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Surgery Today
Published in: Surgery Today 4/2018

01-04-2018 | Original Article

Combined analysis of the preoperative and postoperative prognostic nutritional index offers a precise predictor of the prognosis of patients with gastric cancer

Authors: Yuki Murakami, Hiroaki Saito, Yusuke Kono, Yuji Shishido, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara

Published in: Surgery Today | Issue 4/2018

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Abstract

Purpose

The prognostic nutritional index (PNI) is considered useful for predicting the prognosis of patients with gastric cancer (GC). This retrospective study investigated the relationship between both the pre- and postoperative PNI and the prognosis of GC patients.

Methods

The subjects of this study were 254 patients who underwent curative surgery for histopathologically diagnosed GC.

Results

Patients were divided according to their pre- and postoperative PNI as follows: preoperative PNI of ≥ 52 (pre-PNIHigh), preoperative PNI of < 52 (pre-PNILow), postoperative PNI of ≥ 49 (post-PNIHigh), and postoperative PNI of < 49 (pre-PNILow). Both pre- and postoperative PNI were significantly associated with GC prognosis. Patients were then divided as follows: group A, patients with pre-PNIHigh and post-PNIHigh; group B, patients with either pre-PNIHigh and post-PNILow or pre-PNILow and post-PNIHigh; and group C, patients with pre-PNILow and post-PNILow. The 5-year survival rates were 100.0, 83.0, and 67.1% for groups A, B, and C, respectively. Multivariate analysis indicated that the combination of pre- and postoperative PNI was an independent prognostic indicator.

Conclusions

Combined analysis of the pre- and postoperative PNI offers accurate information about the prognosis of patients with GC.
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Metadata
Title
Combined analysis of the preoperative and postoperative prognostic nutritional index offers a precise predictor of the prognosis of patients with gastric cancer
Authors
Yuki Murakami
Hiroaki Saito
Yusuke Kono
Yuji Shishido
Hirohiko Kuroda
Tomoyuki Matsunaga
Yoji Fukumoto
Tomohiro Osaki
Keigo Ashida
Yoshiyuki Fujiwara
Publication date
01-04-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 4/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1599-2

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