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Surgery Today
Published in: Surgery Today 7/2020

01-07-2020 | Enterostomy | Original Article

Early renal dysfunction after temporary ileostomy construction

Authors: Mizunori Yaegashi, Koki Otsuka, Toshimoto Kimura, Teppei Matsuo, Hitoshi Fujii, Kei Sato, Kiyoharu Takashimizu, Tomoki Hatanaka, Toru Yoshida, Chihiro Tono, Akira Sasaki

Published in: Surgery Today | Issue 7/2020

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Abstract

Purpose

Loop ileostomy is often used to prevent complications after colorectal surgery, but it has been reported to cause renal impairment. This study aimed to evaluate the changes in the renal function after ileostomy and to compare these with the renal function after low anterior resection without ileostomy (low-ANT).

Methods

The subjects included 58 patients who underwent ileostomy construction and closure for rectal cancer. The estimated glomerular filtration rate (eGFR) was calculated at specific time points after the index surgery. In addition, we conducted a case-matched study on 147 patients who underwent low-ANT.

Results

The eGFR was significantly lower at 1 month after ileostomy than at the time of ileostomy construction (78.8 vs. 84.0, p < 0.0001) and did not improve after ileostomy closure. The only risk factor for a reduced eGFR was preoperative chemotherapy or chemoradiotherapy. In the case-matched study, 36 patients were allocated for each of the two groups. The number of ileostomy patients with a reduced eGFR was significantly increased 1 month after the index surgery (p = 0.005).

Conclusions

The eGFR began to decrease at one month after ileostomy construction and did not improve after ileostomy closure.
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Metadata
Title
Early renal dysfunction after temporary ileostomy construction
Authors
Mizunori Yaegashi
Koki Otsuka
Toshimoto Kimura
Teppei Matsuo
Hitoshi Fujii
Kei Sato
Kiyoharu Takashimizu
Tomoki Hatanaka
Toru Yoshida
Chihiro Tono
Akira Sasaki
Publication date
01-07-2020
Publisher
Springer Singapore
Published in
Surgery Today / Issue 7/2020
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-019-01938-y

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