Di Paola M, Recher A, et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg. 2005;241:232–7.CrossRef Huscher CG, Mingoli A, Sgarzini G, Sansonetti A, Di Paola M, Recher A, et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Ann Surg. 2005;241:232–7.CrossRef
16.
go back to reference Kitano S, Shiraishi N, Uyama I, Sugihara K, Tanigawa N, Japanese Laparoscopic Surgery Study Group. A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan. Ann Surg. 2007;245:68–72.CrossRef Kitano S, Shiraishi N, Uyama I, Sugihara K, Tanigawa N, Japanese Laparoscopic Surgery Study Group. A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan. Ann Surg. 2007;245:68–72.CrossRef
17.
go back to reference Kim MC, Jung GJ, Kim HH. Morbidity and mortality of laparoscopy-assisted gastrectomy with extraperigastric lymph node dissection for gastric cancer. Dig Dis Sci. 2007;52:543–8.CrossRef Kim MC, Jung GJ, Kim HH. Morbidity and mortality of laparoscopy-assisted gastrectomy with extraperigastric lymph node dissection for gastric cancer. Dig Dis Sci. 2007;52:543–8.CrossRef
18.
go back to reference Kim MC, Kim W, Kim HH, Ryu SW, Ryu SW, Song KY, Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) Group. Risk factors associated with complication following laparoscopy-assisted gastrectomy for gastric cancer: a large-scale korean multicenter study. Ann Surg Oncol. 2008;15:2692–700.CrossRef Kim MC, Kim W, Kim HH, Ryu SW, Ryu SW, Song KY, Korean Laparoscopic Gastrointestinal Surgery Study (KLASS) Group. Risk factors associated with complication following laparoscopy-assisted gastrectomy for gastric cancer: a large-scale korean multicenter study. Ann Surg Oncol. 2008;15:2692–700.CrossRef
19.
go back to reference Lee JH, Yom CK, Han HS. Comparison of long-term outcomes of laparoscopy-assisted and open distal gastrectomy for early gastric cancer. Surg Endosc. 2009;23:1759–63.CrossRef Lee JH, Yom CK, Han HS. Comparison of long-term outcomes of laparoscopy-assisted and open distal gastrectomy for early gastric cancer. Surg Endosc. 2009;23:1759–63.CrossRef
20.
go back to reference Katai H, Mizusawa J, Katayama H, Takagi M, Yoshikawa T, Fukagawa T, et al. Short-term surgical outcomes from a phase III study of laparoscopy-assisted versus open distal gastrectomy with nodal dissection for clinical stage IA/IB gastric cancer: Japan Clinical Oncology Group Study JCOG0912. Gastric Cancer. 2017;20:699–708.CrossRef Katai H, Mizusawa J, Katayama H, Takagi M, Yoshikawa T, Fukagawa T, et al. Short-term surgical outcomes from a phase III study of laparoscopy-assisted versus open distal gastrectomy with nodal dissection for clinical stage IA/IB gastric cancer: Japan Clinical Oncology Group Study JCOG0912. Gastric Cancer. 2017;20:699–708.CrossRef
21.
go back to reference Hiki N, Katai H, Mizusawa J, Nakamura K, Nakamori M, Yoshikawa T, Stomach Cancer Study Group of Japan Clinical Oncology Group. Long-term outcomes of laparoscopic -assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: multicenter phase II trial (JCOG0703). Gastric Cancer. 2018;21:155–61.CrossRef Hiki N, Katai H, Mizusawa J, Nakamura K, Nakamori M, Yoshikawa T, Stomach Cancer Study Group of Japan Clinical Oncology Group. Long-term outcomes of laparoscopic -assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: multicenter phase II trial (JCOG0703). Gastric Cancer. 2018;21:155–61.CrossRef
22.
go back to reference Li Z, Li B, Bai B, Yu P, Lian B, Zhao Q. Long-term outcomes of laparoscopic versus open D2 gastrectomy for advanced gastric cancer. Surg Oncol. 2018;27:441–8.CrossRef Li Z, Li B, Bai B, Yu P, Lian B, Zhao Q. Long-term outcomes of laparoscopic versus open D2 gastrectomy for advanced gastric cancer. Surg Oncol. 2018;27:441–8.CrossRef
23.
go back to reference Inaki N, Etoh T, Ohyama T, Uchiyama K, Katada N, Koeda K, et al. A multi-institutional, prospective phase II feasibility study of laparoscopy-assisted distal gastrectomy with D2 lymph node dissection for locally advanced gastric cancer(JLSSG0901). World J Surg. 2015;39:2734–41.CrossRef Inaki N, Etoh T, Ohyama T, Uchiyama K, Katada N, Koeda K, et al. A multi-institutional, prospective phase II feasibility study of laparoscopy-assisted distal gastrectomy with D2 lymph node dissection for locally advanced gastric cancer(JLSSG0901). World J Surg. 2015;39:2734–41.CrossRef
24.
go back to reference Evers EM, Townsend CM Jr, Thompson JC. Organ physiology of aging. Surg Clin North Am. 1994;74:23–39.CrossRef Evers EM, Townsend CM Jr, Thompson JC. Organ physiology of aging. Surg Clin North Am. 1994;74:23–39.CrossRef
25.
go back to reference Jeon SH, Ahn HS, Yoo MW, Cho JJ, Lee HJ, Kim HH, et al. Increased morbidity rates in patients with heart disease or chronic liver disease following radical gastric surgery. Ann Surg Oncol. 2010;101:200–4.CrossRef Jeon SH, Ahn HS, Yoo MW, Cho JJ, Lee HJ, Kim HH, et al. Increased morbidity rates in patients with heart disease or chronic liver disease following radical gastric surgery. Ann Surg Oncol. 2010;101:200–4.CrossRef
26.
go back to reference Tsuchiya N, Kunisaki C, Makino H, Kimura J, Takagawa R, Sato S, et al. Feasibility of laparoscopy-assisited gastrectomy for gastric cancer in elderly patients: a case-control study. Surg Laparosc Endosc Percutan Tech. 2018;28:102–7.PubMed Tsuchiya N, Kunisaki C, Makino H, Kimura J, Takagawa R, Sato S, et al. Feasibility of laparoscopy-assisited gastrectomy for gastric cancer in elderly patients: a case-control study. Surg Laparosc Endosc Percutan Tech. 2018;28:102–7.PubMed
27.
go back to reference Yoshida M, Koga S, Ishimaru K, Yamamoto Y, Matsuo Y, Akita S, et al. Laparoscopy-assisted distal gastrectomy is feasible also for elderly patients aged 80 years and over: effectiveness and long-term prognosis. Surg Endosc. 2017;31:4431–7.CrossRef Yoshida M, Koga S, Ishimaru K, Yamamoto Y, Matsuo Y, Akita S, et al. Laparoscopy-assisted distal gastrectomy is feasible also for elderly patients aged 80 years and over: effectiveness and long-term prognosis. Surg Endosc. 2017;31:4431–7.CrossRef
28.
go back to reference Inokuchi M, Tanioka T, Nagakawa M, Okuno K, Gokita K, Kojima K. Laparoscopic distal gastrectomy is feasible in very elderly patients as compared with open distal gastrectomy. J Invest Surg. 2017;22:1–7. Inokuchi M, Tanioka T, Nagakawa M, Okuno K, Gokita K, Kojima K. Laparoscopic distal gastrectomy is feasible in very elderly patients as compared with open distal gastrectomy. J Invest Surg. 2017;22:1–7.
29.
go back to reference Kim SM, Youn HG, An JY, Choi YY, Noh SH, Oh SJ, et al. Comparison of open and laparoscopic gastrectomy in elderly patients. J Gastrointest Surg. 2018;22:785–91.CrossRef Kim SM, Youn HG, An JY, Choi YY, Noh SH, Oh SJ, et al. Comparison of open and laparoscopic gastrectomy in elderly patients. J Gastrointest Surg. 2018;22:785–91.CrossRef
30.
go back to reference Matsushita I, Hanai H, Kajimura M, Tamakoshi K, Nakajima T, Matsubayashi Y, et al. Should gastric cancer patients more than 80 years of age undergo surgery? Comparison with patients not treated surgically concerning prognosis and quality of life. J Clin Gastroenterol. 2002;35:29–34.CrossRef Matsushita I, Hanai H, Kajimura M, Tamakoshi K, Nakajima T, Matsubayashi Y, et al. Should gastric cancer patients more than 80 years of age undergo surgery? Comparison with patients not treated surgically concerning prognosis and quality of life. J Clin Gastroenterol. 2002;35:29–34.CrossRef
31.
go back to reference Choo JW, Ju Y, Lim H, Youn SH, Soh JS, Park JW, et al. Is it beneficial to perform surgical resection in elderly patients more than 80 years old with advanced gastric cancer. Scand J Gastroenterol. 2017;52:1057–64.CrossRef Choo JW, Ju Y, Lim H, Youn SH, Soh JS, Park JW, et al. Is it beneficial to perform surgical resection in elderly patients more than 80 years old with advanced gastric cancer. Scand J Gastroenterol. 2017;52:1057–64.CrossRef
32.
go back to reference Okabe H, Obama K, Tsunoda S, Tanaka E, Sakai Y. Advantage of completely laparoscopic gastrectomy with linear stapled reconstruction. A long-term follow-up study. Ann Surg. 2014;259:109–16.CrossRef Okabe H, Obama K, Tsunoda S, Tanaka E, Sakai Y. Advantage of completely laparoscopic gastrectomy with linear stapled reconstruction. A long-term follow-up study. Ann Surg. 2014;259:109–16.CrossRef
33.
go back to reference Zhuang CL, Huang DD, Pang WY, Zhou CJ, Wang SL, Lou N, et al. Sarcopenia is an independent predictor of severe postoperative complications and long-term survival after radical gastrectomy for gastric cancer: analysis from a large-scale cohort. Medicine. 2016;95:e3164.CrossRef Zhuang CL, Huang DD, Pang WY, Zhou CJ, Wang SL, Lou N, et al. Sarcopenia is an independent predictor of severe postoperative complications and long-term survival after radical gastrectomy for gastric cancer: analysis from a large-scale cohort. Medicine. 2016;95:e3164.CrossRef
34.
go back to reference Nishigori T, Tsunoda S, Obama K, Hisamori K, Hashimoto K, Itatani Y, et al. Optimal cutoff values of skeletal muscle index to define sarcopenia for prediction of survival in patients with advanced gastric cancer. Ann Surg Oncol. 2018;25:3596–603.CrossRef Nishigori T, Tsunoda S, Obama K, Hisamori K, Hashimoto K, Itatani Y, et al. Optimal cutoff values of skeletal muscle index to define sarcopenia for prediction of survival in patients with advanced gastric cancer. Ann Surg Oncol. 2018;25:3596–603.CrossRef
35.
go back to reference Liu P, Hao Q, Hai S, Wang H, Cao Li, Dong B. Sarcopenia as a predictor of all-cause mortality among community-dwelling older people: a systematic review and meta-analysis. Maturitas. 2017;103:16–22.CrossRef Liu P, Hao Q, Hai S, Wang H, Cao Li, Dong B. Sarcopenia as a predictor of all-cause mortality among community-dwelling older people: a systematic review and meta-analysis. Maturitas. 2017;103:16–22.CrossRef
36.
go back to reference Beaudart C, Zaaria M, Pasleau F, Reginster JY, Bruyere O. Health outcomes of sarcopenia: a systematic review and meta-analysis. PLoS ONE. 2017;12:e0169548.CrossRef Beaudart C, Zaaria M, Pasleau F, Reginster JY, Bruyere O. Health outcomes of sarcopenia: a systematic review and meta-analysis. PLoS ONE. 2017;12:e0169548.CrossRef
Metadata
Title
The safety and feasibility of laparoscopic gastrectomy for gastric cancer in very elderly patients: short-and long-term outcomes
Authors
Ryuichi Mikami
Eiji Tanaka
Teppei Murakami
Satoshi Ishida
Yugo Matsui
Kenta Horita
Masaki Yamada
Takashi Nitta
Masahiro Mise
Takehisa Harada
Masahiko Takeo
Shigeki Arii
Publication date
01-02-2021
Publisher
Springer Singapore
Published in
Surgery Today / Issue 2/2021
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-02078-4

Other articles of this Issue 2/2021

Surgery Today 2/2021 Go to the issue